Leading articles

	Some of the challenges in drug development for irritable bowel syndrome E A MAYER Gut 2001; 48: 585-586. doi:10.1136/gut.48.5.585 [Extract] [Full text] [PDF] [Request Permissions]
	Dietary fibre and the risk of colorectal cancer R A GOODLAD Gut 2001; 48: 587-589. doi:10.1136/gut.48.5.587 [Extract] [Full text] [PDF] [Request Permissions]

Commentaries

	Helicobacter pylori, harmful to the brain? A T BLEI Gut 2001; 48: 590-591. doi:10.1136/gut.48.5.590 [Extract] [Full text] [PDF] [Request Permissions]
	Rational dosing of azathioprine and 6-mercaptopurine W J SANDBORN Gut 2001; 48: 591-592. doi:10.1136/gut.48.5.591 [Extract] [Full text] [PDF] [Request Permissions]
	New pouches for old? N MORTENSEN Gut 2001; 48: 592-593. doi:10.1136/gut.48.5.592 [Extract] [Full text] [PDF] [Request Permissions]

Science alerts

	Landscaper seeks remunerative position R J PLAYFORD Gut 2001; 48: 594-595. doi:10.1136/gut.48.5.594 [Extract] [Full text] [PDF] [Request Permissions]

Clinical alerts

	Serotonin receptor modulation in irritable bowel syndrome: one step forwards and one step backwards P J WHORWELL Gut 2001; 48: 596-597. doi:10.1136/gut.48.5.596 [Extract] [Full text] [PDF] [Request Permissions]

Helicobacter pylori

	Helicobacter pylori infection induced alteration of gene expression in human gastric cells C-C Chiou, C-C Chan, D-L Sheu, K-T Chen, Y-S Li, and E-C Chan Gut 2001; 48: 598-604. doi:10.1136/gut.48.5.598 [Abstract] [Full text] [PDF] [Request Permissions]
	Helicobacter pylori infection induces hyperammonaemia in Mongolian gerbils with liver cirrhosis H Suto, T Azuma, S Ito, M Ohtani, M Dojo, Y Ito, Y Kohli, and M Kuriyama Gut 2001; 48: 605-608. doi:10.1136/gut.48.5.605 [Abstract] [Full text] [PDF] [Request Permissions]

Therapy update

	Probiotics in inflamatory bowel disease F Shanahan Gut 2001; 48: 609. doi:10.1136/gut.48.5.609 [Extract] [Full text] [PDF] [Request Permissions]
	Antibiotics in Crohn's disease J-F Colombel, A Cortot, and H J van Kruiningen Gut 2001; 48: 647. doi:10.1136/gut.48.5.647 [Extract] [Full text] [PDF] [Request Permissions]

Inflammation and inflammatory bowel disease

	Absence of endogenous interleukin 10 enhances early stress response during post-ischaemic injury in mice intestine B Zingarelli, Z Yang, P W Hake, A Denenberg, and H R Wong Gut 2001; 48: 610-622. doi:10.1136/gut.48.5.610 [Abstract] [Full text] [PDF] [Request Permissions]
	Upregulation of Reg 1 and GW112 in the epithelium of inflamed colonic mucosa S Shinozaki, T Nakamura, M Iimura, Y Kato, B Iizuka, M Kobayashi, and N Hayashi Gut 2001; 48: 623-629. doi:10.1136/gut.48.5.623 [Abstract] [Full text] [PDF] [Request Permissions]
	Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat J Santos, P-C Yang, J D Söderholm, M Benjamin, and M H Perdue Gut 2001; 48: 630-636. doi:10.1136/gut.48.5.630 [Abstract] [Full text] [PDF] [Request Permissions]
	No evidence of persistent mumps virus infection in inflammatory bowel disease M Iizuka, H Saito, M Yukawa, H Itou, T Shirasaka, M Chiba, T Fukushima, and S Watanabe Gut 2001; 48: 637-641. doi:10.1136/gut.48.5.637 [Abstract] [Full text] [PDF] [Request Permissions]
	Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease C Cuffari, S Hunt, and T Bayless Gut 2001; 48: 642-646. doi:10.1136/gut.48.5.642 [Abstract] [Full text] [PDF] [Request Permissions]

Proliferation and cancer

	Dramatic diurnal variation in the concentration of the human trefoil peptide TFF2 in gastric juice J I Semple, J L Newton, B R Westley, and F E B May Gut 2001; 48: 648-655. doi:10.1136/gut.48.5.648 [Abstract] [Full text] [PDF] [Request Permissions]
	Genetic alterations and growth pattern in biliary duct carcinomas: loss of heterozygosity at chromosome 5q bears a close relation with polypoid growth E Hidaka, A Yanagisawa, M Seki, T Setoguchi, and Y Kato Gut 2001; 48: 656-659. doi:10.1136/gut.48.5.656 [Abstract] [Full text] [PDF] [Request Permissions]
	Non-steroidal anti-inflammatory drugs with activity against either cyclooxygenase 1 or cyclooxygenase 2 inhibit colorectal cancer in a DMH rodent model by inducing apoptosis and inhibiting cell proliferation W A Brown, S A Skinner, C Malcontenti-Wilson, D Vogiagis, and P E O'Brien Gut 2001; 48: 660-666. doi:10.1136/gut.48.5.660 [Abstract] [Full text] [PDF] [Request Permissions]
	Circumferential resection margin involvement: an independent predictor of survival following surgery for oesophageal cancer S P L Dexter, H Sue-Ling, M J McMahon, P Quirke, N Mapstone, and I G Martin Gut 2001; 48: 667-670. doi:10.1136/gut.48.5.667 [Abstract] [Full text] [PDF] [Request Permissions]

Motility and visceral sensation

	Analysis of the RET, GDNF, EDN3, and EDNRB genes in patients with intestinal neuronal dysplasia and Hirschsprung disease R Gath, A Goessling, K-M Keller, S Koletzko, W Coerdt, H Müntefering, S Wirth, R M W Hofstra, L Mulligan, C Eng, and A von Deimling Gut 2001; 48: 671-675. doi:10.1136/gut.48.5.671 [Abstract] [Full text] [PDF] [Request Permissions]
	Effects of octreotide on responses to colorectal distension in the rat X Su, M B Burton, and G F Gebhart Gut 2001; 48: 676-682. doi:10.1136/gut.48.5.676 [Abstract] [Full text] [PDF] [Request Permissions]
	Functional results and visceral perception after ileo neo-rectal anastomosis in patients: a pilot study G I Andriesse, H G Gooszen, M E I Schipper, L M A Akkermans, T J M V van Vroonhoven, and C J H M van Laarhoven Gut 2001; 48: 683-689. doi:10.1136/gut.48.5.683 [Abstract] [Full text] [PDF] [Request Permissions]
	Modification of small bowel mechanosensitivity by intestinal fat A M Accarino, F Azpiroz, and J-R Malagelada Gut 2001; 48: 690-695. doi:10.1136/gut.48.5.690 [Abstract] [Full text] [PDF] [Request Permissions]

Coeliac disease

	Candidate gene regions and genetic heterogeneity in gluten sensitivity P Holopainen, K Mustalahti, P Uimari, P Collin, M Mäki, and J Partanen Gut 2001; 48: 696-701. doi:10.1136/gut.48.5.696 [Abstract] [Full text] [PDF] [Request Permissions]

Gallstones

	Biliary lipid composition in cholesterol microlithiasis M Fracchia, S Pellegrino, P Secreto, L Gallo, G Masoero, A Pera, and G Galatola Gut 2001; 48: 702-706. doi:10.1136/gut.48.5.702 [Abstract] [Full text] [PDF] [Request Permissions]

Liver disease

	The epidemiology of hepatitis C in a UK health regional population of 5.12 million A H Mohsen and Trent HCV Study Group Gut 2001; 48: 707-713. doi:10.1136/gut.48.5.707 [Abstract] [Full text] [PDF] [Request Permissions]
	Low frequency of HLA-DRB1*11 in hepatitis C virus induced end stage liver disease H L Tillmann, D-F Chen, C Trautwein, V Kliem, A Grundey, A Berning-Haag, K Böker, S Kubicka, L Pastucha, W Stangel, and M P Manns Gut 2001; 48: 714-718. doi:10.1136/gut.48.5.714 [Abstract] [Full text] [PDF] [Request Permissions]

Case reports

	Heterotopic gastric mucosa together with intestinal metaplasia and moderate dysplasia in the gall bladder: report of two clinically unusual cases with literature review N Xeropotamos, A S Skopelitou, Ch Batsis, and A M Kappas Gut 2001; 48: 719-723. doi:10.1136/gut.48.5.719 [Abstract] [Full text] [PDF] [Request Permissions]
	Distinct outcomes of chloride diarrhoea in two siblings with identical genetic background of the disease: implications for early diagnosis and treatment P Höglund, C Holmberg, P Sherman, and J Kere Gut 2001; 48: 724-727. doi:10.1136/gut.48.5.724 [Abstract] [Full text] [PDF] [Request Permissions]
	A winking anus may signify spinal injury A J MALOUF and M A KAMM Gut 2001; 48: 728-729. doi:10.1136/gut.48.5.728 [Extract] [Full text] [PDF] [Request Permissions]

Occasional viewpoint

	Persistent low prevalence of Western digestive diseases in Africa: confounding aetiological factors I SEGAL, A R P WALKER, and A WADEE Gut 2001; 48: 730-732. doi:10.1136/gut.48.5.730 [Extract] [Full text] [PDF] [Request Permissions]

Reviews

	The promise and potential hazards of adenovirus gene therapy L S YOUNG and V MAUTNER Gut 2001; 48: 733-736. doi:10.1136/gut.48.5.733 [Extract] [Full text] [PDF] [Request Permissions]

Letters to the editor

	Grading system for inflammation in ulcerative colitis • Reply S S CROSS, K GEBOES, R RIDDELL, A ÖST, B JENSFELT, T PERSSON, and R LÖFBERG Gut 2001; 48: 737. doi:10.1136/gut.48.5.737 [Extract] [Full text] [PDF] [Request Permissions]
	Insulin and gall stones K W HEATON, P M EMMETT, G MISCIAGNA, and M TREVISAN Gut 2001; 48: 737-738. doi:10.1136/gut.48.5.737a [Extract] [Full text] [PDF] [Request Permissions]
	Heparin as an anti-inflammatory agent: it's no GAG to forget about chemokines S J CONNOR and M C GRIMM Gut 2001; 48: 738. doi:10.1136/gut.48.5.738 [Extract] [Full text] [PDF] [Request Permissions]
	Management of variceal haemorrhage in cirrhotic patients • Reply A K BURROUGHS, D W PATCH, R JALAN, and P C HAYES Gut 2001; 48: 738-740. doi:10.1136/gut.48.5.738a [Extract] [Full text] [PDF] [Request Permissions]
	Long term follow up of interferon responder children with chronic hepatitis B N KOÇAK, I N SALTIK, H ÖZEN, F GÜRAKAN, and A YÜCE Gut 2001; 48: 740. doi:10.1136/gut.48.5.740 [Extract] [Full text] [PDF] [Request Permissions]
	Renal sodium handling in preascitic cirrhosis G SANSOÈ, A FERRARI, J CLÀRIA, and J RODÉS Gut 2001; 48: 740-741. doi:10.1136/gut.48.5.740a [Extract] [Full text] [PDF] [Request Permissions]

Book reviews

	Comprehensive Clinical Hepatology. D H ADAMS Gut 2001; 48: 741. doi:10.1136/gut.48.5.741 [Extract] [Full text] [PDF] [Request Permissions]
	Atlas of Gastroenterology S CAIRNS Gut 2001; 48: 741. doi:10.1136/gut.48.5.741a [Extract] [Full text] [PDF] [Request Permissions]
	Endoscopic Gastric Surgery. R C MASON Gut 2001; 48: 741. doi:10.1136/gut.48.5.741b [Extract] [Full text] [PDF] [Request Permissions]

Corrections

	Correction for vol. 48, p. 68 Gut 2001; 48: 741. [Extract] [Full text] [PDF] [Request Permissions]