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December 2001 (Volume 49, Number 6). [Index by author]

	(Cover illustration)	Leading articles Commentaries Clinical alerts Science alerts Debate Gastro-oesophageal reflux Inflammation and inflammatory bowel disease Immunology Motility and visceral sensation Cancer Pancreatitis Liver disease Case reports Gut file Reviews Letters to the editor Book reviews

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Leading articles

The putative role of inflammation in the irritable bowel syndrome
S M COLLINS, T PICHE, and P RAMPAL
Gut 2001; 49: 743-745. doi:10.1136/gut.49.6.743 [Extract] [Full text] [PDF] [Request Permissions]

Commentaries

The continuing tale of cytokeratins in Barrett's mucosa: As you like it
A LATCHFORD, B EKSTEEN, and J JANKOWSKI
Gut 2001; 49: 746-747. doi:10.1136/gut.49.6.746 [Extract] [Full text] [PDF] [Request Permissions]

Monocytes or T cells in Crohn's disease: does IL-16 allow both to play at that game?
S SCHREIBER
Gut 2001; 49: 747-748. doi:10.1136/gut.49.6.747 [Extract] [Full text] [PDF] [Request Permissions]

Sodium in preascitic cirrhosis: please pass the salt
J CLÀRIA and J RODÉS
Gut 2001; 49: 748-749. doi:10.1136/gut.49.6.748 [Extract] [Full text] [PDF] [Request Permissions]

Clinical alerts

Heavy drinking greatly increases the risk of cirrhosis in patients with HCV hepatitis
C P DAY
Gut 2001; 49: 750-751. doi:10.1136/gut.49.6.750 [Extract] [Full text] [PDF] [Request Permissions]

Science alerts

NOD2 (CARD15), the first susceptibility gene for Crohn's disease
D P B McGOVERN, D A VAN HEEL, T AHMAD, and D P JEWELL
Gut 2001; 49: 752-754. doi:10.1136/gut.49.6.752 [Extract] [Full text] [PDF] [Request Permissions]

Debate

PROTAGONIST: Mycobacterium avium subspecies paratuberculosis is a cause of Crohn's disease
J Hermon-Taylor
Gut 2001; 49: 755-757. doi:10.1136/gut.49.6.755 [Extract] [Full text] [PDF] [Request Permissions]

ANTAGONIST: Mycobacterium avium subspecies paratuberculosis is a cause of Crohn's disease
P Quirke
Gut 2001; 49: 757-760. doi:10.1136/gut.49.6.757 [Extract] [Full text] [PDF] [Request Permissions]

Gastro-oesophageal reflux

Cytokeratin immunoreactivity of intestinal metaplasia at normal oesophagogastric junction indicates its aetiology
A Couvelard, J-M Cauvin, D Goldfain, A Rotenberg, M Robaszkiewicz, and J-F Fléjou
Gut 2001; 49: 761-766. doi:10.1136/gut.49.6.761 [Abstract] [Full text] [PDF] [Request Permissions]

Temporal associations between coughing or wheezing and acid reflux in asthmatics
B Avidan, A Sonnenberg, T G Schnell, and S J Sontag
Gut 2001; 49: 767-772. doi:10.1136/gut.49.6.767 [Abstract] [Full text] [PDF] [Request Permissions]

Inflammation and inflammatory bowel disease

Diagnostic misclassification reduces the ability to detect linkage in inflammatory bowel disease genetic studies
M S Silverberg, M J Daly, D N Moskovitz, J D Rioux, R S McLeod, Z Cohen, G R Greenberg, T J Hudson, K A Siminovitch, and A H Steinhart
Gut 2001; 49: 773-776. doi:10.1136/gut.49.6.773 [Abstract] [Full text] [PDF] [Request Permissions]

Behaviour of Crohn's disease according to the Vienna classification: changing pattern over the course of the disease
E Louis, A Collard, A F Oger, E Degroote, F Aboul Nasr El Yafi, and J Belaiche
Gut 2001; 49: 777-782. doi:10.1136/gut.49.6.777 [Abstract] [Full text] [PDF] [Request Permissions]

Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses
W Kruis, S Schreiber, D Theuer, J-W Brandes, E Schütz, S Howaldt, B Krakamp, J Hämling, H Mönnikes, I Koop, M Stolte, D Pallant, and U Ewald
Gut 2001; 49: 783-789. doi:10.1136/gut.49.6.783 [Abstract] [Full text] [PDF] [Request Permissions]

A randomised controlled trial of high versus low long chain triglyceride whole protein feed in active Crohn's disease
K Leiper, J Woolner, M M C Mullan, T Parker, M van der Vliet, S Fear, J M Rhodes, and J O Hunter
Gut 2001; 49: 790-794. doi:10.1136/gut.49.6.790 [Abstract] [Full text] [PDF] [Request Permissions]

Interleukin 16 expression and phenotype of interleukin 16 producing cells in Crohn's disease
P Middel, K Reich, F Polzien, V Blaschke, B Hemmerlein, J Herms, M Korabiowska, and H-J Radzun
Gut 2001; 49: 795-803. doi:10.1136/gut.49.6.795 [Abstract] [Full text] [PDF] [Request Permissions]

Immunology

Frequency of clonal intraepithelial T lymphocyte proliferations in enteropathy-type intestinal T cell lymphoma, coeliac disease, and refractory sprue
S Daum, D Weiss, M Hummel, R Ullrich, W Heise, H Stein, E-O Riecken, H-D Foss, and Intestinal Lymphoma Study Group
Gut 2001; 49: 804-812. doi:10.1136/gut.49.6.804 [Abstract] [Full text] [PDF] [Request Permissions]

Motility and visceral sensation

Prolonged manometric recordings of oesophagus and lower oesophageal sphincter in achalasia patients
M A van Herwaarden, M Samsom, and A J P M Smout
Gut 2001; 49: 813-821. doi:10.1136/gut.49.6.813 [Abstract] [Full text] [PDF] [Request Permissions]

Intestinal inflammation and activation of sensory nerve pathways: a functional and morphological study in the nematode infected rat
R De Giorgio, G Barbara, P Blennerhassett, L Wang, V Stanghellini, R Corinaldesi, S M Collins, and G Tougas
Gut 2001; 49: 822-827. doi:10.1136/gut.49.6.822 [Abstract] [Full text] [PDF] [Request Permissions]

Effects of cisapride on gall bladder emptying, intestinal transit, and serum deoxycholate: a prospective, randomised, double blind, placebo controlled trial
M J Veysey, P Malcolm, A I Mallet, P J Jenkins, G M Besser, G M Murphy, and R H Dowling
Gut 2001; 49: 828-834. doi:10.1136/gut.49.6.828 [Abstract] [Full text] [PDF] [Request Permissions]

Cancer

Bile acid metabolism by fresh human colonic contents: a comparison of caecal versus faecal samples
L A Thomas, M J Veysey, G French, P B Hylemon, G M Murphy, and R H Dowling
Gut 2001; 49: 835-842. doi:10.1136/gut.49.6.835 [Abstract] [Full text] [PDF] [Request Permissions]

Pancreatitis

Effect of somatostatin on the sphincter of Oddi in patients with acute non-biliary pancreatitis
K-H Lai, G-H Lo, J-S Cheng, M-T Fu, E-M Wang, H-H Chan, Y-Y Wang, P-I Hsu, and C-K Lin
Gut 2001; 49: 843-846. doi:10.1136/gut.49.6.843 [Abstract] [Full text] [PDF] [Request Permissions]

Liver disease

Sodium homeostasis with chronic sodium loading in preascitic cirrhosis
F Wong, P Liu, and L Blendis
Gut 2001; 49: 847-851. doi:10.1136/gut.49.6.847 [Abstract] [Full text] [PDF] [Request Permissions]

Antiphospholipid antibodies associated with alcoholic liver disease specifically recognise oxidised phospholipids
R Rolla, D Vay, E Mottaran, M Parodi, M Vidali, M Sartori, C Rigamonti, G Bellomo, and E Albano
Gut 2001; 49: 852-859. doi:10.1136/gut.49.6.852 [Abstract] [Full text] [PDF] [Request Permissions]

Case reports

Acute liver graft failure due to emergence of lamivudine resistant hepatitis B virus: rapid resolution during treatment with adefovir
D Mutimer, B H Feraz-Neto, R Harrison, K O'Donnell, J Shaw, P Cane, and D Pillay
Gut 2001; 49: 860-863. doi:10.1136/gut.49.6.860 [Abstract] [Full text] [PDF] [Request Permissions]

Gut file

Dengue virus induced hepatitis with chronic calcific changes
A FABRE, A COUVELARD, C DEGOTT, C LAGORCE-PAGÈS, F BRUNEEL, E BOUVET, and F VACHON
Gut 2001; 49: 864-865. doi:10.1136/gut.49.6.864 [Extract] [Full text] [PDF] [Request Permissions]

Reviews

Portal hypertensive gastropathy and gastric antral vascular ectasia (GAVE) syndrome
K W BURAK, S S LEE, and P L BECK
Gut 2001; 49: 866-872. doi:10.1136/gut.49.6.866 [Extract] [Full text] [PDF] [Request Permissions]

Letters to the editor

Aminosalicylate as prophylaxis for Crohn's disease
A QASIM, J SEERY, and C A O'MORAIN
Gut 2001; 49: 873. doi:10.1136/gut.49.6.873 [Extract] [Full text] [PDF] [Request Permissions]

Probiotics in IBD
R J KENNEDY, S J KIRK, and K R GARDINER
Gut 2001; 49: 873. doi:10.1136/gut.49.6.873a [Extract] [Full text] [PDF] [Request Permissions]

Probiotics in Crohn's disease
M GUSLANDI
Gut 2001; 49: 873-874. doi:10.1136/gut.49.6.873b [Extract] [Full text] [PDF] [Request Permissions]

Survey of informed consent for endoscopy
A I THURAISINGAM
Gut 2001; 49: 874. doi:10.1136/gut.49.6.874 [Extract] [Full text] [PDF] [Request Permissions]

Why measure thiopurine methyltransferase activity? Direct administration of 6-thioguanine might be the alternative for 6-mercaptopurine or azathioprine
D de JONG, C J J MULDER, and A A van SORGE
Gut 2001; 49: 874-875. doi:10.1136/gut.49.6.874a [Extract] [Full text] [PDF] [Request Permissions]

Book reviews

Liver Biopsy Evaluation. Histological Diagnosis and Clinical Correlations
S HUBSCHER
Gut 2001; 49: 875. doi:10.1136/gut.49.6.875 [Extract] [Full text] [PDF] [Request Permissions]

Review on Upper Digestive Surgery $---$ Oesophagus, Stomach and Small Intestine
R C MASON
Gut 2001; 49: 875. doi:10.1136/gut.49.6.875a [Extract] [Full text] [PDF] [Request Permissions]

Cover

Endoscopic findings of portal hypertensive gastropathy with mosaic pattern and cherry red spots. (From the review by Buraket al, pp 866-872.)

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	The putative role of inflammation in the irritable bowel syndrome S M COLLINS, T PICHE, and P RAMPAL Gut 2001; 49: 743-745. doi:10.1136/gut.49.6.743 [Extract] [Full text] [PDF] [Request Permissions]

	The continuing tale of cytokeratins in Barrett's mucosa: As you like it A LATCHFORD, B EKSTEEN, and J JANKOWSKI Gut 2001; 49: 746-747. doi:10.1136/gut.49.6.746 [Extract] [Full text] [PDF] [Request Permissions]

	Monocytes or T cells in Crohn's disease: does IL-16 allow both to play at that game? S SCHREIBER Gut 2001; 49: 747-748. doi:10.1136/gut.49.6.747 [Extract] [Full text] [PDF] [Request Permissions]

	Sodium in preascitic cirrhosis: please pass the salt J CLÀRIA and J RODÉS Gut 2001; 49: 748-749. doi:10.1136/gut.49.6.748 [Extract] [Full text] [PDF] [Request Permissions]

	Heavy drinking greatly increases the risk of cirrhosis in patients with HCV hepatitis C P DAY Gut 2001; 49: 750-751. doi:10.1136/gut.49.6.750 [Extract] [Full text] [PDF] [Request Permissions]

	NOD2 (CARD15), the first susceptibility gene for Crohn's disease D P B McGOVERN, D A VAN HEEL, T AHMAD, and D P JEWELL Gut 2001; 49: 752-754. doi:10.1136/gut.49.6.752 [Extract] [Full text] [PDF] [Request Permissions]

	*PROTAGONIST: Mycobacterium avium* subspecies paratuberculosis is a cause of Crohn's disease** J Hermon-Taylor Gut 2001; 49: 755-757. doi:10.1136/gut.49.6.755 [Extract] [Full text] [PDF] [Request Permissions]

	*ANTAGONIST: Mycobacterium avium* subspecies paratuberculosis is a cause of Crohn's disease** P Quirke Gut 2001; 49: 757-760. doi:10.1136/gut.49.6.757 [Extract] [Full text] [PDF] [Request Permissions]

	Cytokeratin immunoreactivity of intestinal metaplasia at normal oesophagogastric junction indicates its aetiology A Couvelard, J-M Cauvin, D Goldfain, A Rotenberg, M Robaszkiewicz, and J-F Fléjou Gut 2001; 49: 761-766. doi:10.1136/gut.49.6.761 [Abstract] [Full text] [PDF] [Request Permissions]

	Temporal associations between coughing or wheezing and acid reflux in asthmatics B Avidan, A Sonnenberg, T G Schnell, and S J Sontag Gut 2001; 49: 767-772. doi:10.1136/gut.49.6.767 [Abstract] [Full text] [PDF] [Request Permissions]

	Diagnostic misclassification reduces the ability to detect linkage in inflammatory bowel disease genetic studies M S Silverberg, M J Daly, D N Moskovitz, J D Rioux, R S McLeod, Z Cohen, G R Greenberg, T J Hudson, K A Siminovitch, and A H Steinhart Gut 2001; 49: 773-776. doi:10.1136/gut.49.6.773 [Abstract] [Full text] [PDF] [Request Permissions]

	Behaviour of Crohn's disease according to the Vienna classification: changing pattern over the course of the disease E Louis, A Collard, A F Oger, E Degroote, F Aboul Nasr El Yafi, and J Belaiche Gut 2001; 49: 777-782. doi:10.1136/gut.49.6.777 [Abstract] [Full text] [PDF] [Request Permissions]

	Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses W Kruis, S Schreiber, D Theuer, J-W Brandes, E Schütz, S Howaldt, B Krakamp, J Hämling, H Mönnikes, I Koop, M Stolte, D Pallant, and U Ewald Gut 2001; 49: 783-789. doi:10.1136/gut.49.6.783 [Abstract] [Full text] [PDF] [Request Permissions]

	A randomised controlled trial of high versus low long chain triglyceride whole protein feed in active Crohn's disease K Leiper, J Woolner, M M C Mullan, T Parker, M van der Vliet, S Fear, J M Rhodes, and J O Hunter Gut 2001; 49: 790-794. doi:10.1136/gut.49.6.790 [Abstract] [Full text] [PDF] [Request Permissions]

	Interleukin 16 expression and phenotype of interleukin 16 producing cells in Crohn's disease P Middel, K Reich, F Polzien, V Blaschke, B Hemmerlein, J Herms, M Korabiowska, and H-J Radzun Gut 2001; 49: 795-803. doi:10.1136/gut.49.6.795 [Abstract] [Full text] [PDF] [Request Permissions]

	Frequency of clonal intraepithelial T lymphocyte proliferations in enteropathy-type intestinal T cell lymphoma, coeliac disease, and refractory sprue S Daum, D Weiss, M Hummel, R Ullrich, W Heise, H Stein, E-O Riecken, H-D Foss, and Intestinal Lymphoma Study Group Gut 2001; 49: 804-812. doi:10.1136/gut.49.6.804 [Abstract] [Full text] [PDF] [Request Permissions]

	Prolonged manometric recordings of oesophagus and lower oesophageal sphincter in achalasia patients M A van Herwaarden, M Samsom, and A J P M Smout Gut 2001; 49: 813-821. doi:10.1136/gut.49.6.813 [Abstract] [Full text] [PDF] [Request Permissions]

	Intestinal inflammation and activation of sensory nerve pathways: a functional and morphological study in the nematode infected rat R De Giorgio, G Barbara, P Blennerhassett, L Wang, V Stanghellini, R Corinaldesi, S M Collins, and G Tougas Gut 2001; 49: 822-827. doi:10.1136/gut.49.6.822 [Abstract] [Full text] [PDF] [Request Permissions]

	Effects of cisapride on gall bladder emptying, intestinal transit, and serum deoxycholate: a prospective, randomised, double blind, placebo controlled trial M J Veysey, P Malcolm, A I Mallet, P J Jenkins, G M Besser, G M Murphy, and R H Dowling Gut 2001; 49: 828-834. doi:10.1136/gut.49.6.828 [Abstract] [Full text] [PDF] [Request Permissions]

	Bile acid metabolism by fresh human colonic contents: a comparison of caecal versus faecal samples L A Thomas, M J Veysey, G French, P B Hylemon, G M Murphy, and R H Dowling Gut 2001; 49: 835-842. doi:10.1136/gut.49.6.835 [Abstract] [Full text] [PDF] [Request Permissions]

	Effect of somatostatin on the sphincter of Oddi in patients with acute non-biliary pancreatitis K-H Lai, G-H Lo, J-S Cheng, M-T Fu, E-M Wang, H-H Chan, Y-Y Wang, P-I Hsu, and C-K Lin Gut 2001; 49: 843-846. doi:10.1136/gut.49.6.843 [Abstract] [Full text] [PDF] [Request Permissions]

	Sodium homeostasis with chronic sodium loading in preascitic cirrhosis F Wong, P Liu, and L Blendis Gut 2001; 49: 847-851. doi:10.1136/gut.49.6.847 [Abstract] [Full text] [PDF] [Request Permissions]

	Antiphospholipid antibodies associated with alcoholic liver disease specifically recognise oxidised phospholipids R Rolla, D Vay, E Mottaran, M Parodi, M Vidali, M Sartori, C Rigamonti, G Bellomo, and E Albano Gut 2001; 49: 852-859. doi:10.1136/gut.49.6.852 [Abstract] [Full text] [PDF] [Request Permissions]

	Acute liver graft failure due to emergence of lamivudine resistant hepatitis B virus: rapid resolution during treatment with adefovir D Mutimer, B H Feraz-Neto, R Harrison, K O'Donnell, J Shaw, P Cane, and D Pillay Gut 2001; 49: 860-863. doi:10.1136/gut.49.6.860 [Abstract] [Full text] [PDF] [Request Permissions]

	Dengue virus induced hepatitis with chronic calcific changes A FABRE, A COUVELARD, C DEGOTT, C LAGORCE-PAGÈS, F BRUNEEL, E BOUVET, and F VACHON Gut 2001; 49: 864-865. doi:10.1136/gut.49.6.864 [Extract] [Full text] [PDF] [Request Permissions]

	Portal hypertensive gastropathy and gastric antral vascular ectasia (GAVE) syndrome K W BURAK, S S LEE, and P L BECK Gut 2001; 49: 866-872. doi:10.1136/gut.49.6.866 [Extract] [Full text] [PDF] [Request Permissions]

	Aminosalicylate as prophylaxis for Crohn's disease A QASIM, J SEERY, and C A O'MORAIN Gut 2001; 49: 873. doi:10.1136/gut.49.6.873 [Extract] [Full text] [PDF] [Request Permissions]

	Probiotics in IBD R J KENNEDY, S J KIRK, and K R GARDINER Gut 2001; 49: 873. doi:10.1136/gut.49.6.873a [Extract] [Full text] [PDF] [Request Permissions]

	Probiotics in Crohn's disease M GUSLANDI Gut 2001; 49: 873-874. doi:10.1136/gut.49.6.873b [Extract] [Full text] [PDF] [Request Permissions]

	Survey of informed consent for endoscopy A I THURAISINGAM Gut 2001; 49: 874. doi:10.1136/gut.49.6.874 [Extract] [Full text] [PDF] [Request Permissions]

	Why measure thiopurine methyltransferase activity? Direct administration of 6-thioguanine might be the alternative for 6-mercaptopurine or azathioprine D de JONG, C J J MULDER, and A A van SORGE Gut 2001; 49: 874-875. doi:10.1136/gut.49.6.874a [Extract] [Full text] [PDF] [Request Permissions]

	Liver Biopsy Evaluation. Histological Diagnosis and Clinical Correlations S HUBSCHER Gut 2001; 49: 875. doi:10.1136/gut.49.6.875 [Extract] [Full text] [PDF] [Request Permissions]

	Review on Upper Digestive Surgery $---$ Oesophagus, Stomach and Small Intestine R C MASON Gut 2001; 49: 875. doi:10.1136/gut.49.6.875a [Extract] [Full text] [PDF] [Request Permissions]