Leading articles

	Combination therapy for hepatitis B A M Di Bisceglie Gut 2002; 50: 443-445. doi:10.1136/gut.50.4.443 [Abstract] [Full text] [PDF] [Request Permissions]

Digest

	Digest Ian Forgacs Gut 2002; 50: 443. doi:10.1136/gut.50.4.443-a [Extract] [Full text] [PDF] [Request Permissions]

Commentaries

	Uncoupling the p38 MAPK kinase in IBD: a double edged sword? V Arulampalam and S Pettersson Gut 2002; 50: 446-447. doi:10.1136/gut.50.4.446 [Extract] [Full text] [PDF] [Request Permissions]
	Homeobox genes: going for growth R J Playford Gut 2002; 50: 447-448. doi:10.1136/gut.50.4.447 [Extract] [Full text] [PDF] [Request Permissions]

Science @lert

	Adhesion between dendritic cells and epithelial cells maintains the gut barrier during bacterial sampling J E Collins Gut 2002; 50: 449-450. doi:10.1136/gut.50.4.449 [Extract] [Full text] [PDF] [Request Permissions]

Gastro-oesophageal reflux

	Diversity in the oesophageal phenotypic response to gastro-oesophageal reflux: immunological determinants R C Fitzgerald, B A Onwuegbusi, M Bajaj-Elliott, I T Saeed, W R Burnham, and M J G Farthing Gut 2002; 50: 451-459. doi:10.1136/gut.50.4.451 [Abstract] [Full text] [PDF] [Request Permissions]

Peptic ulcer

	Recent trends in admissions and mortality due to peptic ulcer in England: increasing frequency of haemorrhage among older subjects J Higham, J-Y Kang, and A Majeed Gut 2002; 50: 460-464. doi:10.1136/gut.50.4.460 [Abstract] [Full text] [PDF] [Request Permissions]

Endoscopy

	Diagnostic accuracy of forceps biopsy versus polypectomy for gastric polyps: a prospective multicentre study S M Muehldorfer, M Stolte, P Martus, E G Hahn, and C Ell Gut 2002; 50: 465-470. doi:10.1136/gut.50.4.465 [Abstract] [Full text] [PDF] [Request Permissions]

Motility and visceral sensation

	The menstrual cycle affects rectal sensitivity in patients with irritable bowel syndrome but not healthy volunteers L A Houghton, R Lea, N Jackson, and P J Whorwell Gut 2002; 50: 471-474. doi:10.1136/gut.50.4.471 [Abstract] [Full text] [PDF] [Request Permissions]
	Microprocessor controlled movement of solid colonic content using sequential neural electrical stimulation M A Amaris, P Z Rashev, M P Mintchev, and K L Bowes Gut 2002; 50: 475-479. doi:10.1136/gut.50.4.475 [Abstract] [Full text] [PDF] [Request Permissions]
	Prevalence of faecal incontinence in adults aged 40 years or more living in the community S Perry, C Shaw, C McGrother, R J Matthews, R P Assassa, H Dallosso, K Williams, K R Brittain, U Azam, M Clarke, C Jagger, C Mayne, and C M Castleden Gut 2002; 50: 480-484. doi:10.1136/gut.50.4.480 [Abstract] [Full text] [PDF] [Request Permissions]

Inflammation and inflammatory bowel disease

	The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review A G Fraser, T R Orchard, and D P Jewell Gut 2002; 50: 485-489. doi:10.1136/gut.50.4.485 [Abstract] [Full text] [PDF] [Request Permissions]
	Bowel ultrasound in assessment of Crohn's disease and detection of related small bowel strictures: a prospective comparative study versus x ray and intraoperative findings F Parente, G Maconi, S Bollani, A Anderloni, G Sampietro, M Cristaldi, N Franceschelli, R Bianco, A M Taschieri, and G Bianchi Porro Gut 2002; 50: 490-495. doi:10.1136/gut.50.4.490 [Abstract] [Full text] [PDF] [Request Permissions]
	The vascularity of internal fistulae in Crohn's disease: an in vivo power Doppler ultrasonography assessment G Maconi, G M Sampietro, A Russo, S Bollani, M Cristaldi, F Parente, F Dottorini, and G Bianchi Porro Gut 2002; 50: 496-500. doi:10.1136/gut.50.4.496 [Abstract] [Full text] [PDF] [Request Permissions]
	Human neutrophil lipocalin is a unique marker of neutrophil inflammation in ulcerative colitis and proctitis M Carlson, Y Raab, L Sevéus, S Xu, R Hällgren, and P Venge Gut 2002; 50: 501-506. doi:10.1136/gut.50.4.501 [Abstract] [Full text] [PDF] [Request Permissions]
	Dichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitis T ten Hove, B van den Blink, I Pronk, P Drillenburg, M P Peppelenbosch, and S J H van Deventer Gut 2002; 50: 507-512. doi:10.1136/gut.50.4.507 [Abstract] [Full text] [PDF] [Request Permissions]

Colon cancer

	Aberrant P-cadherin expression is an early event in hyperplastic and dysplastic transformation in the colon R G Hardy, C Tselepis, J Hoyland, Y Wallis, T P Pretlow, I Talbot, D S A Sanders, G Matthews, D Morton, and J A Z Jankowski Gut 2002; 50: 513-519. doi:10.1136/gut.50.4.513 [Abstract] [Full text] [PDF] [Request Permissions]
	A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability B Shannon, S Gnanasampanthan, J Beilby, and B Iacopetta Gut 2002; 50: 520-524. doi:10.1136/gut.50.4.520 [Abstract] [Full text] [PDF] [Request Permissions]
	Stimulation of the intestinal Cdx2 homeobox gene by butyrate in colon cancer cells C Domon-Dell, Q Wang, S Kim, M Kedinger, B M Evers, and J-N Freund Gut 2002; 50: 525-529. doi:10.1136/gut.50.4.525 [Abstract] [Full text] [PDF] [Request Permissions]
	Detection of epithelial tumour RNA in the plasma of colon cancer patients is associated with advanced stages and circulating tumour cells J M Silva, R Rodriguez, J M Garcia, C Muñoz, J Silva, G Dominguez, M Provencio, P España, and F Bonilla Gut 2002; 50: 530-534. doi:10.1136/gut.50.4.530 [Abstract] [Full text] [PDF] [Request Permissions]

Pancreatic disease

	Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis P Mews, P Phillips, R Fahmy, M Korsten, R Pirola, J Wilson, and M Apte Gut 2002; 50: 535-541. doi:10.1136/gut.50.4.535 [Abstract] [Full text] [PDF] [Request Permissions]
	Apoptosis and proliferation of acinar and islet cells in chronic pancreatitis: evidence for differential cell loss mediating preservation of islet function A C Bateman, S M Turner, K S A Thomas, P R McCrudden, D R Fine, P A Johnson, C D Johnson, and J P Iredale Gut 2002; 50: 542-548. doi:10.1136/gut.50.4.542 [Abstract] [Full text] [PDF] [Request Permissions]
	Photodynamic therapy for cancer of the pancreas S G Bown, A Z Rogowska, D E Whitelaw, W R Lees, L B Lovat, P Ripley, L Jones, P Wyld, A Gillams, and A W R Hatfield Gut 2002; 50: 549-557. doi:10.1136/gut.50.4.549 [Abstract] [Full text] [PDF] [Request Permissions]

Liver disease

	Attenuated acute liver injury in mice by naked hepatocyte growth factor gene transfer into skeletal muscle with electroporation F Xue, T Takahara, Y Yata, M Minemura, C Y Morioka, S Takahara, E Yamato, K Dono, and A Watanabe Gut 2002; 50: 558-562. doi:10.1136/gut.50.4.558 [Abstract] [Full text] [PDF] [Request Permissions]
	A ligand for peroxisome proliferator activated receptor inhibits cell growth and induces apoptosis in human liver cancer cells M Toyoda, H Takagi, N Horiguchi, S Kakizaki, K Sato, H Takayama, and M Mori Gut 2002; 50: 563-567. doi:10.1136/gut.50.4.563 [Abstract] [Full text] [PDF] [Request Permissions]

Occasional viewpoint

	Hospital admissions for peptic ulcer and indigestion in London and New York in the 19th and early 20th centuries J H Baron and A Sonnenberg Gut 2002; 50: 568-570. doi:10.1136/gut.50.4.568 [Abstract] [Full text] [Web only Table] [PDF] [Request Permissions]

Reviews

	Hepatic stellate cells: role in microcirculation and pathophysiology of portal hypertension H Reynaert, M G Thompson, T Thomas, and A Geerts Gut 2002; 50: 571-581. doi:10.1136/gut.50.4.571 [Abstract] [Full text] [PDF] [Request Permissions]

Letters

	Recurrent diarrhoea and weight loss associated with cessation of smoking in undiagnosed coeliac disease O Jolobe and S J O Veldhuyzen van Zanten Gut 2002; 50: 582. doi:10.1136/gut.50.4.582 [Extract] [Full text] [PDF] [Request Permissions]

Book reviews

	Interactive Continuing Education in Gastroenterology CD-ROM: J Rhodes, A Forbes, H Hsin Tsai, et al. London: BSG and Harcourt Health Communications, 2000, £135.00. ISBN 0 7234 3214 7 R Valori Gut 2002; 50: 582-583. doi:10.1136/gut.50.4.582-a [Extract] [Full text] [PDF] [Request Permissions]
	Intestinal Failure: Edited by J Nightingale. London: Greenwich Medical Media Ltd, 2001, £85.00. ISBN 1 90015 193 6 S Gabe Gut 2002; 50: 583. doi:10.1136/gut.50.4.583 [Extract] [Full text] [PDF] [Request Permissions]
	Irritable Bowel Syndrome: Psychosocial Assessment and Treatment: E B Blanchard. Washington, DC: American Psychological Association, 2001, £33.95, pp 336. ISBN 1 55798 730 0 T R Bell Gut 2002; 50: 583-584. doi:10.1136/gut.50.4.583-a [Extract] [Full text] [PDF] [Request Permissions]

Corrections

	Corrections Gut 2002; 50: 584. doi:10.1136/gut.50.4.584 [Extract] [Full text] [PDF] [Request Permissions]