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June 2002 (Volume 50, Number 6). [Index by author]

	(Cover illustration)	Leading articles Digest Commentaries Clinical @lert Rapid communication Oesophagus Helicobacter pylori Small intestine Intestinal infection Inflammation and inflammatory bowel disease Cancer Liver disease Gut file Occasional viewpoint Reviews Letters Corrections

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Leading articles

Primary biliary cirrhosis: seeking the silent partner of autoimmunity
I Sutton and J Neuberger
Gut 2002; 50: 743-746. doi:10.1136/gut.50.6.743 [Abstract] [Full text] [PDF] [Request Permissions]

Digest

Digest
Ian Forgacs
Gut 2002; 50: 743. doi:10.1136/gut.50.6.743-a [Extract] [Full text] [PDF] [Request Permissions]

Commentaries

Easy as 1, 2, 3? Histamine receptors and gastric acid
I L P Beales
Gut 2002; 50: 747-748. doi:10.1136/gut.50.6.747 [Extract] [Full text] [PDF] [Request Permissions]

UGT1A1 polymorphisms and colorectal cancer susceptibility
N T Brockton
Gut 2002; 50: 748-749. doi:10.1136/gut.50.6.748 [Extract] [Full text] [PDF] [Request Permissions]

HCC: What's the score
D Shouval
Gut 2002; 50: 749-750. doi:10.1136/gut.50.6.749 [Extract] [Full text] [PDF] [Request Permissions]

Clinical @lert

Does chemoradiotherapy after intended curative surgery increase survival of gastric cancer patients?
A Cuschieri
Gut 2002; 50: 751. doi:10.1136/gut.50.6.751 [Extract] [Full text] [PDF] [Request Permissions]

Rapid communication

Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon
M Brittan, T Hunt, R Jeffery, R Poulsom, S J Forbes, K Hodivala-Dilke, J Goldman, M R Alison, and N A Wright
Gut 2002; 50: 752-757. doi:10.1136/gut.50.6.752 [Abstract] [Full text] [PDF] [Request Permissions]

Oesophagus

Effect of sildenafil on oesophageal motor function in healthy subjects and patients with oesophageal motor disorders
A J Eherer, I Schwetz, H F Hammer, T Petnehazy, S J Scheidl, K Weber, and G J Krejs
Gut 2002; 50: 758-764. doi:10.1136/gut.50.6.758 [Abstract] [Full text] [PDF] [Request Permissions]

Timed barium oesophagram: better predictor of long term success after pneumatic dilation in achalasia than symptom assessment
M F Vaezi, M E Baker, E Achkar, and J E Richter
Gut 2002; 50: 765-770. doi:10.1136/gut.50.6.765 [Abstract] [Full text] [PDF] [Request Permissions]

Helicobacter pylori

Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori
S Maeda, H Yoshida, Y Mitsuno, Y Hirata, K Ogura, Y Shiratori, and M Omata
Gut 2002; 50: 771-778. doi:10.1136/gut.50.6.771 [Abstract] [Full text] [PDF] [Request Permissions]

Risk factors for atrophic chronic gastritis in a European population: results of the Eurohepygast study
Gut 2002; 50: 779-785. doi:10.1136/gut.50.6.779 [Abstract] [Full text] [PDF] [Request Permissions]

Effects of N-alpha-methyl-histamine on human H₂ receptors expressed in CHO cells
T Saitoh, Y Fukushima, H Otsuka, M Ishikawa, M Tamai, H Takahashi, H Mori, T Asano, M Anai, T Ishikawa, T Katsube, K Ogawa, T Kajiwara, M Omata, and S Ohkawa
Gut 2002; 50: 786-789. doi:10.1136/gut.50.6.786 [Abstract] [Full text] [PDF] [Request Permissions]

Small intestine

Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/W^V mouse jejunum
I Takayama, Y Daigo, S M Ward, K M Sanders, R L Walker, B Horowitz, T Yamanaka, and M A Fujino
Gut 2002; 50: 790-796. doi:10.1136/gut.50.6.790 [Abstract] [Full text] [PDF] [Request Permissions]

Distribution of the long leptin receptor isoform in brush border, basolateral membrane, and cytoplasm of enterocytes
J Barrenetxe, A C Villaro, L Guembe, I Pascual, M Muñoz-Navas, A Barber, and M P Lostao
Gut 2002; 50: 797-802. doi:10.1136/gut.50.6.797 [Abstract] [Full text] [PDF] [Request Permissions]

Intestinal infection

Lactobacillus acidophilus (strain LB) from the resident adult human gastrointestinal microflora exerts activity against brush border damage promoted by a diarrhoeagenic Escherichia coli in human enterocyte-like cells
V Liévin-Le Moal, R Amsellem, A L Servin, and M-H Coconnier
Gut 2002; 50: 803-811. doi:10.1136/gut.50.6.803 [Abstract] [Full text] [PDF] [Request Permissions]

Inflammation and inflammatory bowel disease

Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage
P V Sivakumar, G M Westrich, S Kanaly, K Garka, T L Born, J M J Derry, and J L Viney
Gut 2002; 50: 812-820. doi:10.1136/gut.50.6.812 [Abstract] [Full text] [PDF] [Request Permissions]

Impairment of epithelial transport but not of barrier function in idiopathic pouchitis after ulcerative colitis
A J Kroesen, M Stockmann, C Ransco, J D Schulzke, M Fromm, and H J Buhr
Gut 2002; 50: 821-826. doi:10.1136/gut.50.6.821 [Abstract] [Full text] [PDF] [Request Permissions]

Cancer

Gastrin-cholecystokinin_B receptor expression in AGS cells is associated with direct inhibition and indirect stimulation of cell proliferation via paracrine activation of the epidermal growth factor receptor
A Varro, P J Noble, L E Wroblewski, L Bishop, and G J Dockray
Gut 2002; 50: 827-833. doi:10.1136/gut.50.6.827 [Abstract] [Full text] [PDF] [Request Permissions]

The spectrum of p53 mutations in colorectal adenomas differs from that in colorectal carcinomas
X P Hao, I M Frayling, J G Sgouros, M Q Du, T C Willcocks, I C Talbot, and I P M Tomlinson
Gut 2002; 50: 834-839. doi:10.1136/gut.50.6.834 [Abstract] [Full text] [PDF] [Request Permissions]

Effect of faecal occult blood screening on mortality from colorectal cancer: results from a randomised controlled trial
J H Scholefield, S Moss, F Sufi, C M Mangham, and J D Hardcastle
Gut 2002; 50: 840-844. doi:10.1136/gut.50.6.840 [Abstract] [Full text] [PDF] [Request Permissions]

Genetic and clinical characterisation of familial adenomatous polyposis: a population based study
A-L Moisio, H Järvinen, and P Peltomäki
Gut 2002; 50: 845-850. doi:10.1136/gut.50.6.845 [Abstract] [Full text] [PDF] [Request Permissions]

Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer
C P Strassburg, A Vogel, S Kneip, R H Tukey, and M P Manns
Gut 2002; 50: 851-856. doi:10.1136/gut.50.6.851 [Abstract] [Full text] [PDF] [Request Permissions]

A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis
R K S Phillips, M H Wallace, P M Lynch, E Hawk, G B Gordon, B P Saunders, N Wakabayashi, Y Shen, S Zimmerman, L Godio, M Rodrigues-Bigas, L-K Su, J Sherman, G Kelloff, B Levin, and G Steinbach
Gut 2002; 50: 857-860. doi:10.1136/gut.50.6.857 [Abstract] [Full text] [PDF] [Request Permissions]

Aberrant p16^INK4A and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma
A V Biankin, S A Biankin, J G Kench, A L Morey, C-S Lee, D R Head, R P Eckstein, T B Hugh, S M Henshall, and R L Sutherland
Gut 2002; 50: 861-868. doi:10.1136/gut.50.6.861 [Abstract] [Full text] [PDF] [Request Permissions]

Liver disease

Selective plasma filtration for treatment of fulminant hepatic failure induced by D-galactosamine in a pig model
D W Y Ho, S T Fan, J To, Y H Woo, Z Zhang, C Lau, and J Wong
Gut 2002; 50: 869-876. doi:10.1136/gut.50.6.869 [Abstract] [Full text] [PDF] [Request Permissions]

Focal nodular hyperplasia of the liver in men: is presentation the same in men and women?
A Luciani, H Kobeiter, P Maison, D Cherqui, E-S Zafrani, D Dhumeaux, and D Mathieu
Gut 2002; 50: 877-880. doi:10.1136/gut.50.6.877 [Abstract] [Full text] [PDF] [Request Permissions]

Staging of hepatocellular carcinoma: assessment of the CLIP, Okuda, and Child-Pugh staging systems in a cohort of 257 patients in Toronto
I Levy and M Sherman
Gut 2002; 50: 881-885. doi:10.1136/gut.50.6.881 [Abstract] [Full text] [PDF] [Request Permissions]

Gut file

A god for guts
J Walker-Smith
Gut 2002; 50: 886-887. doi:10.1136/gut.50.6.886 [Extract] [Full text] [PDF] [Request Permissions]

Occasional viewpoint

Creutzfeldt-Jakob disease: implications for gastroenterology
M G Bramble and J W Ironside
Gut 2002; 50: 888-890. doi:10.1136/gut.50.6.888 [Abstract] [Full text] [PDF] [Request Permissions]

Reviews

Transcriptional regulation of hepatic stellate cell activation
D A Mann and D E Smart
Gut 2002; 50: 891-896. doi:10.1136/gut.50.6.891 [Abstract] [Full text] [PDF] [Request Permissions]

Letters

Hypomagnesaemia due to malabsorption is not always responsive to oral magnesium oxide supplementation alone
R P Arasaradnam and R P Bolton
Gut 2002; 50: 897. doi:10.1136/gut.50.6.897 [Extract] [Full text] [PDF] [Request Permissions]

Regulation of gastric function by gastrin releasing peptide
I L P Beales, C Beglinger, F S Lehmann, and P Hildebrand
Gut 2002; 50: 897-898. doi:10.1136/gut.50.6.897-a [Extract] [Full text] [PDF] [Request Permissions]

Osteoporosis is not a specific complication of primary biliary cirrhosis (PBC)
A Floreani, J L Newton, O F W James, M F Bassendine, and D E J Jones
Gut 2002; 50: 898. doi:10.1136/gut.50.6.898 [Extract] [Full text] [PDF] [Request Permissions]

Expression of isoforms of nitric oxide synthase in collagenous colitis
E A B Cameron, S J Middleton, P J Roberts, A Perner, L Andresen, and J Rask-Madsen
Gut 2002; 50: 899. doi:10.1136/gut.50.6.899 [Extract] [Full text] [PDF] [Request Permissions]

Corrections

CORRECTION
Gut 2002; 50: 899. doi:10.1136/gut.50.6.899-a [Extract] [Full text] [PDF] [Request Permissions]

Cover

High magnification of an Afa/Dr DAEC bacteria associated with multiple elongated microvilli in human intestinal cell (magnification ×8000). (From the paper by Lievin-Le Moal et al, pp 803-811)

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	Primary biliary cirrhosis: seeking the silent partner of autoimmunity I Sutton and J Neuberger Gut 2002; 50: 743-746. doi:10.1136/gut.50.6.743 [Abstract] [Full text] [PDF] [Request Permissions]

	Digest Ian Forgacs Gut 2002; 50: 743. doi:10.1136/gut.50.6.743-a [Extract] [Full text] [PDF] [Request Permissions]

	Easy as 1, 2, 3? Histamine receptors and gastric acid I L P Beales Gut 2002; 50: 747-748. doi:10.1136/gut.50.6.747 [Extract] [Full text] [PDF] [Request Permissions]

	UGT1A1 polymorphisms and colorectal cancer susceptibility N T Brockton Gut 2002; 50: 748-749. doi:10.1136/gut.50.6.748 [Extract] [Full text] [PDF] [Request Permissions]

	HCC: What's the score D Shouval Gut 2002; 50: 749-750. doi:10.1136/gut.50.6.749 [Extract] [Full text] [PDF] [Request Permissions]

	Does chemoradiotherapy after intended curative surgery increase survival of gastric cancer patients? A Cuschieri Gut 2002; 50: 751. doi:10.1136/gut.50.6.751 [Extract] [Full text] [PDF] [Request Permissions]

	Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon M Brittan, T Hunt, R Jeffery, R Poulsom, S J Forbes, K Hodivala-Dilke, J Goldman, M R Alison, and N A Wright Gut 2002; 50: 752-757. doi:10.1136/gut.50.6.752 [Abstract] [Full text] [PDF] [Request Permissions]

	Effect of sildenafil on oesophageal motor function in healthy subjects and patients with oesophageal motor disorders A J Eherer, I Schwetz, H F Hammer, T Petnehazy, S J Scheidl, K Weber, and G J Krejs Gut 2002; 50: 758-764. doi:10.1136/gut.50.6.758 [Abstract] [Full text] [PDF] [Request Permissions]

	Timed barium oesophagram: better predictor of long term success after pneumatic dilation in achalasia than symptom assessment M F Vaezi, M E Baker, E Achkar, and J E Richter Gut 2002; 50: 765-770. doi:10.1136/gut.50.6.765 [Abstract] [Full text] [PDF] [Request Permissions]

	Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori S Maeda, H Yoshida, Y Mitsuno, Y Hirata, K Ogura, Y Shiratori, and M Omata Gut 2002; 50: 771-778. doi:10.1136/gut.50.6.771 [Abstract] [Full text] [PDF] [Request Permissions]

	Risk factors for atrophic chronic gastritis in a European population: results of the Eurohepygast study Gut 2002; 50: 779-785. doi:10.1136/gut.50.6.779 [Abstract] [Full text] [PDF] [Request Permissions]

	Effects of N-alpha-methyl-histamine on human H₂ receptors expressed in CHO cells T Saitoh, Y Fukushima, H Otsuka, M Ishikawa, M Tamai, H Takahashi, H Mori, T Asano, M Anai, T Ishikawa, T Katsube, K Ogawa, T Kajiwara, M Omata, and S Ohkawa Gut 2002; 50: 786-789. doi:10.1136/gut.50.6.786 [Abstract] [Full text] [PDF] [Request Permissions]

	*Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/W^V mouse jejunum* I Takayama, Y Daigo, S M Ward, K M Sanders, R L Walker, B Horowitz, T Yamanaka, and M A Fujino Gut 2002; 50: 790-796. doi:10.1136/gut.50.6.790 [Abstract] [Full text] [PDF] [Request Permissions]

	Distribution of the long leptin receptor isoform in brush border, basolateral membrane, and cytoplasm of enterocytes J Barrenetxe, A C Villaro, L Guembe, I Pascual, M Muñoz-Navas, A Barber, and M P Lostao Gut 2002; 50: 797-802. doi:10.1136/gut.50.6.797 [Abstract] [Full text] [PDF] [Request Permissions]

	Lactobacillus acidophilus (strain LB) from the resident adult human gastrointestinal microflora exerts activity against brush border damage promoted by a diarrhoeagenic Escherichia coli in human enterocyte-like cells V Liévin-Le Moal, R Amsellem, A L Servin, and M-H Coconnier Gut 2002; 50: 803-811. doi:10.1136/gut.50.6.803 [Abstract] [Full text] [PDF] [Request Permissions]

	Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage P V Sivakumar, G M Westrich, S Kanaly, K Garka, T L Born, J M J Derry, and J L Viney Gut 2002; 50: 812-820. doi:10.1136/gut.50.6.812 [Abstract] [Full text] [PDF] [Request Permissions]

	Impairment of epithelial transport but not of barrier function in idiopathic pouchitis after ulcerative colitis A J Kroesen, M Stockmann, C Ransco, J D Schulzke, M Fromm, and H J Buhr Gut 2002; 50: 821-826. doi:10.1136/gut.50.6.821 [Abstract] [Full text] [PDF] [Request Permissions]

	Gastrin-cholecystokinin_B receptor expression in AGS cells is associated with direct inhibition and indirect stimulation of cell proliferation via paracrine activation of the epidermal growth factor receptor A Varro, P J Noble, L E Wroblewski, L Bishop, and G J Dockray Gut 2002; 50: 827-833. doi:10.1136/gut.50.6.827 [Abstract] [Full text] [PDF] [Request Permissions]

	The spectrum of p53 mutations in colorectal adenomas differs from that in colorectal carcinomas X P Hao, I M Frayling, J G Sgouros, M Q Du, T C Willcocks, I C Talbot, and I P M Tomlinson Gut 2002; 50: 834-839. doi:10.1136/gut.50.6.834 [Abstract] [Full text] [PDF] [Request Permissions]

	Effect of faecal occult blood screening on mortality from colorectal cancer: results from a randomised controlled trial J H Scholefield, S Moss, F Sufi, C M Mangham, and J D Hardcastle Gut 2002; 50: 840-844. doi:10.1136/gut.50.6.840 [Abstract] [Full text] [PDF] [Request Permissions]

	Genetic and clinical characterisation of familial adenomatous polyposis: a population based study A-L Moisio, H Järvinen, and P Peltomäki Gut 2002; 50: 845-850. doi:10.1136/gut.50.6.845 [Abstract] [Full text] [PDF] [Request Permissions]

	*Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7* gene in colorectal cancer** C P Strassburg, A Vogel, S Kneip, R H Tukey, and M P Manns Gut 2002; 50: 851-856. doi:10.1136/gut.50.6.851 [Abstract] [Full text] [PDF] [Request Permissions]

	A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis R K S Phillips, M H Wallace, P M Lynch, E Hawk, G B Gordon, B P Saunders, N Wakabayashi, Y Shen, S Zimmerman, L Godio, M Rodrigues-Bigas, L-K Su, J Sherman, G Kelloff, B Levin, and G Steinbach Gut 2002; 50: 857-860. doi:10.1136/gut.50.6.857 [Abstract] [Full text] [PDF] [Request Permissions]

	*Aberrant p16^INK4A and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma* A V Biankin, S A Biankin, J G Kench, A L Morey, C-S Lee, D R Head, R P Eckstein, T B Hugh, S M Henshall, and R L Sutherland Gut 2002; 50: 861-868. doi:10.1136/gut.50.6.861 [Abstract] [Full text] [PDF] [Request Permissions]

	Selective plasma filtration for treatment of fulminant hepatic failure induced by D-galactosamine in a pig model D W Y Ho, S T Fan, J To, Y H Woo, Z Zhang, C Lau, and J Wong Gut 2002; 50: 869-876. doi:10.1136/gut.50.6.869 [Abstract] [Full text] [PDF] [Request Permissions]

	Focal nodular hyperplasia of the liver in men: is presentation the same in men and women? A Luciani, H Kobeiter, P Maison, D Cherqui, E-S Zafrani, D Dhumeaux, and D Mathieu Gut 2002; 50: 877-880. doi:10.1136/gut.50.6.877 [Abstract] [Full text] [PDF] [Request Permissions]

	Staging of hepatocellular carcinoma: assessment of the CLIP, Okuda, and Child-Pugh staging systems in a cohort of 257 patients in Toronto I Levy and M Sherman Gut 2002; 50: 881-885. doi:10.1136/gut.50.6.881 [Abstract] [Full text] [PDF] [Request Permissions]

	A god for guts J Walker-Smith Gut 2002; 50: 886-887. doi:10.1136/gut.50.6.886 [Extract] [Full text] [PDF] [Request Permissions]

	Creutzfeldt-Jakob disease: implications for gastroenterology M G Bramble and J W Ironside Gut 2002; 50: 888-890. doi:10.1136/gut.50.6.888 [Abstract] [Full text] [PDF] [Request Permissions]

	Transcriptional regulation of hepatic stellate cell activation D A Mann and D E Smart Gut 2002; 50: 891-896. doi:10.1136/gut.50.6.891 [Abstract] [Full text] [PDF] [Request Permissions]

	Hypomagnesaemia due to malabsorption is not always responsive to oral magnesium oxide supplementation alone R P Arasaradnam and R P Bolton Gut 2002; 50: 897. doi:10.1136/gut.50.6.897 [Extract] [Full text] [PDF] [Request Permissions]

	Regulation of gastric function by gastrin releasing peptide I L P Beales, C Beglinger, F S Lehmann, and P Hildebrand Gut 2002; 50: 897-898. doi:10.1136/gut.50.6.897-a [Extract] [Full text] [PDF] [Request Permissions]

	Osteoporosis is not a specific complication of primary biliary cirrhosis (PBC) A Floreani, J L Newton, O F W James, M F Bassendine, and D E J Jones Gut 2002; 50: 898. doi:10.1136/gut.50.6.898 [Extract] [Full text] [PDF] [Request Permissions]

	Expression of isoforms of nitric oxide synthase in collagenous colitis E A B Cameron, S J Middleton, P J Roberts, A Perner, L Andresen, and J Rask-Madsen Gut 2002; 50: 899. doi:10.1136/gut.50.6.899 [Extract] [Full text] [PDF] [Request Permissions]

	CORRECTION Gut 2002; 50: 899. doi:10.1136/gut.50.6.899-a [Extract] [Full text] [PDF] [Request Permissions]