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September 2002 (Volume 51, Number 3). [Index by author]

	(Cover illustration)	Leading articles Digest Commentaries Clinical @lert Science @lert Debate Barrett's oesophagus Stomach Therapy update Gut immunology Inflammation and inflammatory bowel disease Irritable bowel syndrome and the enteric nervous system Colorectal cancer Liver disease Case reports Reviews Letters

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Leading articles

T-bet and mucosal Th1 responses in the gastrointestinal tract
B Weigmann and M F Neurath
Gut 2002; 51: 301-303. doi:10.1136/gut.51.3.301 [Abstract] [Full text] [PDF] [Request Permissions]

Digest

Digest
Ian Forgacs
Gut 2002; 51: 301. doi:10.1136/gut.51.3.301-a [Extract] [Full text] [PDF] [Request Permissions]

Commentaries

From hyperplasia to T cell lymphoma
N Cerf-Bensussan, N Brousse, and C Cellier
Gut 2002; 51: 304-305. doi:10.1136/gut.51.3.304 [Extract] [Full text] [PDF] [Request Permissions]

Infection and irritability
R Lea and P J Whorwell
Gut 2002; 51: 305-306. doi:10.1136/gut.51.3.305 [Extract] [Full text] [PDF] [Request Permissions]

Top down or bottom up? Competing management structures in the morphogenesis of colorectal neoplasms
N A Wright and R Poulsom
Gut 2002; 51: 306-308. doi:10.1136/gut.51.3.306 [Extract] [Full text] [PDF] [Request Permissions]

Clinical @lert

Helping patients to help themselves: the future for management of ulcerative colitis?
P Moayyedi
Gut 2002; 51: 309-310. doi:10.1136/gut.51.3.309 [Extract] [Full text] [PDF] [Request Permissions]

Science @lert

Suppressor T cells, rebranded as regulatory T cells, emerge from the wilderness bearing surface markers
T T MacDonald
Gut 2002; 51: 311-312. doi:10.1136/gut.51.3.311 [Extract] [Full text] [PDF] [Request Permissions]

Debate

Endoscopic surveillance of patients with Barrett’s oesophagus
H Barr
Gut 2002; 51: 313-314. doi:10.1136/gut.51.3.313 [Extract] [Full text] [PDF] [Request Permissions]

Endoscopic surveillance of patients with Barrett’s oesophagus
R J Playford
Gut 2002; 51: 314-315. doi:10.1136/gut.51.3.314 [Extract] [Full text] [PDF] [Request Permissions]

Barrett's oesophagus

Inflammatory gradient in Barrett’s oesophagus: implications for disease complications
R C Fitzgerald, S Abdalla, B A Onwuegbusi, P Sirieix, I T Saeed, W R Burnham, and M J G Farthing
Gut 2002; 51: 316-322. doi:10.1136/gut.51.3.316 [Abstract] [Full text] [PDF] [Request Permissions]

Familial aggregation of Barrett’s oesophagus, oesophageal adenocarcinoma, and oesophagogastric junctional adenocarcinoma in Caucasian adults
A Chak, T Lee, M F Kinnard, W Brock, A Faulx, J Willis, G S Cooper, M V Sivak, Jr, and K A B Goddard
Gut 2002; 51: 323-328. doi:10.1136/gut.51.3.323 [Abstract] [Full text] [PDF] [Request Permissions]

Stomach

Primary prevention of diclofenac associated ulcers and dyspepsia by omeprazole or triple therapy in Helicobacter pylori positive patients: a randomised, double blind, placebo controlled, clinical trial
J Labenz, A L Blum, W W Bolten, B Dragosics, W Rösch, M Stolte, and H R Koelz
Gut 2002; 51: 329-335. doi:10.1136/gut.51.3.329 [Abstract] [Full text] [PDF] [Request Permissions]

Relative contribution of mucosal injury and Helicobacter pylori in the development of gastroduodenal lesions in patients taking non-steroidal anti-inflammatory drugs
C J Hawkey, J Næsdal, I Wilson, G Långström, A J Swannell, R A Peacock, and N D Yeomans
Gut 2002; 51: 336-343. doi:10.1136/gut.51.3.336 [Abstract] [Full text] [PDF] [Request Permissions]

Influence of sex and Helicobacter pylori on development and healing of gastroduodenal lesions in non-steroidal anti-inflammatory drug users
C J Hawkey, I Wilson, J Næsdal, G Långström, A J Swannell, and N D Yeomans
Gut 2002; 51: 344-350. doi:10.1136/gut.51.3.344 [Abstract] [Full text] [PDF] [Request Permissions]

Bile reflux gastritis and intestinal metaplasia at the cardia
M F Dixon, N P Mapstone, P M Neville, P Moayyedi, and A T R Axon
Gut 2002; 51: 351-355. doi:10.1136/gut.51.3.351 [Abstract] [Full text] [PDF] [Request Permissions]

Modulation of host antimicrobial peptide (ß-defensins 1 and 2) expression during gastritis
M Bajaj-Elliott, P Fedeli, G V Smith, P Domizio, L Maher, R S Ali, A G Quinn, and M J G Farthing
Gut 2002; 51: 356-361. doi:10.1136/gut.51.3.356 [Abstract] [Full text] [PDF] [Request Permissions]

Therapy update

Anti-tumour necrosis factor therapy in Crohn’s disease: where are we now?
S J H van Deventer
Gut 2002; 51: 362-363. doi:10.1136/gut.51.3.362 [Extract] [Full text] [PDF] [Request Permissions]

Gut immunology

B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue
H S Carlsen, E S Baekkevold, F-E Johansen, G Haraldsen, and P Brandtzaeg
Gut 2002; 51: 364-371. doi:10.1136/gut.51.3.364 [Abstract] [Full text] [PDF] [Request Permissions]

Heterogeneity of intraepithelial lymphocytes in refractory sprue: potential implications of CD30 expression
I N Farstad, F-E Johansen, L Vlatkovic, J Jahnsen, H Scott, O Fausa, A Bjørneklett, P Brandtzaeg, and T S Halstensen
Gut 2002; 51: 372-378. doi:10.1136/gut.51.3.372 [Abstract] [Full text] [PDF] [Request Permissions]

Inflammation and inflammatory bowel disease

Activation of signal transducer and activator of transcription (STAT) 1 in human chronic inflammatory bowel disease
S Schreiber, P Rosenstiel, J Hampe, S Nikolaus, B Groessner, A Schottelius, T Kühbacher, J Hämling, U R Fölsch, and D Seegert
Gut 2002; 51: 379-385. doi:10.1136/gut.51.3.379 [Abstract] [Full text] [PDF] [Request Permissions]

Mucin gene expression in the ileoanal reservoir is altered and may be relevant to the risk of inflammation and dysplasia
P A Sylvester, M Walsh, N Myerscough, B F Warren, A P Corfield, M G Thomas, and P Durdey
Gut 2002; 51: 386-391. doi:10.1136/gut.51.3.386 [Abstract] [Full text] [PDF] [Request Permissions]

Regression of Peyer's patches in G ${alpha}$ i2 deficient mice prior to colitis is associated with reduced expression of Bcl-2 and increased apoptosis
L Öhman, L Franzén, U Rudolph, L Birnbaumer, and E Hultgren Hörnquist
Gut 2002; 51: 392-397. doi:10.1136/gut.51.3.392 [Abstract] [Full text] [PDF] [Request Permissions]

Overexpression of ${alpha}$ ₁-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis
T Hochepied, A Wullaert, F G Berger, H Baumann, P Brouckaert, L Steidler, and C Libert
Gut 2002; 51: 398-404. doi:10.1136/gut.51.3.398 [Abstract] [Full text] [PDF] [Request Permissions]

Ineffectiveness of probiotics in preventing recurrence after curative resection for Crohn's disease: a randomised controlled trial with Lactobacillus GG
C Prantera, M L Scribano, G Falasco, A Andreoli, and C Luzi
Gut 2002; 51: 405-409. doi:10.1136/gut.51.3.405 [Abstract] [Full text] [PDF] [Request Permissions]

Irritable bowel syndrome and the enteric nervous system

Prognosis in post-infective irritable bowel syndrome: a six year follow up study
K R Neal, L Barker, and R C Spiller
Gut 2002; 51: 410-413. doi:10.1136/gut.51.3.410 [Abstract] [Full text] [PDF] [Request Permissions]

Abnormalities of the enteric nervous system in heterozygous endothelin B receptor deficient (spotting lethal) rats resembling intestinal neuronal dysplasia
G B T von Boyen, H-J Krammer, A Süss, C Dembowski, H Ehrenreich, and T Wedel
Gut 2002; 51: 414-419. doi:10.1136/gut.51.3.414 [Abstract] [Full text] [PDF] [Request Permissions]

Colorectal cancer

Explaining variation in familial adenomatous polyposis: relationship between genotype and phenotype and evidence for modifier genes
M D Crabtree, I P M Tomlinson, S V Hodgson, K Neale, R K S Phillips, and R S Houlston
Gut 2002; 51: 420-423. doi:10.1136/gut.51.3.420 [Abstract] [Full text] [PDF] [Request Permissions]

Risk related surveillance following colorectal polypectomy
G Nusko, U Mansmann, Th Kirchner, and E G Hahn
Gut 2002; 51: 424-428. doi:10.1136/gut.51.3.424 [Abstract] [Full text] [PDF] [Request Permissions]

Liver disease

Prevalence and risk factors of hepatitis C virus infection in haemodialysis patients: a multicentre study in 2796 patients
H Hinrichsen, G Leimenstoll, G Stegen, H Schrader, U R Fölsch, and W E Schmidt
Gut 2002; 51: 429-433. doi:10.1136/gut.51.3.429 [Abstract] [Full text] [PDF] [Request Permissions]

Fatigue is associated with high circulating leptin levels in chronic hepatitis C
T Piche, E Gelsi, S M Schneider, X Hébuterne, J Giudicelli, B Ferrua, C Laffont, S Benzaken, P Hastier, M L Montoya, F Longo, P Rampal, and A Tran
Gut 2002; 51: 434-439. doi:10.1136/gut.51.3.434 [Abstract] [Full text] [PDF] [Request Permissions]

In vivo gene transfer of endothelial nitric oxide synthase decreases portal pressure in anaesthetised carbon tetrachloride cirrhotic rats
M Van de Casteele, A Omasta, S Janssens, T Roskams, V Desmet, F Nevens, and J Fevery
Gut 2002; 51: 440-445. doi:10.1136/gut.51.3.440 [Abstract] [Full text] [PDF] [Request Permissions]

Case reports

Intraductal papillary and mucinous pancreatic tumour: a new extracolonic tumour in familial adenomatous polyposis
F Maire, P Hammel, B Terris, S Olschwang, D O'Toole, A Sauvanet, L Palazzo, P Ponsot, B Laplane, P Lévy, and P Ruszniewski
Gut 2002; 51: 446-449. doi:10.1136/gut.51.3.446 [Abstract] [Full text] [PDF] [Request Permissions]

Reviews

Homeobox genes in gut development
F Beck
Gut 2002; 51: 450-454. doi:10.1136/gut.51.3.450 [Abstract] [Full text] [PDF] [Request Permissions]

Letters

Invasive or non-invasive methods for the diagnosis of subclinical coeliac disease?
A Tursi, C B Pearce, H D Duncan, D Sinclair, and D N Poller
Gut 2002; 51: 455-456. doi:10.1136/gut.51.3.455 [Extract] [Full text] [PDF] [Request Permissions]

Intravenous immunoglobulin for recurrent Clostridium difficile diarrhoea
I L P Beales
Gut 2002; 51: 456. doi:10.1136/gut.51.3.456 [Extract] [Full text] [PDF] [Request Permissions]

Surveillance for hepatocellular carcinoma in liver cirrhosis: have programmes improved because patients have?
E Giannini and R Testa
Gut 2002; 51: 456-457. doi:10.1136/gut.51.3.456-a [Extract] [Full text] [PDF] [Request Permissions]

Gastric cancer and H pylori
S M Dawsey, S D Mark, P R Taylor, and P J Limburg
Gut 2002; 51: 457-458. doi:10.1136/gut.51.3.457 [Extract] [Full text] [PDF] [Request Permissions]

Cover

Light level micrograph showing a germinal centre in a Peyer's patch of a G-&agr;-i2 deficient mouse. (From the paper by Öhman et al , pp 392 –7.)

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	T-bet and mucosal Th1 responses in the gastrointestinal tract B Weigmann and M F Neurath Gut 2002; 51: 301-303. doi:10.1136/gut.51.3.301 [Abstract] [Full text] [PDF] [Request Permissions]

	Digest Ian Forgacs Gut 2002; 51: 301. doi:10.1136/gut.51.3.301-a [Extract] [Full text] [PDF] [Request Permissions]

	From hyperplasia to T cell lymphoma N Cerf-Bensussan, N Brousse, and C Cellier Gut 2002; 51: 304-305. doi:10.1136/gut.51.3.304 [Extract] [Full text] [PDF] [Request Permissions]

	Infection and irritability R Lea and P J Whorwell Gut 2002; 51: 305-306. doi:10.1136/gut.51.3.305 [Extract] [Full text] [PDF] [Request Permissions]

	Top down or bottom up? Competing management structures in the morphogenesis of colorectal neoplasms N A Wright and R Poulsom Gut 2002; 51: 306-308. doi:10.1136/gut.51.3.306 [Extract] [Full text] [PDF] [Request Permissions]

	Helping patients to help themselves: the future for management of ulcerative colitis? P Moayyedi Gut 2002; 51: 309-310. doi:10.1136/gut.51.3.309 [Extract] [Full text] [PDF] [Request Permissions]

	Suppressor T cells, rebranded as regulatory T cells, emerge from the wilderness bearing surface markers T T MacDonald Gut 2002; 51: 311-312. doi:10.1136/gut.51.3.311 [Extract] [Full text] [PDF] [Request Permissions]

	Endoscopic surveillance of patients with Barrett’s oesophagus H Barr Gut 2002; 51: 313-314. doi:10.1136/gut.51.3.313 [Extract] [Full text] [PDF] [Request Permissions]

	Endoscopic surveillance of patients with Barrett’s oesophagus R J Playford Gut 2002; 51: 314-315. doi:10.1136/gut.51.3.314 [Extract] [Full text] [PDF] [Request Permissions]

	Inflammatory gradient in Barrett’s oesophagus: implications for disease complications R C Fitzgerald, S Abdalla, B A Onwuegbusi, P Sirieix, I T Saeed, W R Burnham, and M J G Farthing Gut 2002; 51: 316-322. doi:10.1136/gut.51.3.316 [Abstract] [Full text] [PDF] [Request Permissions]

	Familial aggregation of Barrett’s oesophagus, oesophageal adenocarcinoma, and oesophagogastric junctional adenocarcinoma in Caucasian adults A Chak, T Lee, M F Kinnard, W Brock, A Faulx, J Willis, G S Cooper, M V Sivak, Jr, and K A B Goddard Gut 2002; 51: 323-328. doi:10.1136/gut.51.3.323 [Abstract] [Full text] [PDF] [Request Permissions]

	Primary prevention of diclofenac associated ulcers and dyspepsia by omeprazole or triple therapy in Helicobacter pylori positive patients: a randomised, double blind, placebo controlled, clinical trial J Labenz, A L Blum, W W Bolten, B Dragosics, W Rösch, M Stolte, and H R Koelz Gut 2002; 51: 329-335. doi:10.1136/gut.51.3.329 [Abstract] [Full text] [PDF] [Request Permissions]

	*Relative contribution of mucosal injury and Helicobacter pylori* in the development of gastroduodenal lesions in patients taking non-steroidal anti-inflammatory drugs** C J Hawkey, J Næsdal, I Wilson, G Långström, A J Swannell, R A Peacock, and N D Yeomans Gut 2002; 51: 336-343. doi:10.1136/gut.51.3.336 [Abstract] [Full text] [PDF] [Request Permissions]

	*Influence of sex and Helicobacter pylori* on development and healing of gastroduodenal lesions in non-steroidal anti-inflammatory drug users** C J Hawkey, I Wilson, J Næsdal, G Långström, A J Swannell, and N D Yeomans Gut 2002; 51: 344-350. doi:10.1136/gut.51.3.344 [Abstract] [Full text] [PDF] [Request Permissions]

	Bile reflux gastritis and intestinal metaplasia at the cardia M F Dixon, N P Mapstone, P M Neville, P Moayyedi, and A T R Axon Gut 2002; 51: 351-355. doi:10.1136/gut.51.3.351 [Abstract] [Full text] [PDF] [Request Permissions]

	Modulation of host antimicrobial peptide (ß-defensins 1 and 2) expression during gastritis M Bajaj-Elliott, P Fedeli, G V Smith, P Domizio, L Maher, R S Ali, A G Quinn, and M J G Farthing Gut 2002; 51: 356-361. doi:10.1136/gut.51.3.356 [Abstract] [Full text] [PDF] [Request Permissions]

	Anti-tumour necrosis factor therapy in Crohn’s disease: where are we now? S J H van Deventer Gut 2002; 51: 362-363. doi:10.1136/gut.51.3.362 [Extract] [Full text] [PDF] [Request Permissions]

	B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue H S Carlsen, E S Baekkevold, F-E Johansen, G Haraldsen, and P Brandtzaeg Gut 2002; 51: 364-371. doi:10.1136/gut.51.3.364 [Abstract] [Full text] [PDF] [Request Permissions]

	Heterogeneity of intraepithelial lymphocytes in refractory sprue: potential implications of CD30 expression I N Farstad, F-E Johansen, L Vlatkovic, J Jahnsen, H Scott, O Fausa, A Bjørneklett, P Brandtzaeg, and T S Halstensen Gut 2002; 51: 372-378. doi:10.1136/gut.51.3.372 [Abstract] [Full text] [PDF] [Request Permissions]

	Activation of signal transducer and activator of transcription (STAT) 1 in human chronic inflammatory bowel disease S Schreiber, P Rosenstiel, J Hampe, S Nikolaus, B Groessner, A Schottelius, T Kühbacher, J Hämling, U R Fölsch, and D Seegert Gut 2002; 51: 379-385. doi:10.1136/gut.51.3.379 [Abstract] [Full text] [PDF] [Request Permissions]

	Mucin gene expression in the ileoanal reservoir is altered and may be relevant to the risk of inflammation and dysplasia P A Sylvester, M Walsh, N Myerscough, B F Warren, A P Corfield, M G Thomas, and P Durdey Gut 2002; 51: 386-391. doi:10.1136/gut.51.3.386 [Abstract] [Full text] [PDF] [Request Permissions]

	Regression of Peyer's patches in G ${alpha}$ i2 deficient mice prior to colitis is associated with reduced expression of Bcl-2 and increased apoptosis L Öhman, L Franzén, U Rudolph, L Birnbaumer, and E Hultgren Hörnquist Gut 2002; 51: 392-397. doi:10.1136/gut.51.3.392 [Abstract] [Full text] [PDF] [Request Permissions]

	Overexpression of ${alpha}$ ₁-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis T Hochepied, A Wullaert, F G Berger, H Baumann, P Brouckaert, L Steidler, and C Libert Gut 2002; 51: 398-404. doi:10.1136/gut.51.3.398 [Abstract] [Full text] [PDF] [Request Permissions]

	*Ineffectiveness of probiotics in preventing recurrence after curative resection for Crohn's disease: a randomised controlled trial with Lactobacillus* GG** C Prantera, M L Scribano, G Falasco, A Andreoli, and C Luzi Gut 2002; 51: 405-409. doi:10.1136/gut.51.3.405 [Abstract] [Full text] [PDF] [Request Permissions]

	Prognosis in post-infective irritable bowel syndrome: a six year follow up study K R Neal, L Barker, and R C Spiller Gut 2002; 51: 410-413. doi:10.1136/gut.51.3.410 [Abstract] [Full text] [PDF] [Request Permissions]

	Abnormalities of the enteric nervous system in heterozygous endothelin B receptor deficient (spotting lethal) rats resembling intestinal neuronal dysplasia G B T von Boyen, H-J Krammer, A Süss, C Dembowski, H Ehrenreich, and T Wedel Gut 2002; 51: 414-419. doi:10.1136/gut.51.3.414 [Abstract] [Full text] [PDF] [Request Permissions]

	Explaining variation in familial adenomatous polyposis: relationship between genotype and phenotype and evidence for modifier genes M D Crabtree, I P M Tomlinson, S V Hodgson, K Neale, R K S Phillips, and R S Houlston Gut 2002; 51: 420-423. doi:10.1136/gut.51.3.420 [Abstract] [Full text] [PDF] [Request Permissions]

	Risk related surveillance following colorectal polypectomy G Nusko, U Mansmann, Th Kirchner, and E G Hahn Gut 2002; 51: 424-428. doi:10.1136/gut.51.3.424 [Abstract] [Full text] [PDF] [Request Permissions]

	Prevalence and risk factors of hepatitis C virus infection in haemodialysis patients: a multicentre study in 2796 patients H Hinrichsen, G Leimenstoll, G Stegen, H Schrader, U R Fölsch, and W E Schmidt Gut 2002; 51: 429-433. doi:10.1136/gut.51.3.429 [Abstract] [Full text] [PDF] [Request Permissions]

	Fatigue is associated with high circulating leptin levels in chronic hepatitis C T Piche, E Gelsi, S M Schneider, X Hébuterne, J Giudicelli, B Ferrua, C Laffont, S Benzaken, P Hastier, M L Montoya, F Longo, P Rampal, and A Tran Gut 2002; 51: 434-439. doi:10.1136/gut.51.3.434 [Abstract] [Full text] [PDF] [Request Permissions]

	In vivo gene transfer of endothelial nitric oxide synthase decreases portal pressure in anaesthetised carbon tetrachloride cirrhotic rats M Van de Casteele, A Omasta, S Janssens, T Roskams, V Desmet, F Nevens, and J Fevery Gut 2002; 51: 440-445. doi:10.1136/gut.51.3.440 [Abstract] [Full text] [PDF] [Request Permissions]

	Intraductal papillary and mucinous pancreatic tumour: a new extracolonic tumour in familial adenomatous polyposis F Maire, P Hammel, B Terris, S Olschwang, D O'Toole, A Sauvanet, L Palazzo, P Ponsot, B Laplane, P Lévy, and P Ruszniewski Gut 2002; 51: 446-449. doi:10.1136/gut.51.3.446 [Abstract] [Full text] [PDF] [Request Permissions]

	Homeobox genes in gut development F Beck Gut 2002; 51: 450-454. doi:10.1136/gut.51.3.450 [Abstract] [Full text] [PDF] [Request Permissions]

	Invasive or non-invasive methods for the diagnosis of subclinical coeliac disease? A Tursi, C B Pearce, H D Duncan, D Sinclair, and D N Poller Gut 2002; 51: 455-456. doi:10.1136/gut.51.3.455 [Extract] [Full text] [PDF] [Request Permissions]

	*Intravenous immunoglobulin for recurrent Clostridium difficile* diarrhoea** I L P Beales Gut 2002; 51: 456. doi:10.1136/gut.51.3.456 [Extract] [Full text] [PDF] [Request Permissions]

	Surveillance for hepatocellular carcinoma in liver cirrhosis: have programmes improved because patients have? E Giannini and R Testa Gut 2002; 51: 456-457. doi:10.1136/gut.51.3.456-a [Extract] [Full text] [PDF] [Request Permissions]

	Gastric cancer and H pylori S M Dawsey, S D Mark, P R Taylor, and P J Limburg Gut 2002; 51: 457-458. doi:10.1136/gut.51.3.457 [Extract] [Full text] [PDF] [Request Permissions]