Leading articles

	Hepatocellular carcinoma: is current therapy really altering outcome? P J Johnson Gut 2002; 51: 459-462. doi:10.1136/gut.51.4.459 [Abstract] [Full text] [PDF] [Request Permissions]

Digest

	Digest Ian Forgacs Gut 2002; 51: 459. doi:10.1136/gut.51.4.459-a [Extract] [Full text] [PDF] [Request Permissions]

Commentaries

	FAP: another indication to treat H pylori B Leggett Gut 2002; 51: 463-464. doi:10.1136/gut.51.4.463 [Extract] [Full text] [PDF] [Request Permissions]
	Functional dyspepsia: bye-bye to PPIs O Nyrén Gut 2002; 51: 464-465. doi:10.1136/gut.51.4.464 [Extract] [Full text] [PDF] [Request Permissions]

Clinical @lert

	Do those with positive faecal occult blood tests need upper gastrointestinal investigations if no colorectal cancer cause is found? M H Robinson Gut 2002; 51: 466-467. doi:10.1136/gut.51.4.466 [Extract] [Full text] [PDF] [Request Permissions]

Debate

	Laparoscopic fundoplication is the treatment of choice for gastro-oesophageal reflux disease L Lundell Gut 2002; 51: 468-471. doi:10.1136/gut.51.4.468 [Extract] [Full text] [PDF] [Request Permissions]
	Laparoscopic fundoplication is the treatment of choice for gastro-oesophageal reflux disease J P Galmiche and F Zerbib Gut 2002; 51: 472-474. doi:10.1136/gut.51.4.472 [Extract] [Full text] [PDF] [Request Permissions]

Gastro-oesophageal reflux

	Mechanisms of gastro-oesophageal reflux in preterm and term infants with reflux disease T I Omari, C P Barnett, M A Benninga, R Lontis, L Goodchild, R R Haslam, J Dent, and G P Davidson Gut 2002; 51: 475-479. doi:10.1136/gut.51.4.475 [Abstract] [Full text] [PDF] [Request Permissions]

Helicobacter pylori

	Relationship between Helicobacter pylori babA2 status with gastric epithelial cell turnover and premalignant gastric lesions J Yu, W K Leung, M Y Y Go, M C W Chan, K F To, E K W Ng, F K L Chan, T K W Ling, S C S Chung, and J J Y Sung Gut 2002; 51: 480-484. doi:10.1136/gut.51.4.480 [Abstract] [Full text] [PDF] [Request Permissions]
	Impact of Helicobacter pylori infection and mucosal atrophy on gastric lesions in patients with familial adenomatous polyposis S Nakamura, T Matsumoto, Y Kobori, and M Iida Gut 2002; 51: 485-489. doi:10.1136/gut.51.4.485 [Abstract] [Full text] [PDF] [Request Permissions]
	Impact of acid secretion, gastritis, and mucus thickness on gastric transfer of antibiotics in rats P V Sherwood, J I D Wibawa, J C Atherton, N Jordan, D Jenkins, D A Barrett, P N Shaw, and R C Spiller Gut 2002; 51: 490-495. doi:10.1136/gut.51.4.490 [Abstract] [Full text] [PDF] [Request Permissions]

Motility and visceral sensation

	Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation G L Lyford, C-L He, E Soffer, T L Hull, S A Strong, A J Senagore, L J Burgart, T Young-Fadok, J H Szurszewski, and G Farrugia Gut 2002; 51: 496-501. doi:10.1136/gut.51.4.496 [Abstract] [Full text] [PDF] [Request Permissions]
	Double blind, randomised, placebo controlled study of four weeks of lansoprazole for the treatment of functional dyspepsia in Chinese patients W M Wong, B C Y Wong, W K Hung, Y K Yee, A W C Yip, M L Szeto, F M Y Fung, T S M Tong, K C Lai, W H C Hu, M F Yuen, and S K Lam Gut 2002; 51: 502-506. doi:10.1136/gut.51.4.502 [Abstract] [Full text] [PDF] [Request Permissions]

Small intestine

	Effect of stress on the paracellular barrier in the rat ileum E Mazzon, G C Sturniolo, D Puzzolo, N Frisina, and W Fries Gut 2002; 51: 507-513. doi:10.1136/gut.51.4.507 [Abstract] [Full text] [PDF] [Request Permissions]
	Autophagocytosis of the apical membrane in microvillus inclusion disease K Reinshagen, H Y Naim, and K-P Zimmer Gut 2002; 51: 514-521. doi:10.1136/gut.51.4.514 [Abstract] [Full text] [PDF] [Request Permissions]
	Antidiarrhoeal properties of a novel sigma ligand (JO 2871) on toxigenic diarrhoea in mice: mechanisms of action V Theodorou, M Chovet, H Eutamene, H Fargeau, M Dassaud, M Toulouse, C Bihoreau, F J Roman, and L Bueno Gut 2002; 51: 522-528. doi:10.1136/gut.51.4.522 [Abstract] [Full text] [PDF] [Request Permissions]

Inflammation and inflammatory bowel disease

	ICAM-1 and VCAM-1 antisense oligonucleotides attenuate in vivo leucocyte adherence and inflammation in rat inflammatory bowel disease E Rijcken, C F Krieglstein, C Anthoni, M G Laukoetter, R Mennigen, H U Spiegel, N Senninger, C F Bennett, and G Schuermann Gut 2002; 51: 529-535. doi:10.1136/gut.51.4.529 [Abstract] [Full text] [PDF] [Request Permissions]
	Sulphasalazine and mesalazine: serious adverse reactions re-evaluated on the basis of suspected adverse reaction reports to the Committee on Safety of Medicines R A J Ransford and M J S Langman Gut 2002; 51: 536-539. doi:10.1136/gut.51.4.536 [Abstract] [Full text] [PDF] [Request Permissions]
	Upregulation of matrix metalloproteinases in a model of T cell mediated tissue injury in the gut: analysis by gene array and in situ hybridisation M T Salmela, T T MacDonald, D Black, B Irvine, T Zhuma, U Saarialho-Kere, and S L F Pender Gut 2002; 51: 540-547. doi:10.1136/gut.51.4.540 [Abstract] [Full text] [PDF] [Request Permissions]

Therapy update

	Which 5-ASA? S P L Travis Gut 2002; 51: 548-549. doi:10.1136/gut.51.4.548 [Extract] [Full text] [PDF] [Request Permissions]

Cancer

	Flat and depressed colorectal tumours in a southern Swedish population: a prospective chromoendoscopic and histopathological study S Tsuda, B Veress, E Tóth, and F-T Fork Gut 2002; 51: 550-555. doi:10.1136/gut.51.4.550 [Abstract] [Full text] [PDF] [Request Permissions]
	Pk11195, a mitochondrial benzodiazepine receptor antagonist, reduces apoptosis threshold in Bcl-XL and Mcl-1 expressing human cholangiocarcinoma cells A C Okaro, D A Fennell, M Corbo, B R Davidson, and F E Cotter Gut 2002; 51: 556-561. doi:10.1136/gut.51.4.556 [Abstract] [Full text] [PDF] [Request Permissions]
	Natural history of primary sclerosing cholangitis and prognostic value of cholangiography in a Dutch population C Y Ponsioen, S M E Vrouenraets, W Prawirodirdjo, R Rajaram, E A J Rauws, C J J Mulder, J B Reitsma, S H Heisterkamp, and G N J Tytgat Gut 2002; 51: 562-566. doi:10.1136/gut.51.4.562 [Abstract] [Full text] [PDF] [Request Permissions]
	Cigarette smoking, appendectomy, and tonsillectomy as risk factors for the development of primary sclerosing cholangitis: a case control study S A Mitchell, M Thyssen, T R Orchard, D P Jewell, K A Fleming, and R W Chapman Gut 2002; 51: 567-573. doi:10.1136/gut.51.4.567 [Abstract] [Full text] [PDF] [Request Permissions]

Pancreatic disease

	Pancreatic stellate cells contribute to regeneration early after acute necrotising pancreatitis in humans A Zimmermann, B Gloor, A Kappeler, W Uhl, H Friess, and M W Büchler Gut 2002; 51: 574-578. doi:10.1136/gut.51.4.574 [Abstract] [Full text] [PDF] [Request Permissions]
	Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells R Jaster, G Sparmann, J Emmrich, and S Liebe Gut 2002; 51: 579-584. doi:10.1136/gut.51.4.579 [Abstract] [Full text] [PDF] [Request Permissions]

Liver disease

	Histological features and HLA class II alleles in hepatitis C virus chronically infected patients with persistently normal alanine aminotransferase levels C Renou, P Halfon, S Pol, P Cacoub, E Jouve, J P Bronowicki, J P Arpurt, H Rifflet, M Picon, X Causse, V Canva, J Denis, A Tran, M Bourliére, D Ouzan, A Pariente, S Dantin, L Alric, V Cartier, M Reville, and S Caillat-Zucman Gut 2002; 51: 585-590. doi:10.1136/gut.51.4.585 [Abstract] [Full text] [PDF] [Request Permissions]
	Regulation of circulating immune complexes by complement receptor type 1 on erythrocytes in chronic viral liver diseases J Miyaike, Y Iwasaki, A Takahashi, H Shimomura, H Taniguchi, N Koide, K Matsuura, T Ogura, K Tobe, and T Tsuji Gut 2002; 51: 591-596. doi:10.1136/gut.51.4.591 [Abstract] [Full text] [PDF] [Request Permissions]

Case reports

	Fatal hepatitis B reactivation following discontinuation of nucleoside analogues for chronic hepatitis B S G Lim, C T Wai, A Rajnakova, T Kajiji, and R Guan Gut 2002; 51: 597-599. doi:10.1136/gut.51.4.597 [Abstract] [Full text] [PDF] [Request Permissions]

Gut file

	Collagenous colitis with mucosal tears on endoscopic insufflation: a unique presentation M Cruz-Correa, F Milligan, F M Giardiello, T M Bayless, M Torbenson, J H Yardley, Frank W Jackson, and F Wilson Jackson Gut 2002; 51: 600. doi:10.1136/gut.51.4.600 [Extract] [Full text] [PDF] [Request Permissions]

Reviews

	Hepatitis C and HIV-1 coinfection A H Mohsen, P Easterbrook, C B Taylor, and S Norris Gut 2002; 51: 601-608. doi:10.1136/gut.51.4.601 [Abstract] [Full text] [PDF] [Request Permissions]

Letters

	Susceptibility to primary sclerosing cholangitis in Brazil is associated with HLA-DRB1*13 but not with tumour necrosis factor -308 promoter polymorphism P L Bittencourt, S A Palacios, E L R Cançado, F J Carrilho, G Porta, J Kalil, and A C Goldberg Gut 2002; 51: 609-610. doi:10.1136/gut.51.4.609 [Extract] [Full text] [PDF] [Request Permissions]
	Slow transit constipation: more than one disease? C Pehl, T Schmidt, W Schepp, M A Kamm, and A V Emmanuel Gut 2002; 51: 610. doi:10.1136/gut.51.4.610 [Extract] [Full text] [PDF] [Request Permissions]
	Surveillance for hepatocellular carcinoma in liver cirrhosis: have programmes improved because patients have? E Giannini and R Testa Gut 2002; 51: 611. doi:10.1136/gut.51.4.611 [Extract] [Full text] [PDF] [Request Permissions]
	Rectal proliferation and alcohol abuse K Filion, H K Seitz, and C Conradt Gut 2002; 51: 611-612. doi:10.1136/gut.51.4.611-a [Extract] [Full text] [PDF] [Request Permissions]
	Motilin agonists and dyspepsia: throwing out the baby with the bath water M Camilleri, N J Talley, and M Verlinden Gut 2002; 51: 612-613. doi:10.1136/gut.51.4.612 [Extract] [Full text] [PDF] [Request Permissions]
	Reducing dyspepsia costs in the community A Duggan, J Westbrook, and R Valori Gut 2002; 51: 613. doi:10.1136/gut.51.4.613 [Extract] [Full text] [PDF] [Request Permissions]
	Causes of obvious jaundice in South West Wales E H Forrest, J A H Forrest, J G C Kingham, M W Whitehead, and I Hainsworth Gut 2002; 51: 613-614. doi:10.1136/gut.51.4.613-a [Extract] [Full text] [PDF] [Request Permissions]
	Behaviour of Crohn's disease according to the Vienna classification D B Sachar, E Louis, and J Belaiche Gut 2002; 51: 614-615. doi:10.1136/gut.51.4.614 [Extract] [Full text] [PDF] [Request Permissions]

Book reviews

	Pediatric Gastroenterology and Nutrition in Clinical Practice: Edited by C H Lifschitz. New York: Marcel Dekker, 2002, B/W, pp 869. ISBN 0 8247 0510 6 L T Weaver Gut 2002; 51: 615. doi:10.1136/gut.51.4.615 [Extract] [Full text] [PDF] [Request Permissions]
	Gastrointestinal Polyps: Edited by N Haboubi, K Geboes, N Shepherd, et al. Greenwich: Medical Media, 2002, £65.00, colour, pp170. ISBN 1-90015-121-9 P Domizio Gut 2002; 51: 615. doi:10.1136/gut.51.4.615-a [Extract] [Full text] [PDF] [Request Permissions]
	Upper Gastrointestinal Surgery, 2nd Edn: Edited by S M Griffin, S A Raimes. Philadelphia: WB Saunders, 2001, B/W, pp 474. ISBN 0 7020 2587 9 M Winslet Gut 2002; 51: 615-616. doi:10.1136/gut.51.4.615-b [Extract] [Full text] [PDF] [Request Permissions]
	Challenges in Inflammatory Bowel Disease: Edited by D P Jewell, B F Warren, N J Mortensen. Oxford: Blackwell Science, 2001, £59.50, B/W, pp 294. ISBN 0 632 05169 8 D Sachar Gut 2002; 51: 616. doi:10.1136/gut.51.4.616 [Extract] [Full text] [PDF] [Request Permissions]

Corrections

	CORRECTION Gut 2002; 51: 616. doi:10.1136/gut.51.4.616-a [Extract] [Full text] [PDF] [Request Permissions]