Leading articles

	Is intestinal metaplasia of the stomach reversible? M M Walker Gut 2003; 52: 1-4. doi:10.1136/gut.52.1.1 [Abstract] [Full text] [PDF] [Request Permissions]

Digest

	Digest Ian Forgacs Gut 2003; 52: 1. doi:10.1136/gut.52.1.1-a [Extract] [Full text] [PDF] [Request Permissions]

Commentaries

	S, M, L, XL . . . T Wang and G Triadafilopoulos Gut 2003; 52: 5-6. doi:10.1136/gut.52.1.5 [Extract] [Full text] [PDF] [Request Permissions]
	HLA-DQ8 as an Ir gene in coeliac disease K E A Lundin Gut 2003; 52: 7. doi:10.1136/gut.52.1.7 [Abstract] [Full text] [PDF] [Request Permissions]
	A rat virus visits the clinic: translating basic discoveries into clinical medicine in the 21st century C R Boland and A Goel Gut 2003; 52: 8-9. doi:10.1136/gut.52.1.8 [Extract] [Full text] [PDF] [Request Permissions]

Clinical @lert

	Dyspepsia management in the millennium: to test and treat or not? B C Delaney Gut 2003; 52: 10-11. doi:10.1136/gut.52.1.10 [Extract] [Full text] [PDF] [Request Permissions]

Science @lert

	RUNX 3, apoptosis 0: a new gastric tumour suppressor S F Moss Gut 2003; 52: 12-13. doi:10.1136/gut.52.1.12 [Extract] [Full text] [PDF] [Request Permissions]

Debate

	Ablative mucosectomy is the procedure of choice to prevent Barrett’s cancer H Barr Gut 2003; 52: 14-15. doi:10.1136/gut.52.1.14 [Extract] [Full text] [PDF] [Request Permissions]
	Ablative mucosectomy is the procedure of choice to prevent Barrett’s cancer R C Fitzgerald Gut 2003; 52: 16-17. doi:10.1136/gut.52.1.16 [Extract] [Full text] [PDF] [Request Permissions]

Oesophageal disease

	Biopsy surveillance is still necessary in patients with Barrett’s oesophagus despite new endoscopic imaging techniques K Egger, M Werner, A Meining, R Ott, H-D Allescher, H Höfler, M Classen, and T Rösch Gut 2003; 52: 18-23. doi:10.1136/gut.52.1.18 [Abstract] [Full text] [PDF] [Request Permissions]
	Magnification chromoendoscopy for the detection of intestinal metaplasia and dysplasia in Barrett’s oesophagus P Sharma, A P Weston, M Topalovski, R Cherian, A Bhattacharyya, and R E Sampliner Gut 2003; 52: 24-27. doi:10.1136/gut.52.1.24 [Abstract] [Full text] [PDF] [Request Permissions]
	Time gated fluorescence spectroscopy in Barrett’s oesophagus M-A E J Ortner, B Ebert, E Hein, K Zumbusch, D Nolte, U Sukowski, J Weber-Eibel, B Fleige, M Dietel, M Stolte, G Oberhuber, R Porschen, B Klump, H Hörtnagl, H Lochs, and H Rinneberg Gut 2003; 52: 28-33. doi:10.1136/gut.52.1.28 [Abstract] [Full text] [PDF] [Request Permissions]
	Endocinch therapy for gastro-oesophageal reflux disease: a one year prospective follow up Z Mahmood, B P McMahon, Q Arfin, P J Byrne, J V Reynolds, E M Murphy, and D G Weir Gut 2003; 52: 34-39. doi:10.1136/gut.52.1.34 [Abstract] [Full text] [PDF] [Request Permissions]

Helicobacter pylori

	Treatment of Helicobacter pylori in functional dyspepsia resistant to conventional management: a double blind randomised trial with a six month follow up H R Koelz, R Arnold, M Stolte, M Fischer, and A L Blum Gut 2003; 52: 40-46. doi:10.1136/gut.52.1.40 [Abstract] [Full text] [PDF] [Request Permissions]

Small intestine

	Avenin fails to induce a Th1 response in coeliac tissue following in vitro culture C Kilmartin, S Lynch, M Abuzakouk, H Wieser, and C Feighery Gut 2003; 52: 47-52. doi:10.1136/gut.52.1.47 [Abstract] [Full text] [PDF] [Request Permissions]
	Tachykinins potently stimulate human small bowel blood flow: a laser Doppler flowmetry study in humans P T Schmidt, M Lördal, B Gazelius, and P M Hellström Gut 2003; 52: 53-56. doi:10.1136/gut.52.1.53 [Abstract] [Full text] [PDF] [Request Permissions]
	An immunodominant DQ8 restricted gliadin peptide activates small intestinal immune response in in vitro cultured mucosa from HLA-DQ8 positive but not HLA-DQ8 negative coeliac patients G Mazzarella, M Maglio, F Paparo, G Nardone, R Stefanile, L Greco, Y van de Wal, Y Kooy, F Koning, S Auricchio, and R Troncone Gut 2003; 52: 57-62. doi:10.1136/gut.52.1.57 [Abstract] [Full text] [PDF] [Request Permissions]

Therapy update

	Osteoporosis in inflammatory bowel disease J Compston Gut 2003; 52: 63-64. doi:10.1136/gut.52.1.63 [Extract] [Full text] [PDF] [Request Permissions]

Inflammatory bowel disease

	Increased expression of interleukin 17 in inflammatory bowel disease S Fujino, A Andoh, S Bamba, A Ogawa, K Hata, Y Araki, T Bamba, and Y Fujiyama Gut 2003; 52: 65-70. doi:10.1136/gut.52.1.65 [Abstract] [Full text] [PDF] [Request Permissions]
	CARD4/NOD1 is not involved in inflammatory bowel disease H Zouali, S Lesage, F Merlin, J-P Cézard, J-F Colombel, J Belaiche, S Almer, C Tysk, C O’Morain, M Gassull, S Christensen, Y Finkel, R Modigliani, C Gower-Rousseau, J Macry, M Chamaillard, G Thomas, and J-P Hugot Gut 2003; 52: 71-74. doi:10.1136/gut.52.1.71 [Abstract] [Full text] [PDF] [Request Permissions]
	Association between K469E allele of intercellular adhesion molecule 1 gene and inflammatory bowel disease in a Japanese population J Matsuzawa, K Sugimura, Y Matsuda, M Takazoe, K Ishizuka, T Mochizuki, S S Seki, O Yoneyama, H Bannnai, K Suzuki, T Honma, and H Asakura Gut 2003; 52: 75-78. doi:10.1136/gut.52.1.75 [Abstract] [Full text] [PDF] [Request Permissions]
	Induction of experimental ulcerative colitis by Fusobacterium varium isolated from colonic mucosa of patients with ulcerative colitis T Ohkusa, I Okayasu, T Ogihara, K Morita, M Ogawa, and N Sato Gut 2003; 52: 79-83. doi:10.1136/gut.52.1.79 [Abstract] [Full text] [PDF] [Request Permissions]
	Changes in chemical coding of myenteric neurones in ulcerative colitis M Neunlist, P Aubert, C Toquet, T Oreshkova, J Barouk, P A Lehur, M Schemann, and J P Galmiche Gut 2003; 52: 84-90. doi:10.1136/gut.52.1.84 [Abstract] [Full text] [PDF] [Request Permissions]
	Interleukin 10 genotypes in irritable bowel syndrome: evidence for an inflammatory component? W M Gonsalkorale, C Perrey, V Pravica, P J Whorwell, and I V Hutchinson Gut 2003; 52: 91-93. doi:10.1136/gut.52.1.91 [Abstract] [Full text] [PDF] [Request Permissions]

Cancer

	Butyrate induced Caco-2 cell apoptosis is mediated via the mitochondrial pathway F M Ruemmele, S Schwartz, E G Seidman, S Dionne, E Levy, and M J Lentze Gut 2003; 52: 94-100. doi:10.1136/gut.52.1.94 [Abstract] [Full text] [PDF] [Request Permissions]
	A prospective study of circulating mutant KRAS2 in the serum of patients with colorectal neoplasia: strong prognostic indicator in postoperative follow up B M Ryan, F Lefort, R McManus, J Daly, P W N Keeling, D G Weir, and D Kelleher Gut 2003; 52: 101-108. doi:10.1136/gut.52.1.101 [Abstract] [Full text] [PDF] [Request Permissions]

Biliary disease

	Gall bladder dysmotility: a risk factor for gall stone formation in hypertriglyceridaemia and reversal on triglyceride lowering therapy by bezafibrate and fish oil I J A M Jonkers, A H M Smelt, M Ledeboer, M E Hollum, I Biemond, F Kuipers, F Stellaard, R Boverhof, A E Meinders, C H B W Lamers, and A A M Masclee Gut 2003; 52: 109-115. doi:10.1136/gut.52.1.109 [Abstract] [Full text] [PDF] [Request Permissions]
	Risk factors for recurrent bile duct stones after endoscopic papillotomy T Ando, T Tsuyuguchi, T Okugawa, M Saito, T Ishihara, T Yamaguchi, and H Saisho Gut 2003; 52: 116-121. doi:10.1136/gut.52.1.116 [Abstract] [Full text] [PDF] [Request Permissions]

Liver disease

	Different hepatitis B virus core gene mutations in children with chronic infection and hepatocellular carcinoma Y-H Ni, M-H Chang, H-Y Hsu, and D-J Tsuei Gut 2003; 52: 122-125. doi:10.1136/gut.52.1.122 [Abstract] [Full text] [PDF] [Request Permissions]
	Impact of smoking on histological liver lesions in chronic hepatitis C C Hézode, I Lonjon, F Roudot-Thoraval, J-P Mavier, J-M Pawlotsky, E S Zafrani, and D Dhumeaux Gut 2003; 52: 126-129. doi:10.1136/gut.52.1.126 [Abstract] [Full text] [PDF] [Request Permissions]
	Acute propranolol administration effectively decreases portal pressure in patients with TIPS dysfunction L Bellis, E Moitinho, J G Abraldes, M Graupera, J C García-Pagán, J Rodés, and J Bosch Gut 2003; 52: 130-133. doi:10.1136/gut.52.1.130 [Abstract] [Full text] [PDF] [Request Permissions]
	MELD scoring system is useful for predicting prognosis in patients with liver cirrhosis and is correlated with residual liver function: a European study F Botta, E Giannini, P Romagnoli, A Fasoli, F Malfatti, B Chiarbonello, E Testa, D Risso, G Colla, and R Testa Gut 2003; 52: 134-139. doi:10.1136/gut.52.1.134 [Abstract] [Full text] [PDF] [Request Permissions]

Case reports

	Safe treatment of thiopurine S-methyltransferase deficient Crohn’s disease patients with azathioprine B A Kaskas, E Louis, U Hindorf, E Schaeffeler, J Deflandre, F Graepler, K Schmiegelow, M Gregor, U M Zanger, M Eichelbaum, and M Schwab Gut 2003; 52: 140-142. doi:10.1136/gut.52.1.140 [Abstract] [Full text] [PDF] [Request Permissions]

Gut file

	Elemental diet in the treatment of orofacial Crohn's disease E A B Cameron and S J Middleton Gut 2003; 52: 143. doi:10.1136/gut.52.1.143 [Extract] [Full text] [PDF] [Request Permissions]

Reviews

	Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets D W Hommes, M P Peppelenbosch, and S J H van Deventer Gut 2003; 52: 144-151. doi:10.1136/gut.52.1.144 [Abstract] [Full text] [PDF] [Request Permissions]

Letters

	Living related liver transplantation: a Japanese experience and development of a checklist for donors' informed consent A Akabayashi, M Nishimori, M Fujita, and B T Slingsby Gut 2003; 52: 152. doi:10.1136/gut.52.1.152 [Extract] [Full text] [PDF] [Request Permissions]
	Endoscopic surveillance of premalignant gastric lesions S Sebastian, J Seery, C O’Morain, and M Buckley Gut 2003; 52: 152-153. doi:10.1136/gut.52.1.152-a [Extract] [Full text] [PDF] [Request Permissions]
	Smoking and ulcer healing A Duggan and N Rutherford Gut 2003; 52: 153. doi:10.1136/gut.52.1.153 [Extract] [Full text] [PDF] [Request Permissions]
	Oesophageal pH monitoring in Barrett's oesophagus C S Neumann, B T Cooper, and R Fass Gut 2003; 52: 153. doi:10.1136/gut.52.1.153-a [Extract] [Full text] [PDF] [Request Permissions]
	Influence of clinical factors, drug use, and food intake on the glutathione system H Shirin, J T Pinto, S F Moss, H Hoensch, and I Morgenstern Gut 2003; 52: 154. doi:10.1136/gut.52.1.154 [Extract] [Full text] [PDF] [Request Permissions]
	Mycobacterium avium subspecies paratuberculosis as a cause of Crohn’s disease D S Grimes Gut 2003; 52: 155. doi:10.1136/gut.52.1.155 [Extract] [Full text] [PDF] [Request Permissions]

Book reviews

	Modern Management of Cancer of the Rectum: Edited by R A Audisio, J G Geraghty, W E Longo. Berlin: Springer-Verlag, 2001, B/W, pp 234. ISBN 1-85233-287-5. R J Heald Gut 2003; 52: 156. doi:10.1136/gut.52.1.156 [Extract] [Full text] [PDF] [Request Permissions]
	Management of Chronic Viral Hepatitis: Edited by S C Gordon. New York: Marcel Dekker, 2002, B/W, pp 380. ISBN 08247-0582-3 M Cramp Gut 2003; 52: 156. doi:10.1136/gut.52.1.156-a [Extract] [Full text] [PDF] [Request Permissions]
	Abdominal Ultrasound: M Stocksley. Greenwich Medical Media, 2001, £35.00, B/W, pp 286. ISBN 1-90015-166-9 N Power Gut 2003; 52: 156-157. doi:10.1136/gut.52.1.156-b [Extract] [Full text] [PDF] [Request Permissions]

Corrections

	CORRECTION Gut 2003; 52: 157. doi:10.1136/gut.52.1.157 [Extract] [Full text] [PDF] [Request Permissions]