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October 2003 (Volume 52, Number 10). [Index by author]

	(Cover illustration)	Commentaries Digest Oesophagus Stomach Small intestine Inflammation and inflammatory bowel disease Colon Pancreas Liver Case reports Reviews Letters

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Commentaries

Nutritional therapy for cancer cachexia
R F Grimble
Gut 2003; 52: 1391-1392. doi:10.1136/gut.52.10.1391 [Extract] [Full text] [PDF] [Request Permissions]

Origins of cardiac dysfunction in cirrhosis
W Jiménez and V Arroyo
Gut 2003; 52: 1392-1394. doi:10.1136/gut.52.10.1392 [Extract] [Full text] [PDF] [Request Permissions]

Transplanting the genetic susceptibility to Crohn’s disease
M H Holtmann and M F Neurath
Gut 2003; 52: 1394-1396. doi:10.1136/gut.52.10.1394 [Extract] [Full text] [PDF] [Request Permissions]

Digest

Digest
Robin Spiller
Gut 2003; 52: 1391. doi:10.1136/gut.52.10.1391-a [Extract] [Full text] [PDF] [Request Permissions]

Oesophagus

Effect of the GABA_B agonist baclofen in patients with symptoms and duodeno-gastro-oesophageal reflux refractory to proton pump inhibitors
G H Koek, D Sifrim, T Lerut, J Janssens, and J Tack
Gut 2003; 52: 1397-1402. doi:10.1136/gut.52.10.1397 [Abstract] [Full text] [PDF] [Request Permissions]

Stomach

Effect of scheduled second therapeutic endoscopy on peptic ulcer rebleeding: a prospective randomised trial
P W Y Chiu, C Y W Lam, S W Lee, K H Kwong, S H Lam, D T Y Lee, and S P Y Kwok
Gut 2003; 52: 1403-1407. doi:10.1136/gut.52.10.1403 [Abstract] [Full text] [PDF] [Request Permissions]

Helicobacter pylori upregulates matrilysin (MMP-7) in epithelial cells in vivo and in vitro in a Cag dependent manner
J R Bebb, D P Letley, R J Thomas, F Aviles, H M Collins, S A Watson, N M Hand, A Zaitoun, and J C Atherton
Gut 2003; 52: 1408-1413. doi:10.1136/gut.52.10.1408 [Abstract] [Full text] [PDF] [Request Permissions]

Role of cognitive factors in symptom induction following high and low fat meals in patients with functional dyspepsia
C Feinle-Bisset, B Meier, and M Fried
Gut 2003; 52: 1414-1418. doi:10.1136/gut.52.10.1414 [Abstract] [Full text] [PDF] [Request Permissions]

Small intestine

Efficacy and tolerability of racecadotril in the treatment of cholera in adults: a double blind, randomised, controlled clinical trial
N H Alam, H Ashraf, W A Khan, M M Karim, and G J Fuchs
Gut 2003; 52: 1419-1423. doi:10.1136/gut.52.10.1419 [Abstract] [Full text] [PDF] [Request Permissions]

Scavenger receptor class B type I (SR-BI) in pig enterocytes: trafficking from the brush border to lipid droplets during fat absorption
G H Hansen, L-L Niels-Christiansen, L Immerdal, and E M Danielsen
Gut 2003; 52: 1424-1431. doi:10.1136/gut.52.10.1424 [Abstract] [Full text] [PDF] [Request Permissions]

Inflammation and inflammatory bowel disease

Changing pattern of paediatric inflammatory bowel disease in northern Stockholm 1990–2001
H Hildebrand, Y Finkel, L Grahnquist, J Lindholm, A Ekbom, and J Askling
Gut 2003; 52: 1432-1434. doi:10.1136/gut.52.10.1432 [Abstract] [Full text] [PDF] [Request Permissions]

Activated platelets are the source of elevated levels of soluble CD40 ligand in the circulation of inflammatory bowel disease patients
S Danese, J A Katz, S Saibeni, A Papa, A Gasbarrini, M Vecchi, and C Fiocchi
Gut 2003; 52: 1435-1441. doi:10.1136/gut.52.10.1435 [Abstract] [Full text] [PDF] [Request Permissions]

Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E₁ and E₂ production by intestinal myofibroblasts
L E M Willemsen, M A Koetsier, S J H van Deventer, and E A F van Tol
Gut 2003; 52: 1442-1447. doi:10.1136/gut.52.10.1442 [Abstract] [Full text] [PDF] [Request Permissions]

Inducible CD40 expression mediates NF ${kappa}$ B activation and cytokine secretion in human colonic fibroblasts
C M Gelbmann, S N Leeb, D Vogl, M Maendel, H Herfarth, J Schölmerich, W Falk, and G Rogler
Gut 2003; 52: 1448-1456. doi:10.1136/gut.52.10.1448 [Abstract] [Full text] [PDF] [Request Permissions]

Neutral endopeptidase (EC 3.4.24.11) downregulates the onset of intestinal inflammation in the nematode infected mouse
G Barbara, R De Giorgio, V Stanghellini, R Corinaldesi, C Cremon, N Gerard, C Gerard, E F Grady, N W Bunnett, P A Blennerhassett, and S M Collins
Gut 2003; 52: 1457-1464. doi:10.1136/gut.52.10.1457 [Abstract] [Full text] [PDF] [Request Permissions]

Colon

The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development
C Bonhomme, I Duluc, E Martin, K Chawengsaksophak, M-P Chenard, M Kedinger, F Beck, J-N Freund, and C Domon-Dell
Gut 2003; 52: 1465-1471. doi:10.1136/gut.52.10.1465 [Abstract] [Full text] [PDF] [Request Permissions]

Phosphatidylinositol 3-kinase mediates proliferative signals in intestinal epithelial cells
H Sheng, J Shao, C M Townsend, jr, and B M Evers
Gut 2003; 52: 1472-1478. doi:10.1136/gut.52.10.1472 [Abstract] [Full text] [PDF] [Request Permissions]

Effect of a protein and energy dense n-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial
K C H Fearon, M F von Meyenfeldt, A G W Moses, R van Geenen, A Roy, D J Gouma, A Giacosa, A Van Gossum, J Bauer, M D Barber, N K Aaronson, A C Voss, and M J Tisdale
Gut 2003; 52: 1479-1486. doi:10.1136/gut.52.10.1479 [Abstract] [Full text] [PDF] [Request Permissions]

Pancreas

Activin A is an autocrine activator of rat pancreatic stellate cells: potential therapeutic role of follistatin for pancreatic fibrosis
N Ohnishi, T Miyata, H Ohnishi, H Yasuda, K Tamada, N Ueda, H Mashima, and K Sugano
Gut 2003; 52: 1487-1493. doi:10.1136/gut.52.10.1487 [Abstract] [Full text] [PDF] [Request Permissions]

Liver

Mutations in SRD5B1 (AKR1D1), the gene encoding ${Delta}$ ⁴-3-oxosteroid 5ß-reductase, in hepatitis and liver failure in infancy
H A Lemonde, E J Custard, J Bouquet, M Duran, H Overmars, P J Scambler, and P T Clayton
Gut 2003; 52: 1494-1499. doi:10.1136/gut.52.10.1494 [Abstract] [Full text] [PDF] [Request Permissions]

Evaluation of a prison outreach clinic for the diagnosis and prevention of hepatitis C: implications for the national strategy
C Skipper, J M Guy, J Parkes, P Roderick, and W M Rosenberg
Gut 2003; 52: 1500-1504. doi:10.1136/gut.52.10.1500 [Abstract] [Full text] [PDF] [Request Permissions]

Evidence for altered vascular responses to exogenous endothelin-1 in patients with advanced cirrhosis with restoration of the normal vasoconstrictor response following successful liver transplantation
R B Vaughan, P W Angus, and J P F Chin-Dusting
Gut 2003; 52: 1505-1510. doi:10.1136/gut.52.10.1505 [Abstract] [Full text] [PDF] [Request Permissions]

Increased circulating pro-brain natriuretic peptide (proBNP) and brain natriuretic peptide (BNP) in patients with cirrhosis: relation to cardiovascular dysfunction and severity of disease
J H Henriksen, J P Gøtze, S Fuglsang, E Christensen, F Bendtsen, and S Møller
Gut 2003; 52: 1511-1517. doi:10.1136/gut.52.10.1511 [Abstract] [Full text] [PDF] [Request Permissions]

Case reports

Fulminant Crohn’s colitis after allogeneic stem cell transplantation
S A Sonwalkar, R M James, T Ahmad, L Zhang, C S Verbeke, D L Barnard, D P Jewell, and M A Hull
Gut 2003; 52: 1518-1521. doi:10.1136/gut.52.10.1518 [Abstract] [Full text] [PDF] [Request Permissions]

Reviews

The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria
A J Stagg, A L Hart, S C Knight, and M A Kamm
Gut 2003; 52: 1522-1529. doi:10.1136/gut.52.10.1522 [Abstract] [Full text] [PDF] [Request Permissions]

Letters

Sulphasalazine and mesalazine: serious adverse reactions re-evaluated on the basis of suspected adverse reaction reports to the Committee on Safety of Medicines • Author’s reply
R F Logan, T P van Staa, M J S Langman, and R A J Ransford
Gut 2003; 52: 1530-1531. doi:10.1136/gut.52.10.1530 [Extract] [Full text] [PDF] [Request Permissions]

Worsening of steatosis and fibrosis progression in hepatitis C
L Castéra, J-M Pawlotsky, and D Dhumeaux
Gut 2003; 52: 1531. doi:10.1136/gut.52.10.1531 [Extract] [Full text] [PDF] [Request Permissions]

Complete regression of advanced HCC with long acting octreotide
J T Siveke, C Folwaczny, and C Herberhold
Gut 2003; 52: 1531. doi:10.1136/gut.52.10.1531-a [Extract] [Full text] [PDF] [Request Permissions]

Diagnosing small bowel Crohn’s disease with wireless capsule endoscopy • Authors’ reply
K Schulmann, S Hollerbach, W Schmiegel, Z Fireman, and Y Kopelman
Gut 2003; 52: 1531-1532. doi:10.1136/gut.52.10.1531-b [Extract] [Full text] [PDF] [Request Permissions]

Cost effectiveness of pegylated interferon alpha 2b and ribavirin combination in chronic hepatitis C
T Poynard
Gut 2003; 52: 1532. doi:10.1136/gut.52.10.1532 [Extract] [Full text] [PDF] [Request Permissions]

Risk of fracture in coeliac disease
R Logan and J West
Gut 2003; 52: 1532. doi:10.1136/gut.52.10.1532-a [Extract] [Full text] [PDF] [Request Permissions]

Cover

Antral biopsy stained for MMP-7 in an H pylori infected patient (from the paper by Bebb et al, pp 1408-13).

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	Nutritional therapy for cancer cachexia R F Grimble Gut 2003; 52: 1391-1392. doi:10.1136/gut.52.10.1391 [Extract] [Full text] [PDF] [Request Permissions]

	Origins of cardiac dysfunction in cirrhosis W Jiménez and V Arroyo Gut 2003; 52: 1392-1394. doi:10.1136/gut.52.10.1392 [Extract] [Full text] [PDF] [Request Permissions]

	Transplanting the genetic susceptibility to Crohn’s disease M H Holtmann and M F Neurath Gut 2003; 52: 1394-1396. doi:10.1136/gut.52.10.1394 [Extract] [Full text] [PDF] [Request Permissions]

	Digest Robin Spiller Gut 2003; 52: 1391. doi:10.1136/gut.52.10.1391-a [Extract] [Full text] [PDF] [Request Permissions]

	Effect of the GABA_B agonist baclofen in patients with symptoms and duodeno-gastro-oesophageal reflux refractory to proton pump inhibitors G H Koek, D Sifrim, T Lerut, J Janssens, and J Tack Gut 2003; 52: 1397-1402. doi:10.1136/gut.52.10.1397 [Abstract] [Full text] [PDF] [Request Permissions]

	Effect of scheduled second therapeutic endoscopy on peptic ulcer rebleeding: a prospective randomised trial P W Y Chiu, C Y W Lam, S W Lee, K H Kwong, S H Lam, D T Y Lee, and S P Y Kwok Gut 2003; 52: 1403-1407. doi:10.1136/gut.52.10.1403 [Abstract] [Full text] [PDF] [Request Permissions]

	Helicobacter pylori upregulates matrilysin (MMP-7) in epithelial cells in vivo and in vitro in a Cag dependent manner J R Bebb, D P Letley, R J Thomas, F Aviles, H M Collins, S A Watson, N M Hand, A Zaitoun, and J C Atherton Gut 2003; 52: 1408-1413. doi:10.1136/gut.52.10.1408 [Abstract] [Full text] [PDF] [Request Permissions]

	Role of cognitive factors in symptom induction following high and low fat meals in patients with functional dyspepsia C Feinle-Bisset, B Meier, and M Fried Gut 2003; 52: 1414-1418. doi:10.1136/gut.52.10.1414 [Abstract] [Full text] [PDF] [Request Permissions]

	Efficacy and tolerability of racecadotril in the treatment of cholera in adults: a double blind, randomised, controlled clinical trial N H Alam, H Ashraf, W A Khan, M M Karim, and G J Fuchs Gut 2003; 52: 1419-1423. doi:10.1136/gut.52.10.1419 [Abstract] [Full text] [PDF] [Request Permissions]

	Scavenger receptor class B type I (SR-BI) in pig enterocytes: trafficking from the brush border to lipid droplets during fat absorption G H Hansen, L-L Niels-Christiansen, L Immerdal, and E M Danielsen Gut 2003; 52: 1424-1431. doi:10.1136/gut.52.10.1424 [Abstract] [Full text] [PDF] [Request Permissions]

	Changing pattern of paediatric inflammatory bowel disease in northern Stockholm 1990–2001 H Hildebrand, Y Finkel, L Grahnquist, J Lindholm, A Ekbom, and J Askling Gut 2003; 52: 1432-1434. doi:10.1136/gut.52.10.1432 [Abstract] [Full text] [PDF] [Request Permissions]

	Activated platelets are the source of elevated levels of soluble CD40 ligand in the circulation of inflammatory bowel disease patients S Danese, J A Katz, S Saibeni, A Papa, A Gasbarrini, M Vecchi, and C Fiocchi Gut 2003; 52: 1435-1441. doi:10.1136/gut.52.10.1435 [Abstract] [Full text] [PDF] [Request Permissions]

	Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E₁ and E₂ production by intestinal myofibroblasts L E M Willemsen, M A Koetsier, S J H van Deventer, and E A F van Tol Gut 2003; 52: 1442-1447. doi:10.1136/gut.52.10.1442 [Abstract] [Full text] [PDF] [Request Permissions]

	Inducible CD40 expression mediates NF ${kappa}$ B activation and cytokine secretion in human colonic fibroblasts C M Gelbmann, S N Leeb, D Vogl, M Maendel, H Herfarth, J Schölmerich, W Falk, and G Rogler Gut 2003; 52: 1448-1456. doi:10.1136/gut.52.10.1448 [Abstract] [Full text] [PDF] [Request Permissions]

	Neutral endopeptidase (EC 3.4.24.11) downregulates the onset of intestinal inflammation in the nematode infected mouse G Barbara, R De Giorgio, V Stanghellini, R Corinaldesi, C Cremon, N Gerard, C Gerard, E F Grady, N W Bunnett, P A Blennerhassett, and S M Collins Gut 2003; 52: 1457-1464. doi:10.1136/gut.52.10.1457 [Abstract] [Full text] [PDF] [Request Permissions]

	*The Cdx2* homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development** C Bonhomme, I Duluc, E Martin, K Chawengsaksophak, M-P Chenard, M Kedinger, F Beck, J-N Freund, and C Domon-Dell Gut 2003; 52: 1465-1471. doi:10.1136/gut.52.10.1465 [Abstract] [Full text] [PDF] [Request Permissions]

	Phosphatidylinositol 3-kinase mediates proliferative signals in intestinal epithelial cells H Sheng, J Shao, C M Townsend, jr, and B M Evers Gut 2003; 52: 1472-1478. doi:10.1136/gut.52.10.1472 [Abstract] [Full text] [PDF] [Request Permissions]

	Effect of a protein and energy dense n-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial K C H Fearon, M F von Meyenfeldt, A G W Moses, R van Geenen, A Roy, D J Gouma, A Giacosa, A Van Gossum, J Bauer, M D Barber, N K Aaronson, A C Voss, and M J Tisdale Gut 2003; 52: 1479-1486. doi:10.1136/gut.52.10.1479 [Abstract] [Full text] [PDF] [Request Permissions]

	Activin A is an autocrine activator of rat pancreatic stellate cells: potential therapeutic role of follistatin for pancreatic fibrosis N Ohnishi, T Miyata, H Ohnishi, H Yasuda, K Tamada, N Ueda, H Mashima, and K Sugano Gut 2003; 52: 1487-1493. doi:10.1136/gut.52.10.1487 [Abstract] [Full text] [PDF] [Request Permissions]

	*Mutations in SRD5B1* (AKR1D1), the gene encoding ${Delta}$ ⁴-3-oxosteroid 5ß-reductase, in hepatitis and liver failure in infancy** H A Lemonde, E J Custard, J Bouquet, M Duran, H Overmars, P J Scambler, and P T Clayton Gut 2003; 52: 1494-1499. doi:10.1136/gut.52.10.1494 [Abstract] [Full text] [PDF] [Request Permissions]

	Evaluation of a prison outreach clinic for the diagnosis and prevention of hepatitis C: implications for the national strategy C Skipper, J M Guy, J Parkes, P Roderick, and W M Rosenberg Gut 2003; 52: 1500-1504. doi:10.1136/gut.52.10.1500 [Abstract] [Full text] [PDF] [Request Permissions]

	Evidence for altered vascular responses to exogenous endothelin-1 in patients with advanced cirrhosis with restoration of the normal vasoconstrictor response following successful liver transplantation R B Vaughan, P W Angus, and J P F Chin-Dusting Gut 2003; 52: 1505-1510. doi:10.1136/gut.52.10.1505 [Abstract] [Full text] [PDF] [Request Permissions]

	Increased circulating pro-brain natriuretic peptide (proBNP) and brain natriuretic peptide (BNP) in patients with cirrhosis: relation to cardiovascular dysfunction and severity of disease J H Henriksen, J P Gøtze, S Fuglsang, E Christensen, F Bendtsen, and S Møller Gut 2003; 52: 1511-1517. doi:10.1136/gut.52.10.1511 [Abstract] [Full text] [PDF] [Request Permissions]

	Fulminant Crohn’s colitis after allogeneic stem cell transplantation S A Sonwalkar, R M James, T Ahmad, L Zhang, C S Verbeke, D L Barnard, D P Jewell, and M A Hull Gut 2003; 52: 1518-1521. doi:10.1136/gut.52.10.1518 [Abstract] [Full text] [PDF] [Request Permissions]

	The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria A J Stagg, A L Hart, S C Knight, and M A Kamm Gut 2003; 52: 1522-1529. doi:10.1136/gut.52.10.1522 [Abstract] [Full text] [PDF] [Request Permissions]

	Sulphasalazine and mesalazine: serious adverse reactions re-evaluated on the basis of suspected adverse reaction reports to the Committee on Safety of Medicines • Author’s reply R F Logan, T P van Staa, M J S Langman, and R A J Ransford Gut 2003; 52: 1530-1531. doi:10.1136/gut.52.10.1530 [Extract] [Full text] [PDF] [Request Permissions]

	Worsening of steatosis and fibrosis progression in hepatitis C L Castéra, J-M Pawlotsky, and D Dhumeaux Gut 2003; 52: 1531. doi:10.1136/gut.52.10.1531 [Extract] [Full text] [PDF] [Request Permissions]

	Complete regression of advanced HCC with long acting octreotide J T Siveke, C Folwaczny, and C Herberhold Gut 2003; 52: 1531. doi:10.1136/gut.52.10.1531-a [Extract] [Full text] [PDF] [Request Permissions]

	Diagnosing small bowel Crohn’s disease with wireless capsule endoscopy • Authors’ reply K Schulmann, S Hollerbach, W Schmiegel, Z Fireman, and Y Kopelman Gut 2003; 52: 1531-1532. doi:10.1136/gut.52.10.1531-b [Extract] [Full text] [PDF] [Request Permissions]

	Cost effectiveness of pegylated interferon alpha 2b and ribavirin combination in chronic hepatitis C T Poynard Gut 2003; 52: 1532. doi:10.1136/gut.52.10.1532 [Extract] [Full text] [PDF] [Request Permissions]

	Risk of fracture in coeliac disease R Logan and J West Gut 2003; 52: 1532. doi:10.1136/gut.52.10.1532-a [Extract] [Full text] [PDF] [Request Permissions]