Leading articles

	Advances in our understanding of the pathology of chronic intestinal pseudo-obstruction R De Giorgio, G Sarnelli, R Corinaldesi, and V Stanghellini Gut 2004; 53: 1549-1552. doi:10.1136/gut.2004.043968 [Abstract] [Full text] [PDF] [Request Permissions]

Digest

	Digest Robin Spiller Gut 2004; 53: 1549. [Extract] [Full text] [PDF] [Request Permissions]

Miscellanea

	Unusual complication of tuberous sclerosis complex D Chatelain, H Sevestre, H Zaher, M Flamant, F Brazier, G Geslin, J-L Dupas, and J-M Regimbeau Gut 2004; 53: 1552. doi:10.1136/gut.2003.037713 [Extract] [Full text] [PDF] [Request Permissions]
	Answer Gut 2004; 53: 1565. [Extract] [Full text] [PDF] [Request Permissions]
	A phenomenal response to treatment by an advanced tumour S H Rahman, A Roy, M Leahy, P J Guillou, and G J Toogood Gut 2004; 53: 1582. doi:10.1136/gut.2003.029611 [Extract] [Full text] [PDF] [Request Permissions]
	Bamboo trees in the stomach A Hokama, F Kinjo, R Tomiyama, T Makishi, K Kobashigawa, T Sunagawa, Y Yonamine, Y Kugai, R Matayoshi, and A Saito Gut 2004; 53: 1589. doi:10.1136/gut.2003.038323 [Extract] [Full text] [PDF] [Request Permissions]
	Answer Gut 2004; 53: 1616. [Extract] [Full text] [PDF] [Request Permissions]
	Answer Gut 2004; 53: 1631. [Extract] [Full text] [PDF] [Request Permissions]
	An important pitfall in diagnosing gall bladder cancer J Feisthammel, K Caca, J Mössner, T Kahn, and R Kluge Gut 2004; 53: 1651. doi:10.1136/gut.2003.036947 [Extract] [Full text] [PDF] [Request Permissions]
	Answer Gut 2004; 53: 1664. [Extract] [Full text] [PDF] [Request Permissions]

Commentaries

	Importance of anti- and pro-nociceptive mechanisms in human disease I Tracey and P Dunckley Gut 2004; 53: 1553-1555. doi:10.1136/gut.2004.046110 [Extract] [Full text] [PDF] [Request Permissions]
	T cell apoptosis and inflammatory bowel disease M P Peppelenbosch and S J H van Deventer Gut 2004; 53: 1556-1558. doi:10.1136/gut.2004.040824 [Extract] [Full text] [PDF] [Request Permissions]
	NOD2 mutations and Crohn’s disease: are Paneth cells and their antimicrobial peptides the link? M C Grimm and P Pavli Gut 2004; 53: 1558-1560. doi:10.1136/gut.2004.043307 [Extract] [Full text] [PDF] [Request Permissions]

Oesophagus

	Aerophagia, gastric, and supragastric belching: a study using intraluminal electrical impedance monitoring A J Bredenoord, B L A M Weusten, D Sifrim, R Timmer, and A J P M Smout Gut 2004; 53: 1561-1565. doi:10.1136/gut.2004.042945 [Abstract] [Full text] [PDF] [Request Permissions]

Stomach

	Cannabinoid hyperemesis: cyclical hyperemesis in association with chronic cannabis abuse J H Allen, G M de Moore, R Heddle, and J C Twartz Gut 2004; 53: 1566-1570. doi:10.1136/gut.2003.036350 [Abstract] [Full text] [PDF] [Request Permissions]

Small intestine

	A genetic test which can be used to diagnose adult-type hypolactasia in children H Rasinperä, E Savilahti, N S Enattah, M Kuokkanen, N Tötterman, H Lindahl, I Järvelä, and K-L Kolho Gut 2004; 53: 1571-1576. doi:10.1136/gut.2004.040048 [Abstract] [Full text] [PDF] [Request Permissions]

Gut motility

	Inhibitory actions of a high fibre diet on intestinal gas transit in healthy volunteers S Gonlachanvit, R Coleski, C Owyang, and WL Hasler Gut 2004; 53: 1577-1582. doi:10.1136/gut.2004.041632 [Abstract] [Full text] [PDF] [Request Permissions]
	Deranged smooth muscle -actin as a biomarker of intestinal pseudo-obstruction: a controlled multinational case series C H Knowles, D B A Silk, A Darzi, B Veress, R Feakins, A H Raimundo, T Crompton, E C Browning, G Lindberg, and J E Martin Gut 2004; 53: 1583-1589. doi:10.1136/gut.2003.037275 [Abstract] [Full text] [PDF] [Request Permissions]
	PEG 3350 (Transipeg) versus lactulose in the treatment of childhood functional constipation: a double blind, randomised, controlled, multicentre trial W Voskuijl, F de Lorijn, W Verwijs, P Hogeman, J Heijmans, W Mäkel, J Taminiau, and M Benninga Gut 2004; 53: 1590-1594. doi:10.1136/gut.2004.043620 [Abstract] [Full text] [PDF] [Request Permissions]

Irritable bowel syndrome

	Brain functional magnetic resonance imaging of rectal pain and activation of endogenous inhibitory mechanisms in irritable bowel syndrome patient subgroups and healthy controls C H Wilder-Smith, D Schindler, K Lovblad, S M Redmond, and A Nirkko Gut 2004; 53: 1595-1601. doi:10.1136/gut.2003.028514 [Abstract] [Full text] [PDF] [Request Permissions]

Probiotics

	Modulation of human dendritic cell phenotype and function by probiotic bacteria A L Hart, K Lammers, P Brigidi, B Vitali, F Rizzello, P Gionchetti, M Campieri, M A Kamm, S C Knight, and A J Stagg Gut 2004; 53: 1602-1609. doi:10.1136/gut.2003.037325 [Abstract] [Full text] [PDF] [Request Permissions]
	Prebiotic carbohydrates modify the mucosa associated microflora of the human large bowel S J Langlands, M J Hopkins, N Coleman, and J H Cummings Gut 2004; 53: 1610-1616. doi:10.1136/gut.2003.037580 [Abstract] [Full text] [PDF] [Request Permissions]
	Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine W Kruis, P Fric, J Pokrotnieks, M Lukás, B Fixa, M Kascák, M A Kamm, J Weismueller, C Beglinger, M Stolte, C Wolff, and J Schulze Gut 2004; 53: 1617-1623. doi:10.1136/gut.2003.037747 [Abstract] [Full text] [PDF] [Request Permissions]

Inflammatory bowel disease

	Divergent cell cycle kinetics underlie the distinct functional capacity of mucosal T cells in Crohn’s disease and ulcerative colitis A Sturm, A Z A Leite, S Danese, K A Krivacic, G A West, S Mohr, J W Jacobberger, and C Fiocchi Gut 2004; 53: 1624-1631. doi:10.1136/gut.2003.033613 [Abstract] [Full text] [PDF] [Request Permissions]
	Induction of T lymphocyte apoptosis by sulphasalazine in patients with Crohn’s disease J Doering, B Begue, M J Lentze, F Rieux-Laucat, O Goulet, J Schmitz, N Cerf-Bensussan, and F M Ruemmele Gut 2004; 53: 1632-1638. doi:10.1136/gut.2003.037911 [Abstract] [Full text] [PDF] [Request Permissions]
	A randomised controlled trial to assess the effectiveness and cost of a patient orientated self management approach to chronic inflammatory bowel disease A P Kennedy, E Nelson, D Reeves, G Richardson, C Roberts, A Robinson, A E Rogers, M Sculpher, D G Thompson the North-West Regional Gastrointestinal Research Group Gut 2004; 53: 1639-1645. doi:10.1136/gut.2003.034256 [Abstract] [Full text] [PDF] [Request Permissions]
	A randomised, controlled, double blind, escalating dose study of alicaforsen enema in active ulcerative colitis S J H van Deventer, J A Tami, M K Wedel European Colitis Study Group Gut 2004; 53: 1646-1651. doi:10.1136/gut.2003.036160 [Abstract] [Full text] [PDF] [Request Permissions]
	Oral contrast enhanced bowel ultrasonography in the assessment of small intestine Crohn’s disease. A prospective comparison with conventional ultrasound, x ray studies, and ileocolonoscopy F Parente, S Greco, M Molteni, A Anderloni, G M Sampietro, P G Danelli, R Bianco, S Gallus, and G Bianchi Porro Gut 2004; 53: 1652-1657. doi:10.1136/gut.2004.041038 [Abstract] [Full text] [PDF] [Request Permissions]
	NOD2 (CARD15) mutations in Crohn’s disease are associated with diminished mucosal -defensin expression J Wehkamp, J Harder, M Weichenthal, M Schwab, E Schäffeler, M Schlee, K R Herrlinger, A Stallmach, F Noack, P Fritz, J M Schröder, C L Bevins, K Fellermann, and E F Stange Gut 2004; 53: 1658-1664. doi:10.1136/gut.2003.032805 [Abstract] [Full text] [PDF] [Request Permissions]

Liver

	Increased intrahepatic cyclooxygenase 2, matrix metalloproteinase 2, and matrix metalloproteinase 9 expression is associated with progressive liver disease in chronic hepatitis C virus infection: role of viral core and NS5A proteins O Núñez, A Fernández-Martínez, P L Majano, A Apolinario, M Gómez-Gonzalo, I Benedicto, M López-Cabrera, L Boscá, G Clemente, C García-Monzón, and P Martín-Sanz Gut 2004; 53: 1665-1672. doi:10.1136/gut.2003.038364 [Abstract] [Full text] [PDF] [Request Permissions]
	Multispecific T cell response and negative HCV RNA tests during acute HCV infection are early prognostic factors of spontaneous clearance E Spada, A Mele, A Berton, L Ruggeri, L Ferrigno, A R Garbuglia, M P Perrone, G Girelli, P Del Porto, E Piccolella, M U Mondelli, P Amoroso, R Cortese, A Nicosia, A Vitelli, A Folgori on behalf of the Acute Hepatitis C Italian Study Group* Gut 2004; 53: 1673-1681. doi:10.1136/gut.2003.037788 [Abstract] [Full text] [PDF] [Request Permissions]
	A role for thrombin in liver fibrosis J Gillibert Duplantier, L Dubuisson, N Senant, G Freyburger, I Laurendeau, J-M Herbert, A Desmoulière, and J Rosenbaum Gut 2004; 53: 1682-1687. doi:10.1136/gut.2003.032136 [Abstract] [Full text] [PDF] [Request Permissions]

Pancreas

	Antidiabetic thiazolidinediones inhibit invasiveness of pancreatic cancer cells via PPAR independent mechanisms A Galli, E Ceni, D W Crabb, T Mello, R Salzano, C Grappone, S Milani, E Surrenti, C Surrenti, and A Casini Gut 2004; 53: 1688-1697. doi:10.1136/gut.2003.031997 [Abstract] [Full text] [PDF] [Request Permissions]

Case reports

	Regression of idiopathic thrombocytopenic purpura after endoscopic mucosal resection of gastric mucosa associated lymphoid tissue lymphoma M Noda, N Mori, K Nomura, K Kojima, S Mitsufuji, I Yamane, S Misawa, and T Okanoue Gut 2004; 53: 1698-1700. doi:10.1136/gut.2003.033555 [Abstract] [Full text] [PDF] [Request Permissions]

Recent advances in basic science

	Apoptosis and colorectal cancer A J M Watson Gut 2004; 53: 1701-1709. doi:10.1136/gut.2004.052704 [Extract] [Full text] [PDF] [Request Permissions]

Recent advances in clinical practice

	Value of genetic testing in the management of pancreatitis D C Whitcomb Gut 2004; 53: 1710-1717. doi:10.1136/gut.2003.015511 [Extract] [Full text] [PDF] [Request Permissions]

JournalScan

	JournalScan Gut 2004; 53: 1718. [Extract] [Full text] [PDF] [Request Permissions]

Letters

	Short segment reflux: acid but no pocket? • Authors’ reply S Nandurkar, K E L McColl, and J Fletcher Gut 2004; 53: 1719. [Extract] [Full text] [PDF] [Request Permissions]
	The role of age in the protection of appendicectomy against ulcerative colitis • Author’s reply G L Adani, U Baccarani, A Risaliti, J Hallas, D Gaist, W Vach, and H T Sørensen Gut 2004; 53: 1719-1720. [Extract] [Full text] [PDF] [Request Permissions]
	Influence of antisecretory drugs on Helicobacter pylori eradication rates • Authors’ reply M Pellegrini, R Urso, G Giorgi, D Cerretani, R C Spiller, and P Sherwood Gut 2004; 53: 1720. [Extract] [Full text] [PDF] [Request Permissions]
	Cytokines in portopulmonary hypertension A M Pellicelli Gut 2004; 53: 1721. [Extract] [Full text] [PDF] [Request Permissions]
	Infallibility of a normal platelet count/spleen diameter ratio in ruling out oesophageal varices? D J Brotman and R G O’Brien Gut 2004; 53: 1721. [Extract] [Full text] [PDF] [Request Permissions]
	Sporadic fundic gland polyps: what happened before? P Declich, E Tavani, S Bellone, M Porcellati, L Pastori, B Omazzi, C Gozzini, A Bortoli, and A Prada Gut 2004; 53: 1721. [Extract] [Full text] [PDF] [Request Permissions]
	To dye or not to dye? That is beyond question! Optimising surveillance colonoscopy is indispensable for detecting dysplasia in ulcerative colitis K Hata, T Watanabe, M Shinozaki, T Kojima, and H Nagawa Gut 2004; 53: 1722. [Extract] [Full text] [PDF] [Request Permissions]

Corrections

	CORRECTION Gut 2004; 53: 1722. [Extract] [Full text] [PDF] [Request Permissions]