Editorials

	Progress report R C Spiller Gut 2004; 53: 317. [Extract] [Full text] [PDF] [Request Permissions]

Digest

	Digest Robin Spiller Gut 2004; 53: 317. [Extract] [Full text] [PDF] [Request Permissions]

Leading articles

	Fibrosis progression in chronic hepatitis C virus infection G W McCaughan and J George Gut 2004; 53: 318-321. doi:10.1136/gut.2003.026393 [Abstract] [Full text] [PDF] [Request Permissions]

Commentaries

	Extracolonic polyposis in familial adenomatous polyposis: so near and yet so far A D Spigelman Gut 2004; 53: 322. doi:10.1136/gut.2003.032227 [Extract] [Full text] [PDF] [Request Permissions]

Stomach

	PDX1 homeobox protein expression in pseudopyloric glands and gastric carcinomas H Sakai, Y Eishi, X-L Li, Y Akiyama, S Miyake, T Takizawa, N Konishi, M Tatematsu, M Koike, and Y Yuasa Gut 2004; 53: 323-330. doi:10.1136/gut.2003.026609 [Abstract] [Full text] [PDF] [Request Permissions]
	Effect of peroxisome proliferator activated receptor ligands on growth and gene expression profiles of gastric cancer cells W K Leung, A H C Bai, V Y W Chan, J Yu, M W Y Chan, K-F To, J-R Wu, K-K Chan, Y-G Fu, F K L Chan, and J J Y Sung Gut 2004; 53: 331-338. doi:10.1136/gut.2003.021105 [Abstract] [Full text] [PDF] [Request Permissions]

GI Snapshot

	Menetrier disease A Cardenas and C Kelly Gut 2004; 53: 330. doi:10.1136/gut.2003.029876 [Extract] [Full text] [PDF] [Request Permissions]
	Answer Gut 2004; 53: 338. doi:10.1136/gut.2003.29876a [Extract] [Full text] [PDF] [Request Permissions]
	Large bowel obstruction due to a benign uterine leiomyoma R P C Chaparala, A S Fawole, N S Ambrose, and A H Chapman Gut 2004; 53: 386. doi:10.1136/gut.2003.028134 [Extract] [Full text] [PDF] [Request Permissions]
	Answer Gut 2004; 53: 430. doi:10.1136/gut.2003.28134a [Extract] [Full text] [PDF] [Request Permissions]

Inflammatory bowel disease

	An interleukin 12 p40-IgG2b fusion protein abrogates T cell mediated inflammation: anti-inflammatory activity in Crohn’s disease and experimental colitis in vivo A Stallmach, T Marth, B Weiß, B M Wittig, A Hombach, C Schmidt, M Neurath, M Zeitz, S Zeuzem, and H Abken Gut 2004; 53: 339-345. doi:10.1136/gut.2003.020107 [Abstract] [Full text] [PDF] [Request Permissions]
	Microscopic colitis: a common diarrhoeal disease. An epidemiological study in Örebro, Sweden, 1993–1998 M Olesen, S Eriksson, J Bohr, G Järnerot, and C Tysk Gut 2004; 53: 346-350. doi:10.1136/gut.2003.014431 [Abstract] [Full text] [PDF] [Request Permissions]
	Appendicectomy has no beneficial effect on admission rates in patients with ulcerative colitis J Hallas, D Gaist, W Vach, and H T Sørensen Gut 2004; 53: 351-354. doi:10.1136/gut.2003.016915 [Abstract] [Full text] [PDF] [Request Permissions]

Pancreas

	Tumour suppression induced by the macrophage activating lipopeptide MALP-2 in an ultrasound guided pancreatic carcinoma mouse model C Schneider, T Schmidt, C Ziske, K Tiemann, K-M Lee, V Uhlinsky, P Behrens, T Sauerbruch, I G H Schmidt-Wolf, P F Mühlradt, J Schmidt, and A Märten Gut 2004; 53: 355-361. doi:10.1136/gut.2003.026005 [Abstract] [Full text] [PDF] [Request Permissions]

Colon

	Enteric neurones modulate the colonic permeability response to luminal bile acids in rat colon in vivo Y Sun, B-M Fihn, H Sjövall, and M Jodal Gut 2004; 53: 362-367. doi:10.1136/gut.2003.015867 [Abstract] [Full text] [PDF] [Request Permissions]
	Behavioural therapy (biofeedback) for solitary rectal ulcer syndrome improves symptoms and mucosal blood flow M E D Jarrett, A V Emmanuel, C J Vaizey, and M A Kamm Gut 2004; 53: 368-370. doi:10.1136/gut.2003.025643 [Abstract] [Full text] [PDF] [Request Permissions]

Colon cancer

	Prognostic significance of microsatellite instability determined by immunohistochemical staining of MSH2 and MLH1 in sporadic T3N0M0 colon cancer Y Parc, S Gueroult, N Mourra, L Serfaty, J-F Fléjou, E Tiret, and R Parc Gut 2004; 53: 371-375. doi:10.1136/gut.2003.019190 [Abstract] [Full text] [PDF] [Request Permissions]
	Detecting diminutive colorectal lesions at colonoscopy: a randomised controlled trial of pan-colonic versus targeted chromoscopy D P Hurlstone, S S Cross, R Slater, D S Sanders, and S Brown Gut 2004; 53: 376-380. doi:10.1136/gut.2003.029868 [Abstract] [Full text] [PDF] [Request Permissions]
	Duodenal adenomatosis in familial adenomatous polyposis S Bülow, J Björk, I J Christensen, O Fausa, H Järvinen, F Moesgaard, and H F A Vasen Gut 2004; 53: 381-386. doi:10.1136/gut.2003.027771 [Abstract] [Full text] [PDF] [Request Permissions]
	The Department of Health’s "two week standard" for bowel cancer: is it working? K Flashman, D P O’Leary, A Senapati, and M R Thompson Gut 2004; 53: 387-391. doi:10.1136/gut.2003.020503 [Abstract] [Full text] [PDF] [Request Permissions]

Liver

	Severe hepatic injury in interleukin 18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivo S Finotto, J Siebler, M Hausding, M Schipp, S Wirtz, S Klein, M Protschka, A Doganci, H A Lehr, C Trautwein, R Khosravi-Fahr, D Strand, A Lohse, P R Galle, M Blessing, and M F Neurath Gut 2004; 53: 392-400. doi:10.1136/gut.2003.018572 [Abstract] [Full text] [PDF] [Request Permissions]
	Improved characterisation of histologically proven liver tumours by contrast enhanced ultrasonography during the portal venous and specific late phase of SHU 508A C F Dietrich, A Ignee, J Trojan, C Fellbaum, and G Schuessler Gut 2004; 53: 401-405. doi:10.1136/gut.2003.026260 [Abstract] [Full text] [PDF] [Request Permissions]
	Steatosis affects chronic hepatitis C progression in a genotype specific way L Rubbia-Brandt, P Fabris, S Paganin, G Leandro, P-J Male, E Giostra, A Carlotto, L Bozzola, A Smedile, and F Negro Gut 2004; 53: 406-412. doi:10.1136/gut.2003.018770 [Abstract] [Full text] [PDF] [Request Permissions]
	Modest weight loss and physical activity in overweight patients with chronic liver disease results in sustained improvements in alanine aminotransferase, fasting insulin, and quality of life I J Hickman, J R Jonsson, J B Prins, S Ash, D M Purdie, A D Clouston, and E E Powell Gut 2004; 53: 413-419. doi:10.1136/gut.2003.027581 [Abstract] [Full text] [PDF] [Request Permissions]
	Effect of antiviral treatment on evolution of liver steatosis in patients with chronic hepatitis C: indirect evidence of a role of hepatitis C virus genotype 3 in steatosis L Castéra, C Hézode, F Roudot-Thoraval, I Lonjon, E-S Zafrani, J-M Pawlotsky, and D Dhumeaux Gut 2004; 53: 420-424. doi:10.1136/gut.2002.009936 [Abstract] [Full text] [PDF] [Request Permissions]
	Benefit of interferon therapy in hepatocellular carcinoma prevention for individual patients with chronic hepatitis C H Yoshida, R Tateishi, Y Arakawa, M Sata, S Fujiyama, S Nishiguchi, H Ishibashi, G Yamada, O Yokosuka, Y Shiratori, and M Omata Gut 2004; 53: 425-430. doi:10.1136/gut.2003.030353 [Abstract] [Full text] [PDF] [Request Permissions]
	Randomised controlled trial of long term portographic follow up versus variceal band ligation following transjugular intrahepatic portosystemic stent shunt for preventing oesophageal variceal rebleeding D Tripathi, H F Lui, A Helmy, K Dabos, E Forrest, A J Stanley, R Jalan, D N Redhead, and P C Hayes Gut 2004; 53: 431-437. doi:10.1136/gut.2003.013532 [Abstract] [Full text] [PDF] [Request Permissions]

Liver fibrosis

	Hepatic fibrogenesis requires sympathetic neurotransmitters J A Oben, T Roskams, S Yang, H Lin, N Sinelli, M Torbenson, U Smedh, T H Moran, Z Li, J Huang, S A Thomas, and A M Diehl Gut 2004; 53: 438-445. doi:10.1136/gut.2003.026658 [Abstract] [Full text] [PDF] [Request Permissions]
	SLC11A1 promoter gene polymorphisms and fibrosis progression in chronic hepatitis C M Romero-Gómez, M A Montes-Cano, M A Otero-Fernández, B Torres, D Sánchez-Muñoz, F Aguilar, N Barroso, L Gómez-Izquierdo, V M Castellano-Megias, A Núñez-Roldán, J Aguilar-Reina, and M F González-Escribano Gut 2004; 53: 446-450. doi:10.1136/gut.2003.028274 [Abstract] [Full text] [PDF] [Request Permissions]
	Progression of hepatic fibrosis in patients with hepatitis C: a prospective repeat liver biopsy study S D Ryder Gut 2004; 53: 451-455. doi:10.1136/gut.2003.021691 [Abstract] [Full text] [PDF] [Request Permissions]

Recent advances in basic science

	Modulating the intestinal immune system: the role of lymphotoxin and GALT organs T W Spahn and T Kucharzik Gut 2004; 53: 456-465. doi:10.1136/gut.2003.023671 [Extract] [Full text] [PDF] [Request Permissions]

JournalScan

	JournalScan Gut 2004; 53: 466. [Extract] [Full text] [PDF] [Request Permissions]

Letters

	Role of multi-detector row CT angiography in the management of gastric fundal varices • Authors’ reply A Matsumoto, Y Sugano, M Yasuda, K Takimoto, J K Willmann, D Weishaupt, T Böhm, T Pfammatter, and P Bauerfeind Gut 2004; 53: 467. [Extract] [Full text] [PDF] [Request Permissions]
	Primary antiphospholipid syndrome as a new cause of autoimmune pancreatitis • Author’s reply H L Spencer, T Kamisawa, N Funata, and A Okamoto Gut 2004; 53: 468. [Extract] [Full text] [PDF] [Request Permissions]
	Treatment of interferon non-responsive chronic hepatitis C with triple therapy with interferon, ribavirin, and amantidine can be encouraging N Khokhar Gut 2004; 53: 468-469. [Extract] [Full text] [PDF] [Request Permissions]
	Who should perform endoscopic procedures? E Redondo-Cerezo and J García-Cano Gut 2004; 53: 469. [Extract] [Full text] [PDF] [Request Permissions]
	The diagnostic dilemmas in discrimination between pancreatic carcinoma and chronic pancreatitis A Harlozinska-Szmyrka and M Strutynska-Karpinska Gut 2004; 53: 469-470. [Extract] [Full text] [PDF] [Request Permissions]
	Small bowel malignancy in coeliac disease P D Howdle and G K T Holmes Gut 2004; 53: 470. [Extract] [Full text] [PDF] [Request Permissions]
	Submucosal "dissection" in collagenous colitis J D Mitchell, R Teague, R Bolton, and J Lowes Gut 2004; 53: 470. [Extract] [Full text] [PDF] [Request Permissions]
	Responses to endothelin-1 in patients with advanced cirrhosis before and after liver transplantation A Helmy Gut 2004; 53: 470-471. [Extract] [Full text] [PDF] [Request Permissions]
	Germline testing of mismatch repair genes is not aided by prescreening tumours for allelic loss R L Ward and E Mokany Gut 2004; 53: 471-472. doi:10.1136/gut.2003.031716 [Extract] [Full text] [PDF] [Request Permissions]
	Mild respiratory distress after wireless capsule endoscopy F Buchkremer, T Herrmann, and W Stremmel Gut 2004; 53: 472. doi:10.1136/gut.2003.033845 [Extract] [Full text] [PDF] [Request Permissions]
	Late development of cholangiocarcinoma after hepaticojejunostomy due to ampullary carcinoma D Padilla, T Cubo, R Pardo, J M Molina, and J Hernández Gut 2004; 53: 472-473. [Extract] [Full text] [PDF] [Request Permissions]
	Adoptive transfer of genetic susceptibility to Crohn’s disease C Folwaczny, J Glas, T Mussack, and H P Török Gut 2004; 53: 473. [Extract] [Full text] [PDF] [Request Permissions]

Book reviews

	Self Assessment Colour Review of Hepatobiliary Medicine W Rosenberg Gut 2004; 53: 473. [Extract] [Full text] [PDF] [Request Permissions]
	The Inflammatory Bowel Disease Yearbook 2003 D van Heel Gut 2004; 53: 473-474. [Extract] [Full text] [PDF] [Request Permissions]
	Fast Facts: Irritable Bowel Syndrome, 2nd edn D Thompson Gut 2004; 53: 474. [Extract] [Full text] [PDF] [Request Permissions]