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June 2004 (Volume 53, Number 6). [Index by author]

	(Cover illustration)	Leading articles Digest Commentaries Oesophagus Stomach Intestine inflammation Irritable bowel syndrome Inflammatory bowel disease Pancreas Liver Recent advances in clinical practice Recent advances in basic science JournalScan Letters Corrections

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Leading articles

Clinical implications of E-cadherin associated hereditary diffuse gastric cancer
R C Fitzgerald and C Caldas
Gut 2004; 53: 775-778. doi:10.1136/gut.2003.022061 [Abstract] [Full text] [PDF] [Request Permissions]

Digest

Digest
Robin Spiller
Gut 2004; 53: 775. [Extract] [Full text] [PDF] [Request Permissions]

Commentaries

Endoscopic therapy of Barrett’s: what more do we need to know?
J-L Van Laethem and J Devière
Gut 2004; 53: 779-780. doi:10.1136/gut.2003.036392 [Extract] [Full text] [PDF] [Request Permissions]

Balancing the risks and benefits of infliximab in the treatment of inflammatory bowel disease
W J Sandborn and E V Loftus
Gut 2004; 53: 780-782. doi:10.1136/gut.2003.020552 [Extract] [Full text] [PDF] [Request Permissions]

Early events in spontaneous bacterial peritonitis
B A Runyon
Gut 2004; 53: 782-784. doi:10.1136/gut.2003.035311 [Extract] [Full text] [PDF] [Request Permissions]

Oesophagus

5-Aminolevulinic acid photodynamic therapy versus argon plasma coagulation for ablation of Barrett’s oesophagus: a randomised trial
M Hage, P D Siersema, H van Dekken, E W Steyerberg, J Haringsma, W van de Vrie, T E Grool, R L P van Veen, H J C M Sterenborg, and E J Kuipers
Gut 2004; 53: 785-790. doi:10.1136/gut.2003.028860 [Abstract] [Full text] [PDF] [Request Permissions]

Stomach

Gastric damage and granulocyte infiltration induced by indomethacin in tumour necrosis factor receptor 1 (TNF-R1) or inducible nitric oxide synthase (iNOS) deficient mice
M H L P Souza, H. Paula Lemos, R B Oliveira, and F Q Cunha
Gut 2004; 53: 791-796. doi:10.1136/gut.2002.012930 [Abstract] [Full text] [PDF] [Request Permissions]

p27^kip1 regulates the apoptotic response of gastric epithelial cells to Helicobacter pylori
H Eguchi, S Carpentier, S S Kim, and S F Moss
Gut 2004; 53: 797-804. doi:10.1136/gut.2003.032144 [Abstract] [Full text] [PDF] [Request Permissions]

Bax translocation and mitochondrial fragmentation induced by Helicobacter pylori
H Ashktorab, S Frank, A R Khaled, S K Durum, B Kifle, and D T Smoot
Gut 2004; 53: 805-813. doi:10.1136/gut.2003.024372 [Abstract] [Full text] [PDF] [Request Permissions]

Hereditary diffuse gastric cancer: predominance of multiple foci of signet ring cell carcinoma in distal stomach and transitional zone
A Charlton, V Blair, D Shaw, S Parry, P Guilford, and I G Martin
Gut 2004; 53: 814-820. doi:10.1136/gut.2002.010447 [Abstract] [Full text] [PDF] [Request Permissions]

Intestine inflammation

Lactic acid bacteria secrete metabolites retaining anti-inflammatory properties after intestinal transport
S Ménard, C Candalh, J C Bambou, K Terpend, N Cerf-Bensussan, and M Heyman
Gut 2004; 53: 821-828. doi:10.1136/gut.2003.026252 [Abstract] [Full text] [PDF] [Request Permissions]

Irritable bowel syndrome

Association of distinct ${alpha}$ ₂ adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders
H J Kim, M Camilleri, P J Carlson, F Cremonini, I Ferber, D Stephens, S McKinzie, A R Zinsmeister, and R Urrutia
Gut 2004; 53: 829-837. doi:10.1136/gut.2003.030882 [Abstract] [Full text] [PDF] [Request Permissions]

Sexual and physical abuse are not associated with rectal hypersensitivity in patients with irritable bowel syndrome
Y Ringel, W E Whitehead, B B Toner, N E Diamant, Y Hu, H Jia, S I Bangdiwala, and D A Drossman
Gut 2004; 53: 838-842. doi:10.1136/gut.2003.021725 [Abstract] [Full text] [PDF] [Request Permissions]

Inflammatory bowel disease

Opposite evolution in incidence of Crohn’s disease and ulcerative colitis in Northern France (1988–1999)
F Molinié, C Gower-Rousseau, T Yzet, V Merle, B Grandbastien, R Marti, E Lerebours, J-L Dupas, J-F Colombel, J-L Salomez, and A Cortot
Gut 2004; 53: 843-848. doi:10.1136/gut.2003.025346 [Abstract] [Full text] [PDF] [Request Permissions]

Infliximab in inflammatory bowel disease: clinical outcome in a population based cohort from Stockholm County
T Ljung, P Karlén, D Schmidt, P M Hellström, A Lapidus, I Janczewska, U Sjöqvist, and R Löfberg
Gut 2004; 53: 849-853. doi:10.1136/gut.2003.018515 [Abstract] [Full text] [PDF] [Request Permissions]

Pancreas

Dynamic imaging of pancreatic diseases by contrast enhanced coded phase inversion harmonic ultrasonography
M Kitano, M Kudo, K Maekawa, Y Suetomi, H Sakamoto, N Fukuta, R Nakaoka, and T Kawasaki
Gut 2004; 53: 854-859. doi:10.1136/gut.2003.029934 [Abstract] [Full text] [PDF] [Request Permissions]

Liver

Bacterial DNA activates cell mediated immune response and nitric oxide overproduction in peritoneal macrophages from patients with cirrhosis and ascites
R Francés, C Muñoz, P Zapater, F Uceda, I Gascón, S Pascual, M Pérez-Mateo, and J Such
Gut 2004; 53: 860-864. doi:10.1136/gut.2003.027425 [Abstract] [Full text] [PDF] [Request Permissions]

Asymptomatic primary biliary cirrhosis: clinical features, prognosis, and symptom progression in a large population based cohort
M I Prince, A Chetwynd, W L Craig, J V Metcalf, and O F W James
Gut 2004; 53: 865-870. doi:10.1136/gut.2003.023937 [Abstract] [Full text] [PDF] [Request Permissions]

Increased cancer risk in heavy drinkers with the alcohol dehydrogenase 1C*1 allele, possibly due to salivary acetaldehyde
J P Visapää, K Götte, M Benesova, J Li, N Homann, C Conradt, H Inoue, M Tisch, K Hörrmann, S Väkeväinen, M Salaspuro, and H K Seitz
Gut 2004; 53: 871-876. doi:10.1136/gut.2003.018994 [Abstract] [Full text] [PDF] [Request Permissions]

Increased hepatic platelet activating factor (PAF) and PAF receptors in carbon tetrachloride induced liver cirrhosis
Y Yang, E M Nemoto, S A K Harvey, V M Subbotin, and C R Gandhi
Gut 2004; 53: 877-883. doi:10.1136/gut.2003.024893 [Abstract] [Full text] [PDF] [Request Permissions]

Bone marrow engraftment in a rodent model of chemical carcinogenesis but no role in the histogenesis of hepatocellular carcinoma
H Ishikawa, K Nakao, K Matsumoto, D Nishimura, T Ichikawa, K Hamasaki, and K Eguchi
Gut 2004; 53: 884-889. doi:10.1136/gut.2003.026047 [Abstract] [Full text] [PDF] [Request Permissions]

Recent advances in clinical practice

PROSPECTS FOR EXTRACORPOREAL LIVER SUPPORT
R Jalan, S Sen, and R Williams
Gut 2004; 53: 890-898. doi:10.1136/gut.2003.024919 [Extract] [Full text] [PDF] [Request Permissions]

Recent advances in basic science

STEM CELL IN GASTROINTESTINAL STRUCTURE AND NEOPLASTIC DEVELOPMENT
M Brittan and N A Wright
Gut 2004; 53: 899-910. doi:10.1136/gut.2003.025478 [Extract] [Full text] [PDF] [Request Permissions]

JournalScan

JournalScan
Gut 2004; 53: 911. [Extract] [Full text] [PDF] [Request Permissions]

Letters

H pylori infection and reflux oesophagitis
J Kountouras, C Zavos, and D Chatzopoulos
Gut 2004; 53: 912. [Extract] [Full text] [PDF] [Request Permissions]

Research trends in British gastroenterology: publication rates in newly appointed NHS consultants over a nine year period
A D Hopper, R Atkinson, L Prtak, and D S Sanders
Gut 2004; 53: 913. [Extract] [Full text] [PDF] [Request Permissions]

Diagnostic endoscopy: does it help?
R G Fiddian-Green
Gut 2004; 53: 913. [Extract] [Full text] [PDF] [Request Permissions]

Prediction of oesophageal varices with platelet count/spleen diameter ratio or platelets alone • Author’s reply
D Thabut, V Ratziu, J-B Trabut, T Poynard, E G Giannini, F Botta, and R Testa
Gut 2004; 53: 913-915. [Extract] [Full text] [PDF] [Request Permissions]

Computed tomography colonography: colon examination or Pandora’s box
R Iannaccone, A Laghi, C Catalano, F Mangiapane, D Marin, and R Passariello
Gut 2004; 53: 915. [Extract] [Full text] [PDF] [Request Permissions]

Patients’ understanding of colonoscopy risk is suboptimal
R J Makins, D S Rampton, and A B Ballinger
Gut 2004; 53: 915. [Extract] [Full text] [PDF] [Request Permissions]

Corrections

CORRECTION
Gut 2004; 53: 915. [Extract] [Full text] [PDF] [Request Permissions]

Cover

Phenotype of hereditary diffuse gastric cancer (from the paper by Charlton et al, pp 814-820).

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	Clinical implications of E-cadherin associated hereditary diffuse gastric cancer R C Fitzgerald and C Caldas Gut 2004; 53: 775-778. doi:10.1136/gut.2003.022061 [Abstract] [Full text] [PDF] [Request Permissions]

	Digest Robin Spiller Gut 2004; 53: 775. [Extract] [Full text] [PDF] [Request Permissions]

	Endoscopic therapy of Barrett’s: what more do we need to know? J-L Van Laethem and J Devière Gut 2004; 53: 779-780. doi:10.1136/gut.2003.036392 [Extract] [Full text] [PDF] [Request Permissions]

	Balancing the risks and benefits of infliximab in the treatment of inflammatory bowel disease W J Sandborn and E V Loftus Gut 2004; 53: 780-782. doi:10.1136/gut.2003.020552 [Extract] [Full text] [PDF] [Request Permissions]

	Early events in spontaneous bacterial peritonitis B A Runyon Gut 2004; 53: 782-784. doi:10.1136/gut.2003.035311 [Extract] [Full text] [PDF] [Request Permissions]

	5-Aminolevulinic acid photodynamic therapy versus argon plasma coagulation for ablation of Barrett’s oesophagus: a randomised trial M Hage, P D Siersema, H van Dekken, E W Steyerberg, J Haringsma, W van de Vrie, T E Grool, R L P van Veen, H J C M Sterenborg, and E J Kuipers Gut 2004; 53: 785-790. doi:10.1136/gut.2003.028860 [Abstract] [Full text] [PDF] [Request Permissions]

	Gastric damage and granulocyte infiltration induced by indomethacin in tumour necrosis factor receptor 1 (TNF-R1) or inducible nitric oxide synthase (iNOS) deficient mice M H L P Souza, H. Paula Lemos, R B Oliveira, and F Q Cunha Gut 2004; 53: 791-796. doi:10.1136/gut.2002.012930 [Abstract] [Full text] [PDF] [Request Permissions]

	p27^kip1 regulates the apoptotic response of gastric epithelial cells to Helicobacter pylori H Eguchi, S Carpentier, S S Kim, and S F Moss Gut 2004; 53: 797-804. doi:10.1136/gut.2003.032144 [Abstract] [Full text] [PDF] [Request Permissions]

	Bax translocation and mitochondrial fragmentation induced by Helicobacter pylori H Ashktorab, S Frank, A R Khaled, S K Durum, B Kifle, and D T Smoot Gut 2004; 53: 805-813. doi:10.1136/gut.2003.024372 [Abstract] [Full text] [PDF] [Request Permissions]

	Hereditary diffuse gastric cancer: predominance of multiple foci of signet ring cell carcinoma in distal stomach and transitional zone A Charlton, V Blair, D Shaw, S Parry, P Guilford, and I G Martin Gut 2004; 53: 814-820. doi:10.1136/gut.2002.010447 [Abstract] [Full text] [PDF] [Request Permissions]

	Lactic acid bacteria secrete metabolites retaining anti-inflammatory properties after intestinal transport S Ménard, C Candalh, J C Bambou, K Terpend, N Cerf-Bensussan, and M Heyman Gut 2004; 53: 821-828. doi:10.1136/gut.2003.026252 [Abstract] [Full text] [PDF] [Request Permissions]

	Association of distinct ${alpha}$ ₂ adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders H J Kim, M Camilleri, P J Carlson, F Cremonini, I Ferber, D Stephens, S McKinzie, A R Zinsmeister, and R Urrutia Gut 2004; 53: 829-837. doi:10.1136/gut.2003.030882 [Abstract] [Full text] [PDF] [Request Permissions]

	Sexual and physical abuse are not associated with rectal hypersensitivity in patients with irritable bowel syndrome Y Ringel, W E Whitehead, B B Toner, N E Diamant, Y Hu, H Jia, S I Bangdiwala, and D A Drossman Gut 2004; 53: 838-842. doi:10.1136/gut.2003.021725 [Abstract] [Full text] [PDF] [Request Permissions]

	Opposite evolution in incidence of Crohn’s disease and ulcerative colitis in Northern France (1988–1999) F Molinié, C Gower-Rousseau, T Yzet, V Merle, B Grandbastien, R Marti, E Lerebours, J-L Dupas, J-F Colombel, J-L Salomez, and A Cortot Gut 2004; 53: 843-848. doi:10.1136/gut.2003.025346 [Abstract] [Full text] [PDF] [Request Permissions]

	Infliximab in inflammatory bowel disease: clinical outcome in a population based cohort from Stockholm County T Ljung, P Karlén, D Schmidt, P M Hellström, A Lapidus, I Janczewska, U Sjöqvist, and R Löfberg Gut 2004; 53: 849-853. doi:10.1136/gut.2003.018515 [Abstract] [Full text] [PDF] [Request Permissions]

	Dynamic imaging of pancreatic diseases by contrast enhanced coded phase inversion harmonic ultrasonography M Kitano, M Kudo, K Maekawa, Y Suetomi, H Sakamoto, N Fukuta, R Nakaoka, and T Kawasaki Gut 2004; 53: 854-859. doi:10.1136/gut.2003.029934 [Abstract] [Full text] [PDF] [Request Permissions]

	Bacterial DNA activates cell mediated immune response and nitric oxide overproduction in peritoneal macrophages from patients with cirrhosis and ascites R Francés, C Muñoz, P Zapater, F Uceda, I Gascón, S Pascual, M Pérez-Mateo, and J Such Gut 2004; 53: 860-864. doi:10.1136/gut.2003.027425 [Abstract] [Full text] [PDF] [Request Permissions]

	Asymptomatic primary biliary cirrhosis: clinical features, prognosis, and symptom progression in a large population based cohort M I Prince, A Chetwynd, W L Craig, J V Metcalf, and O F W James Gut 2004; 53: 865-870. doi:10.1136/gut.2003.023937 [Abstract] [Full text] [PDF] [Request Permissions]

	*Increased cancer risk in heavy drinkers with the alcohol dehydrogenase 1C1 allele, possibly due to salivary acetaldehyde** J P Visapää, K Götte, M Benesova, J Li, N Homann, C Conradt, H Inoue, M Tisch, K Hörrmann, S Väkeväinen, M Salaspuro, and H K Seitz Gut 2004; 53: 871-876. doi:10.1136/gut.2003.018994 [Abstract] [Full text] [PDF] [Request Permissions]

	Increased hepatic platelet activating factor (PAF) and PAF receptors in carbon tetrachloride induced liver cirrhosis Y Yang, E M Nemoto, S A K Harvey, V M Subbotin, and C R Gandhi Gut 2004; 53: 877-883. doi:10.1136/gut.2003.024893 [Abstract] [Full text] [PDF] [Request Permissions]

	Bone marrow engraftment in a rodent model of chemical carcinogenesis but no role in the histogenesis of hepatocellular carcinoma H Ishikawa, K Nakao, K Matsumoto, D Nishimura, T Ichikawa, K Hamasaki, and K Eguchi Gut 2004; 53: 884-889. doi:10.1136/gut.2003.026047 [Abstract] [Full text] [PDF] [Request Permissions]

	PROSPECTS FOR EXTRACORPOREAL LIVER SUPPORT R Jalan, S Sen, and R Williams Gut 2004; 53: 890-898. doi:10.1136/gut.2003.024919 [Extract] [Full text] [PDF] [Request Permissions]

	STEM CELL IN GASTROINTESTINAL STRUCTURE AND NEOPLASTIC DEVELOPMENT M Brittan and N A Wright Gut 2004; 53: 899-910. doi:10.1136/gut.2003.025478 [Extract] [Full text] [PDF] [Request Permissions]

	JournalScan Gut 2004; 53: 911. [Extract] [Full text] [PDF] [Request Permissions]

	H pylori infection and reflux oesophagitis J Kountouras, C Zavos, and D Chatzopoulos Gut 2004; 53: 912. [Extract] [Full text] [PDF] [Request Permissions]

	Research trends in British gastroenterology: publication rates in newly appointed NHS consultants over a nine year period A D Hopper, R Atkinson, L Prtak, and D S Sanders Gut 2004; 53: 913. [Extract] [Full text] [PDF] [Request Permissions]

	Diagnostic endoscopy: does it help? R G Fiddian-Green Gut 2004; 53: 913. [Extract] [Full text] [PDF] [Request Permissions]

	Prediction of oesophageal varices with platelet count/spleen diameter ratio or platelets alone • Author’s reply D Thabut, V Ratziu, J-B Trabut, T Poynard, E G Giannini, F Botta, and R Testa Gut 2004; 53: 913-915. [Extract] [Full text] [PDF] [Request Permissions]

	Computed tomography colonography: colon examination or Pandora’s box R Iannaccone, A Laghi, C Catalano, F Mangiapane, D Marin, and R Passariello Gut 2004; 53: 915. [Extract] [Full text] [PDF] [Request Permissions]

	Patients’ understanding of colonoscopy risk is suboptimal R J Makins, D S Rampton, and A B Ballinger Gut 2004; 53: 915. [Extract] [Full text] [PDF] [Request Permissions]

	CORRECTION Gut 2004; 53: 915. [Extract] [Full text] [PDF] [Request Permissions]