Leading articles

	When saliva meets acid: chemical warfare at the oesophagogastric junction K E L McColl Gut 2005; 54: 1-3. doi:10.1136/gut.2004.047126 [Abstract] [Full text] [PDF] [Request Permissions]

Digest

	Digest Robin Spiller Gut 2005; 54: 1. [Extract] [Full text] [PDF] [Request Permissions]

Commentaries

	Immune regulation and colitis: suppression of acute inflammation allows the development of chronic inflammatory bowel disease B Eksteen, L S K Walker, and D H Adams Gut 2005; 54: 4-6. doi:10.1136/gut.2004.047084 [Extract] [Full text] [PDF] [Request Permissions]
	Will worms really cure Crohn’s disease? G L Radford-Smith Gut 2005; 54: 6-8. doi:10.1136/gut.2004.044917 [Extract] [Full text] [PDF] [Request Permissions]
	Resistance to lamivudine therapy: is there more than meets the eye? G Dusheiko and A Bertoletti Gut 2005; 54: 9-10. doi:10.1136/gut.2004.047548 [Extract] [Full text] [PDF] [Request Permissions]

Gastro-oesophageal reflux

	Dietary intake and the risk of gastro-oesophageal reflux disease: a cross sectional study in volunteers H B El-Serag, J A Satia, and L Rabeneck Gut 2005; 54: 11-17. doi:10.1136/gut.2004.040337 [Abstract] [Full text] [PDF] [Request Permissions]

Stomach

	Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin A Asakawa, A Inui, M Fujimiya, R Sakamaki, N Shinfuku, Y Ueta, M M Meguid, and M Kasuga Gut 2005; 54: 18-24. doi:10.1136/gut.2004.038737 [Abstract] [Full text] [PDF] [Request Permissions]
	Human peripheral and gastric lymphocyte responses to Helicobacter pylori NapA and AphC differ in infected and uninfected individuals H J Windle, Y S Ang, V A Morales, R McManus, and D Kelleher Gut 2005; 54: 25-32. doi:10.1136/gut.2003.025494 [Abstract] [Full text] [PDF] [Request Permissions]
	Pericryptal fibroblast sheath in intestinal metaplasia and gastric carcinoma H Mutoh, S Sakurai, K Satoh, H Osawa, T Tomiyama, H Kita, T Yoshida, K Tamada, H Yamamoto, N Isoda, K Ido, and K Sugano Gut 2005; 54: 33-39. doi:10.1136/gut.2004.042770 [Abstract] [Full text] [PDF] [Request Permissions]

Gastrointestinal cancer

	Predictive value of alarm features in a rapid access upper gastrointestinal cancer service N Kapoor, A Bassi, R Sturgess, and K Bodger Gut 2005; 54: 40-45. doi:10.1136/gut.2004.039438 [Abstract] [Full text] [PDF] [Request Permissions]

Coeliac disease

	Recombinant human interleukin 10 suppresses gliadin dependent T cell activation in ex vivo cultured coeliac intestinal mucosa V M Salvati, G Mazzarella, C Gianfrani, M K Levings, R Stefanile, B De Giulio, G Iaquinto, N Giardullo, S Auricchio, M G Roncarolo, and R Troncone Gut 2005; 54: 46-53. doi:10.1136/gut.2003.023150 [Abstract] [Full text] [PDF] [Request Permissions]
	Malignant lymphomas in coeliac disease: evidence of increased risks for lymphoma types other than enteropathy-type T cell lymphoma K E Smedby, M Åkerman, H Hildebrand, B Glimelius, A Ekbom, and J Askling Gut 2005; 54: 54-59. doi:10.1136/gut.2003.032094 [Abstract] [Full text] [PDF] [Request Permissions]

Inflammatory bowel disease

	CD4+ T cell mediated intestinal immunity: chronic inflammation versus immune regulation A M Westendorf, M Templin, R Geffers, S Deppenmeier, A D Gruber, M Probst-Kepper, W Hansen, R S Liblau, F Gunzer, D Bruder, and J Buer Gut 2005; 54: 60-69. doi:10.1136/gut.2003.037663 [Abstract] [Full text] [PDF] [Request Permissions]
	CD40 antisense oligonucleotide inhibition of trinitrobenzene sulphonic acid induced rat colitis D Gao, A H Wagner, S Fankhaenel, T Stojanovic, S Schweyer, S Panzner, and M Hecker Gut 2005; 54: 70-77. doi:10.1136/gut.2003.029587 [Abstract] [Full text] [PDF] [Request Permissions]
	CD4+CD45RBHi T cell transfer induced colitis in mice is accompanied by osteopenia which is treatable with recombinant human osteoprotegerin F R Byrne, S Morony, K Warmington, Z Geng, H L Brown, S A Flores, M Fiorino, S L Yin, D Hill, V Porkess, D Duryea, J K Pretorius, S Adamu, R Manuokian, D M Danilenko, I Sarosi, D L Lacey, P J Kostenuik, and G Senaldi Gut 2005; 54: 78-86. doi:10.1136/gut.2003.035113 [Abstract] [Full text] [PDF] [Request Permissions]
	Trichuris suis therapy in Crohn’s disease R W Summers, D E Elliott, J F Urban, Jr, R Thompson, and J V Weinstock Gut 2005; 54: 87-90. doi:10.1136/gut.2004.041749 [Abstract] [Full text] [PDF] [Request Permissions]
	PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis E V Loftus, Jr, G C Harewood, C G Loftus, W J Tremaine, W S Harmsen, A R Zinsmeister, D A Jewell, and W J Sandborn Gut 2005; 54: 91-96. doi:10.1136/gut.2004.046615 [Abstract] [Full text] [PDF] [Request Permissions]

Miscellanea

	An unusual cause of diarrhoea in a patient with colitis M Karmo, J Goh, R Boulton, and D S A Sanders Gut 2005; 54: 77. doi:10.1136/gut.2004.043240 [Extract] [Full text] [PDF] [Request Permissions]
	Vomiting in the recently anticoagulated patient R A Cahill, S Siddique, and J O’Connor Gut 2005; 54: 90. doi:10.1136/gut.2004.040071 [Extract] [Full text] [PDF] [Request Permissions]
	EDITOR’S QUIZ: GI SNAPSHOT Gut 2005; 54: 96. [Extract] [Full text] [PDF] [Request Permissions]
	EDITOR’S QUIZ: GI SNAPSHOT Gut 2005; 54: 102. [Extract] [Full text] [PDF] [Request Permissions]
	Oesophageal ulceration: more than meets the naked eye? J W Cash, C McConville, D O’Rourke, and T Harding Gut 2005; 54: 127. doi:10.1136/gut.2003.033308 [Extract] [Full text] [PDF] [Request Permissions]
	EDITOR’S QUIZ: GI SNAPSHOT Gut 2005; 54: 133. [Extract] [Full text] [PDF] [Request Permissions]
	Chronic diarrhoea after allogenic bone marrow transplantation B Radu, M Allez, J-M Gornet, M Lemann, G Socie, E Gluckman, and A-M Zagdanski Gut 2005; 54: 161. doi:10.1136/gut.2004.041335 [Extract] [Full text] [PDF] [Request Permissions]
	EDITOR’S QUIZ: GI SNAPSHOTS Gut 2005; 54: 174. [Extract] [Full text] [PDF] [Request Permissions]

Colorectal cancer

	Cost effectiveness of a new strategy to identify HNPCC patients W Kievit, J H F M de Bruin, E M M Adang, J L Severens, J H Kleibeuker, R H Sijmons, T J Ruers, F M Nagengast, H F A Vasen, J H J M van Krieken, M J L Ligtenberg, and N Hoogerbrugge Gut 2005; 54: 97-102. doi:10.1136/gut.2004.039123 [Abstract] [Full text] [PDF] [Request Permissions]
	Low level microsatellite instability may be associated with reduced cancer specific survival in sporadic stage C colorectal carcinoma C M Wright, O F Dent, R C Newland, M Barker, P H Chapuis, E L Bokey, J P Young, B A Leggett, J R Jass, and G A Macdonald Gut 2005; 54: 103-108. doi:10.1136/gut.2003.034579 [Abstract] [Full text] [PDF] [Request Permissions]

Pancreatic cancer

	Dominant negative inhibitors of signalling through the phosphoinositol 3-kinase pathway for gene therapy of pancreatic cancer V Stoll, V Calleja, G Vassaux, J Downward, and N R Lemoine Gut 2005; 54: 109-116. doi:10.1136/gut.2004.046706 [Abstract] [Full text] [PDF] [Request Permissions]

Liver

	Adiponectin and its receptors in non-alcoholic steatohepatitis S Kaser, A Moschen, A Cayon, A Kaser, J Crespo, F Pons-Romero, C F Ebenbichler, J R Patsch, and H Tilg Gut 2005; 54: 117-121. doi:10.1136/gut.2003.037010 [Abstract] [Full text] [PDF] [Request Permissions]
	Hepatic triglyceride content and its relation to body adiposity: a magnetic resonance imaging and proton magnetic resonance spectroscopy study E L Thomas, G Hamilton, N Patel, R O’Dwyer, C J Doré, R D Goldin, J D Bell, and S D Taylor-Robinson Gut 2005; 54: 122-127. doi:10.1136/gut.2003.036566 [Abstract] [Full text] [PDF] [Request Permissions]
	Hepatic vein transit times using a microbubble agent can predict disease severity non-invasively in patients with hepatitis C A K P Lim, S D Taylor-Robinson, N Patel, R J Eckersley, R D Goldin, G Hamilton, G R Foster, H C Thomas, D O Cosgrove, and M J K Blomley Gut 2005; 54: 128-133. doi:10.1136/gut.2003.030965 [Abstract] [Full text] [PDF] [Request Permissions]
	Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury S Sanz, J B Pucilowska, S Liu, C M Rodríguez-Ortigosa, P K Lund, D A Brenner, C R Fuller, J G Simmons, A Pardo, M-L Martínez-Chantar, J A Fagin, and J Prieto Gut 2005; 54: 134-141. doi:10.1136/gut.2003.024505 [Abstract] [Full text] [PDF] [Request Permissions]
	Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis L Xu, A Y Hui, E Albanis, M J Arthur, S M O’Byrne, W S Blaner, P Mukherjee, S L Friedman, and F J Eng Gut 2005; 54: 142-151. doi:10.1136/gut.2004.042127 [Abstract] [Full text] [PDF] [Request Permissions]
	High frequency of functional anti-YMDD and -mutant cytotoxic T lymphocytes after in vitro expansion correlates with successful response to lamivudine therapy for chronic hepatitis B C-L Lin, S-L Tsai, T-H Lee, R-N Chien, S-K Liao, and Y-F Liaw Gut 2005; 54: 152-161. doi:10.1136/gut.2003.032920 [Abstract] [Full text] [PDF] [Request Permissions]

Recent advances in clinical practice

	Genotypes and phenotypes in Crohn’s disease: do they help in clinical management? C Gasche and P Grundtner Gut 2005; 54: 162-167. doi:10.1136/gut.2003.035600 [Extract] [Full text] [Erratum] [PDF] [Request Permissions]

JournalScan

	JournalScan Gut 2005; 54: 168. [Extract] [Full text] [PDF] [Request Permissions]

Letters

	An alternative to prophylactic colectomy for colon cancer prevention in HNPCC syndrome S Olschwang, P Laurent-Puig, F Eisinger, and B Millat Gut 2005; 54: 169. doi:10.1136/gut.2004.047613 [Extract] [Full text] [PDF] [Request Permissions]
	Serum pro-hepcidin: measuring active hepcidin or a non-functional precursor? M J Brookes, N K Sharma, C Tselepis, and T H Iqbal Gut 2005; 54: 169-170. doi:10.1136/gut.2004.047639 [Extract] [Full text] [PDF] [Request Permissions]
	Use of oesophageal dilatation in clinical practice S J O Veldhuyzen van Zanten Gut 2005; 54: 170. doi:10.1136/gut.2004.047605 [Extract] [Full text] [PDF] [Request Permissions]
	Variant Creutzfeldt-Jakob disease: update M G Bramble and J Ironside Gut 2005; 54: 170. doi:10.1136/gut.2004.048231 [Extract] [Full text] [PDF] [Request Permissions]
	Is mesalazine really safe for use in breastfeeding mothers? D A Silverman, J Ford, I Shaw, and C S J Probert Gut 2005; 54: 170-171. doi:10.1136/gut.2004.048058 [Extract] [Full text] [PDF] [Request Permissions]
	Duodenal adenoma and cancer in FAP A R Latchford and R K S Phillips Gut 2005; 54: 171. doi:10.1136/gut.2004.049858 [Extract] [Full text] [PDF] [Request Permissions]
	Treatment of recurrent gastrointestinal haemorrhage in a patient with von Willebrand’s disease with octreotide LAR and propranolol N Krikis, K Tziomalos, V Perifanis, S Vakalopoulou, A Karagiannis, V Garipidou, and F Harsoulis Gut 2005; 54: 171-172. doi:10.1136/gut.2004.049031 [Extract] [Full text] [PDF] [Request Permissions]
	Antiviral treatment initiation costs in chronic hepatitis C U Siebert, J Wasem, S Rossol, G Sroczynski, P Aidelsburger, U Ravens-Sieberer, B M Kurth, M P Manns, J G McHutchison, and J B Wong Gut 2005; 54: 172-173. [Extract] [Full text] [PDF] [Request Permissions]
	Adherence to BSG adenoma surveillance guidelines will reduce colonoscopic workload R C Thomas, C Selinger, and M D Rutter Gut 2005; 54: 173. doi:10.1136/gut.2004.049924 [Extract] [Full text] [PDF] [Request Permissions]

Corrections

	CORRECTION Gut 2005; 54: 173. doi:10.1136/gut.2003.026963corr1 [Extract] [Full text] [PDF] [Request Permissions]