Leading articles

	Brain imaging and its implications for studying centrally targeted treatments in irritable bowel syndrome: a primer for gastroenterologists D A Drossman Gut 2005; 54: 569-573. doi:10.1136/gut.2004.058446 [Abstract] [Full text] [PDF] [Request Permissions]

Digest

	Digest Robin Spiller Gut 2005; 54: 569. [Extract] [Full text] [PDF] [Request Permissions]

Commentaries

	Clinical epidemiology—how important now? V Binder Gut 2005; 54: 574-575. doi:10.1136/gut.2004.055111 [Extract] [Full text] [PDF] [Request Permissions]
	Increased deoxycholic acid absorption and gall stones in acromegalic patients treated with octreotide: more evidence for a connection between slow transit constipation and gall stones A F Hofmann Gut 2005; 54: 575-578. doi:10.1136/gut.2004.048074 [Extract] [Full text] [PDF] [Request Permissions]
	Reversal of DNA hypomethylation by folic acid supplements: possible role in colorectal cancer prevention J C Mathers Gut 2005; 54: 579-581. doi:10.1136/gut.2004.059881 [Extract] [Full text] [PDF] [Request Permissions]
	Autoimmune pancreatitis—also a Western disease R Sutton Gut 2005; 54: 581-583. doi:10.1136/gut.2004.058438 [Extract] [Full text] [PDF] [Request Permissions]

Helicobacter

	Roles of virD4 and cagG genes in the cag pathogenicity island of Helicobacter pylori using a Mongolian gerbil model H Saito, Y Yamaoka, S Ishizone, F Maruta, A Sugiyama, D Y Graham, K Yamauchi, H Ota, and S Miyagawa Gut 2005; 54: 584-590. doi:10.1136/gut.2004.058982 [Abstract] [Full text] [PDF] [Request Permissions]

Gastric cancer

	Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts Y Min, Y Adachi, H Yamamoto, A Imsumran, Y Arimura, T Endo, Y Hinoda, C-T Lee, S Nadaf, D P Carbone, and K Imai Gut 2005; 54: 591-600. doi:10.1136/gut.2004.048926 [Abstract] [Full text] [PDF] [Request Permissions]

Irritable bowel syndrome

	Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome V Morgan, D Pickens, S Gautam, R Kessler, and H Mertz Gut 2005; 54: 601-607. doi:10.1136/gut.2004.047423 [Abstract] [Full text] [PDF] [Request Permissions]

Gut motility

	Role of cyclooxygenases 1 and 2 in the modulation of neuromuscular functions in the distal colon of humans and mice M Fornai, C Blandizzi, R Colucci, L Antonioli, N Bernardini, C Segnani, B Baragatti, S Barogi, P Berti, R Spisni, and M Del Tacca Gut 2005; 54: 608-616. doi:10.1136/gut.2004.053322 [Abstract] [Full text] [PDF] [Request Permissions]

Miscellanea

	An unusual case of terminal ileal stricture D R Gaya, A J Morris, and J J Going Gut 2005; 54: 616. doi:10.1136/gut.2004.048769 [Extract] [Full text] [PDF] [Request Permissions]
	How to evaluate a gastric submucosal tumour in a patient with haematemesis? J Boujaoude, B Abboud, and G Abadjian Gut 2005; 54: 629. doi:10.1136/gut.2004.054874 [Extract] [Full text] [PDF] [Request Permissions]
	EDITOR’S QUIZ: GI SNAPSHOT Gut 2005; 54: 653. [Extract] [Full text] [PDF] [Request Permissions]
	Liver failure after delivery C J M de Groot, G M van Goor, M F Stolk, H J Metselaar, H L A Janssen, G Kazemier, P E Zondervan, and I R Wanless Gut 2005; 54: 672. doi:10.1136/gut.2004.045252 [Extract] [Full text] [PDF] [Request Permissions]
	EDITOR’S QUIZ: GI SNAPSHOT Gut 2005; 54: 697. [Extract] [Full text] [PDF] [Request Permissions]
	EDITOR’S QUIZ: GI SNAPSHOT Gut 2005; 54: 709. [Extract] [Full text] [PDF] [Request Permissions]

Inflammatory bowel disease

	Risk of haematopoietic cancer in patients with inflammatory bowel disease J Askling, L Brandt, A Lapidus, P Karlén, M Björkholm, R Löfberg, and A Ekbom Gut 2005; 54: 617-622. doi:10.1136/gut.2004.051771 [Abstract] [Full text] [PDF] [Request Permissions]
	Activation of RegIIIß/ and interferon expression in the intestinal tract of SCID mice: an innate response to bacterial colonisation of the gut S A Keilbaugh, M E Shin, R F Banchereau, L D McVay, N Boyko, D Artis, J J Cebra, and G D Wu Gut 2005; 54: 623-629. doi:10.1136/gut.2004.056028 [Abstract] [Full text] [PDF] [Request Permissions]

Colon

	Octreotide induced prolongation of colonic transit increases faecal anaerobic bacteria, bile acid metabolising enzymes, and serum deoxycholic acid in patients with acromegaly L A Thomas, M J Veysey, G M Murphy, D Russell-Jones, G L French, J A H Wass, and R H Dowling Gut 2005; 54: 630-635. doi:10.1136/gut.2003.028431 [Abstract] [Full text] [PDF] [Request Permissions]

Colorectal cancer

	Association between family history and mismatch repair in colorectal cancer R P Coggins, L Cawkwell, S M Bell, G P Crockford, P Quirke, P J Finan, and D T Bishop Gut 2005; 54: 636-642. doi:10.1136/gut.2003.017517 [Abstract] [Full text] [PDF] [Request Permissions]
	The C/C–13910 genotype of adult-type hypolactasia is associated with an increased risk of colorectal cancer in the Finnish population H Rasinperä, C Forsblom, N S Enattah, P Halonen, K Salo, M Victorzon, J-P Mecklin, H Järvinen, S Enholm, G Sellick, H Alazzouzi, R Houlston, J Robinson, P-H Groop, I Tomlinson, S Schwartz, Jr, L A Aaltonen, I Järvelä The FinnDiane Study Group Gut 2005; 54: 643-647. doi:10.1136/gut.2004.055939 [Abstract] [Full text] [PDF] [Request Permissions]
	Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma M Pufulete, R Al-Ghnaniem, A Khushal, P Appleby, N Harris, S Gout, P W Emery, and T A B Sanders Gut 2005; 54: 648-653. doi:10.1136/gut.2004.054718 [Abstract] [Full text] [PDF] [Request Permissions]
	Increased microvascular blood content is an early event in colon carcinogenesis R K Wali, H K Roy, Y L Kim, Y Liu, J L Koetsier, D P Kunte, M J Goldberg, V Turzhitsky, and V Backman Gut 2005; 54: 654-660. doi:10.1136/gut.2004.056010 [Abstract] [Full text] [PDF] [Request Permissions]
	Impaired CD95 expression predisposes for recurrence in curatively resected colon carcinoma: clinical evidence for immunoselection and CD95L mediated control of minimal residual disease J Sträter, U Hinz, C Hasel, U Bhanot, G Mechtersheimer, T Lehnert, and P Möller Gut 2005; 54: 661-665. doi:10.1136/gut.2004.052696 [Abstract] [Full text] [PDF] [Request Permissions]
	Placenta growth factor expression is correlated with survival of patients with colorectal cancer S-C Wei, P-N Tsao, S-C Yu, C-T Shun, J-J Tsai-Wu, C H H Wu, Y-N Su, F-J Hsieh, and J-M Wong Gut 2005; 54: 666-672. doi:10.1136/gut.2004.050831 [Abstract] [Full text] [PDF] [Request Permissions]

Liver

	Thrombospondin 1 acts as a strong promoter of transforming growth factor ß effects via two distinct mechanisms in hepatic stellate cells K Breitkopf, I Sawitza, J H Westhoff, L Wickert, S Dooley, and A M Gressner Gut 2005; 54: 673-681. doi:10.1136/gut.2004.042911 [Abstract] [Full text] [PDF] [Request Permissions]
	Hepatitis C virus replicates in peripheral blood mononuclear cells of patients with occult hepatitis C virus infection I Castillo, E Rodríguez-Iñigo, J Bartolomé, S de Lucas, N Ortíz-Movilla, J M López-Alcorocho, M Pardo, and V Carreño Gut 2005; 54: 682-685. doi:10.1136/gut.2004.057281 [Abstract] [Full text] [PDF] [Request Permissions]
	Age and paracetamol self-poisoning L E Schmidt Gut 2005; 54: 686-690. doi:10.1136/gut.2004.054619 [Abstract] [Full text] [PDF] [Request Permissions]
	Splanchnic vein thrombosis in candidates for liver transplantation: usefulness of screening and anticoagulation C Francoz, J Belghiti, V Vilgrain, D Sommacale, V Paradis, B Condat, M H Denninger, A Sauvanet, D Valla, and F Durand Gut 2005; 54: 691-697. doi:10.1136/gut.2004.042796 [Abstract] [Full text] [PDF] [Request Permissions]
	Extrahepatic biliary obstruction after percutaneous tumour ablation for hepatocellular carcinoma: aetiology and successful treatment with endoscopic papillary balloon dilatation N Sasahira, M Tada, H Yoshida, R Tateishi, S Shiina, K Hirano, H Isayama, N Toda, Y Komatsu, T Kawabe, and M Omata Gut 2005; 54: 698-702. doi:10.1136/gut.2003.038331 [Abstract] [Full text] [PDF] [Request Permissions]

Pancreas

Antibodies to carbonic anhydrase and IgG4 levels in idiopathic chronic pancreatitis: relevance for diagnosis of autoimmune pancreatitis L Aparisi, A Farre, L Gomez-Cambronero, J Martinez, G De Las Heras, J Corts, S Navarro, J Mora, M Lopez-Hoyos, L Sabater, A Ferrandez, D Bautista, M Perez-Mateo, S Mery, and J Sastre Gut 2005; 54: 703-709. doi:10.1136/gut.2004.047142 [Abstract] [Full text] [PDF] [Request Permissions]

Recent advances in basic science

	Epidemiology of gastro-oesophageal reflux disease: a systematic review J Dent, H B El-Serag, M-A Wallander, and S Johansson Gut 2005; 54: 710-717. doi:10.1136/gut.2004.051821 [Extract] [Full text] [Competing interest statement] [PDF] [Request Permissions]

Recent advances in clinical practice

	Sepsis in cirrhosis: report on the 7th meeting of the International Ascites Club F Wong, M Bernardi, R Balk, B Christman, R Moreau, G Garcia-Tsao, D Patch, G Soriano, J Hoefs, M Navasa on behalf of the International Ascites Club Gut 2005; 54: 718-725. doi:10.1136/gut.2004.038679 [Extract] [Full text] [PDF] [Request Permissions]

JournalScan

	JournalScan Gut 2005; 54: 726. [Extract] [Full text] [PDF] [Request Permissions]

Letters

	Efficacy and strategy of pneumatic dilatation in achalasia • Authors’ reply R Penagini, P Cantù, and V F Eckardt Gut 2005; 54: 727. [Extract] [Full text] [PDF] [Request Permissions]
	Probiotics in IBD: mucosal and systemic routes of administration may promote similar effects B Foligné, C Grangette, and B Pot Gut 2005; 54: 727-728. [Extract] [Full text] [PDF] [Request Permissions]
	Mutations in anionic trypsinogen gene are not associated with tropical calcific pancreatitis M M Idris, S Bhaskar, D N Reddy, K R Mani, G V Rao, L Singh, and G R Chandak Gut 2005; 54: 728-729. doi:10.1136/gut.2004.055335 [Extract] [Full text] [PDF] [Request Permissions]
	Elevated plasma protein C levels correlate with the presence of fatty liver (NASH and NAFLD) N Assy, S Schlesinger, and O Hussein Gut 2005; 54: 729. doi:10.1136/gut.2004.060251 [Extract] [Full text] [PDF] [Request Permissions]
	Coexistent chronic idiopathic intestinal pseudo obstruction and inflammatory bowel disease B Ohlsson, F-T Fork, B Veress, and E Toth Gut 2005; 54: 729-730. doi:10.1136/gut.2004.058826 [Extract] [Full text] [PDF] [Request Permissions]
	Cannabinoid hyperemesis: not just a problem in Adelaide Hills E Roche and P N Foster Gut 2005; 54: 731. [Extract] [Full text] [PDF] [Request Permissions]
	Inflammatory bowel disease stimulates formation of carcinogenic N-nitroso compounds T M C M de Kok, L G J B Engels, E J Moonen, and J C S Kleinjans Gut 2005; 54: 731. doi:10.1136/gut.2004.057471 [Extract] [Full text] [PDF] [Request Permissions]
	Hepatocellular carcinoma occurring after successful treatment of childhood cancer with high dose chemotherapy and radiation T F Greten, M P Manns, I Reinisch, and P Kaatsch Gut 2005; 54: 732. doi:10.1136/gut.2004.059352 [Extract] [Full text] [PDF] [Request Permissions]
	Biologics in inflammatory disease: infliximab associated risk of lymphoma development C Bucher, L Degen, S Dirnhofer, M Pless, R Herrmann, P Schraml, and P Went Gut 2005; 54: 732-733. [Extract] [Full text] [PDF] [Request Permissions]
	Genotypes 677TT and 677CT+1298AC of methylenetetrahydrofolate reductase are associated with the severity of ulcerative colitis in central China M Chen, B Xia, R M Rodriguez-Gueant, M Bigard, and J-L Gueant Gut 2005; 54: 733-734. doi:10.1136/gut.2004.062539 [Extract] [Full text] [PDF] [Request Permissions]

Corrections

	CORRECTION Gut 2005; 54: 734. doi:10.1136/gut.2004.045294corr1 [Extract] [Full text] [PDF] [Request Permissions]