Leading articles

	Colorectal cancer prognosis: is it all mutation, mutation, mutation? A B Hassan and C Paraskeva Gut 2005; 54: 1209-1211. doi:10.1136/gut.2005.070946 [Abstract] [Full text] [PDF] [Request Permissions]

Digest

	Digest Robin Spiller Gut 2005; 54: 1209. [Extract] [Full text] [PDF] [Request Permissions]

Commentaries

	ASCA: genetic marker, predictor of disease, or marker of a response to an environmental antigen? F Seibold Gut 2005; 54: 1212-1213. doi:10.1136/gut.2005.065227 [Extract] [Full text] [PDF] [Request Permissions]
	Osteopontin: a new addition to the constellation of cytokines which drive T helper cell type 1 responses in Crohn’s disease J N Gordon and T T MacDonald Gut 2005; 54: 1213-1215. doi:10.1136/gut.2004.063412 [Extract] [Full text] [PDF] [Request Permissions]
	Silencing RNA: a novel treatment for pancreatic cancer? N R Lemoine Gut 2005; 54: 1215-1216. doi:10.1136/gut.2005.067108 [Extract] [Full text] [PDF] [Request Permissions]

Small intestine

	T cells in peripheral blood after gluten challenge in coeliac disease R P Anderson, D A van Heel, J A Tye-Din, M Barnardo, M Salio, D P Jewell, and A V S Hill Gut 2005; 54: 1217-1223. doi:10.1136/gut.2004.059998 [Abstract] [Full text] [Competing interest statement] [PDF] [Request Permissions]
	Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant glucagon-like peptide 2 analogue, improves intestinal function in short bowel syndrome patients P B Jeppesen, E L Sanguinetti, A Buchman, L Howard, J S Scolapio, T R Ziegler, J Gregory, K A Tappenden, J Holst, and P B Mortensen Gut 2005; 54: 1224-1231. doi:10.1136/gut.2004.061440 [Abstract] [Full text] [Competing interest statement] [PDF] [Request Permissions]

Inflammatory bowel disease

	Anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic antibodies as predictors of inflammatory bowel disease E Israeli, I Grotto, B Gilburd, R D Balicer, E Goldin, A Wiik, and Y Shoenfeld Gut 2005; 54: 1232-1236. doi:10.1136/gut.2004.060228 [Abstract] [Full text] [PDF] [Request Permissions]
	Anti-Saccharomyces cerevisiae antibodies in twins with inflammatory bowel disease J Halfvarson, A Standaert-Vitse, G Järnerot, B Sendid, T Jouault, L Bodin, A Duhamel, J F Colombel, C Tysk, and D Poulain Gut 2005; 54: 1237-1243. [Abstract] [Full text] [PDF] [Request Permissions]   Published Online First: 29 April 2005. doi:10.1136/gut.2005.066860
	Anti-inflammatory effects of pancreatitis associated protein in inflammatory bowel disease M Gironella, J L Iovanna, M Sans, F Gil, M Peñalva, D Closa, R Miquel, J M Piqué, and J Panés Gut 2005; 54: 1244-1253. [Abstract] [Full text] [PDF] [Request Permissions]   Published Online First: 3 May 2005. doi:10.1136/gut.2004.056309
	Osteopontin/Eta-1 upregulated in Crohn’s disease regulates the Th1 immune response T Sato, T Nakai, N Tamura, S Okamoto, K Matsuoka, A Sakuraba, T Fukushima, T Uede, and T Hibi Gut 2005; 54: 1254-1262. doi:10.1136/gut.2004.048298 [Abstract] [Full text] [PDF] [Request Permissions]

Miscellanea

	An exceptional cause for recurrent vomiting K Honein, J Boujaoude, M Chemaly, C Tohme, and B Abboud Gut 2005; 54: 1262. doi:10.1136/gut.2004.062893 [Extract] [Full text] [PDF] [Request Permissions]
	An unusual case of hepatosplenomegaly D Joshi, J Dunga, A James, and M M Yaqoob Gut 2005; 54: 1272. doi:10.1136/gut.2005.064824 [Extract] [Full text] [PDF] [Request Permissions]
	A challenging presentation of left upper quadrant pain R Taghizadeh, B K Chew, and K G Mitchell Gut 2005; 54: 1278. doi:10.1136/gut.2004.059063 [Extract] [Full text] [PDF] [Request Permissions]
	A case of progressive dysphagia G S Sica, V Sujendran, B Warren, and N D Maynard Gut 2005; 54: 1282. doi:10.1136/gut.2004.063297 [Extract] [Full text] [PDF] [Request Permissions]
	Answer Gut 2005; 54: 1292. [Extract] [Full text] [PDF] [Request Permissions]
	Answer Gut 2005; 54: 1308. [Extract] [Full text] [PDF] [Request Permissions]
	Answer Gut 2005; 54: 1317. [Extract] [Full text] [PDF] [Request Permissions]
	Answer Gut 2005; 54: 1331. [Extract] [Full text] [PDF] [Request Permissions]

Anorectal disease

	Rectal sensorimotor dysfunction in patients with urge faecal incontinence: evidence from prolonged manometric studies C L H Chan, P J Lunniss, D Wang, N S Williams, and S M Scott Gut 2005; 54: 1263-1272. [Abstract] [Full text] [PDF] [Request Permissions]   Published Online First: 24 May 2005. doi:10.1136/gut.2005.071613

Colorectal cancer

	Incomplete screening flexible sigmoidoscopy associated with female sex, age, and increased risk of colorectal cancer V P Doria-Rose, P A Newcomb, and T R Levin Gut 2005; 54: 1273-1278. [Abstract] [Full text] [PDF] [Request Permissions]   Published Online First: 4 May 2005. doi:10.1136/gut.2005.064030
	Fordyce granules and hereditary non-polyposis colorectal cancer syndrome C De Felice, S Parrini, G Chitano, M Gentile, L Dipaola, and G Latini Gut 2005; 54: 1279-1282. [Abstract] [Full text] [PDF] [Request Permissions]   Published Online First: 6 May 2005. doi:10.1136/gut.2005.064881
	The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma A Conlin, G Smith, F A Carey, C R Wolf, and R J C Steele Gut 2005; 54: 1283-1286. [Abstract] [Full text] [PDF] [Request Permissions]   Published Online First: 20 April 2005. doi:10.1136/gut.2005.066514
	Methylation of the oestrogen receptor gene in non-neoplastic epithelium as a marker of colorectal neoplasia risk in longstanding and extensive ulcerative colitis S Fujii, K Tominaga, K Kitajima, J Takeda, T Kusaka, M Fujita, K Ichikawa, S Tomita, Y Ohkura, Y Ono, J Imura, T Chiba, and T Fujimori Gut 2005; 54: 1287-1292. [Abstract] [Full text] [PDF] [Request Permissions]   Published Online First: 3 May 2005. doi:10.1136/gut.2004.062059

Pancreatitis

	Detection and identification of bacterial DNA in serum from patients with acute pancreatitis E de Madaria, J Martínez, B Lozano, L Sempere, S Benlloch, J Such, F Uceda, R Francés, and M Pérez-Mateo Gut 2005; 54: 1293-1297. doi:10.1136/gut.2004.047514 [Abstract] [Full text] [PDF] [Request Permissions]

Pancreatic cancer

	Variants of bcl-2 specific siRNA for silencing antiapoptotic bcl-2 in pancreatic cancer M Ocker, D Neureiter, M Lueders, S Zopf, M Ganslmayer, E G Hahn, C Herold, and D Schuppan Gut 2005; 54: 1298-1308. doi:10.1136/gut.2004.056192 [Abstract] [Full text] [PDF] [Request Permissions]

Hepatitis

	CREB/PKA sensitive signalling pathways activate and maintain expression levels of the hepatitis B virus pre-S2/S promoter F Tacke, C Liedtke, S Bocklage, M P Manns, and C Trautwein Gut 2005; 54: 1309-1317. [Abstract] [Full text] [PDF] [Request Permissions]   Published Online First: 4 May 2005. doi:10.1136/gut.2005.065086

Case reports

	p53 gene (Gendicine) and embolisation overcame recurrent hepatocellular carcinoma Y S Guan, Y Liu, X P Zhou, X Li, Q He, and L Sun Gut 2005; 54: 1318-1319. [Abstract] [Full text] [PDF] [Request Permissions]   Published Online First: 5 May 2005. doi:10.1136/gut.2005.069237

JournalScan

	JournalScan Gut 2005; 54: 1320. [Extract] [Full text] [PDF] [Request Permissions]

Recent advances in basic science

	INFECTION, INFLAMMATION, AND GASTROINTESTINAL CANCER C R Boland, M G Luciani, C Gasche, and A Goel Gut 2005; 54: 1321-1331. doi:10.1136/gut.2004.060079 [Extract] [Full text] [PDF] [Request Permissions]

Recent advances in clinical practice

	USE OF PSYCHOPHARMACOLOGICAL AGENTS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS R E Clouse and P J Lustman Gut 2005; 54: 1332-1341. doi:10.1136/gut.2004.048884 [Extract] [Full text] [PDF] [Request Permissions]

Letters

	Novel presentation of coeliac disease after following the Atkins’ low carbohydrate diet D A van Heel, J Dart, S Nichols, D P Jewell, and R J Playford Gut 2005; 54: 1342. doi:10.1136/gut.2004.062588 [Extract] [Full text] [PDF] [Request Permissions]
	Cap polyposis: an inflammatory disorder or a spectrum of mucosal prolapse syndrome? T Konishi, T Watanabe, Y Takei, T Kojima, and H Nagawa Gut 2005; 54: 1342-1343. doi:10.1136/gut.2005.073452 [Extract] [Full text] [PDF] [Request Permissions]
	Chronic intestinal pseudo-obstruction due to lymphocytic leiomyositis: is there a place for immunomodulatory therapy? E Oton, V Moreira, C Redondo, A Lopez-San-Roman, J R Foruny, G Plaza, E de Vicente, and Y Quijano Gut 2005; 54: 1343-1344. doi:10.1136/gut.2005.071811 [Extract] [Full text] [PDF] [Request Permissions]
	UK guidelines for management of acute pancreatitis: is it time to change? K S Gurusamy, M Farouk, and J H Tweedie Gut 2005; 54: 1344-1345. doi:10.1136/gut.2005.071076 [Extract] [Full text] [PDF] [Request Permissions]
	RANK ligand and osteoprotegerin: emerging roles in mucosal inflammation A J Ashcroft and S R Carding Gut 2005; 54: 1345-1346. doi:10.1136/gut.2005.070623 [Extract] [Full text] [PDF] [Request Permissions]
	Synbiotic therapy for ulcerative colitis J E D Mawdsley, J Lindsay, and D Rampton Gut 2005; 54: 1346. doi:10.1136/gut.2005.070599 [Extract] [Full text] [PDF] [Request Permissions]
	Deranged smooth muscle -actin expression as a biomarker of intestinal pseudo-obstruction E Jaynes, N J Carr, and A C Bateman Gut 2005; 54: 1346. doi:10.1136/gut.2004.062307 [Extract] [Full text] [PDF] [Request Permissions]
	Inflammatory biomarkers predict relapse in IBD P Hanaway and A Roseth Gut 2005; 54: 1346-1347. doi:10.1136/gut.2005.070615 [Extract] [Full text] [Competing interest statement] [PDF] [Request Permissions]
	Colitis evolving into ulcerative colitis C Calabrese, A Fabbri, and G di Febo Gut 2005; 54: 1347-1348. doi:10.1136/gut.2005.065763 [Extract] [Full text] [PDF] [Request Permissions]
	Is there an ideal prognostic model for hepatocellular carcinoma? T-I Huo, Y-H Huang, S-D Lee, and J-C Wu Gut 2005; 54: 1348. doi:10.1136/gut.2005.069468 [Extract] [Full text] [PDF] [Request Permissions]
	Response to steroid therapy of sclerosing cholangitis after duodenopancreatectomy due to autoimmune pancreatitis D Padilla, T Cubo, P Villarejo, R Pardo, A Jara, R de la Plaza, and J Hernández Gut 2005; 54: 1348-1349. doi:10.1136/gut.2005.070672 [Extract] [Full text] [PDF] [Request Permissions]
	Calprotectin and IBD • Author’s reply M Lemann, J Y Mary, M Bottai, F Costa, and M G Mumolo Gut 2005; 54: 1349-1350. doi:10.1136/gut.2005.070656 [Extract] [Full text] [PDF] [Request Permissions]

Book reviews

	Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas J J Boyle Gut 2005; 54: 1350. doi:10.1136/gut.2005.068221 [Extract] [Full text] [PDF] [Request Permissions]
	The Inflammatory Bowel Disease Yearbook 2004 S Ghosh Gut 2005; 54: 1350. doi:10.1136/gut.2005.066712 [Extract] [Full text] [PDF] [Request Permissions]