Digest:

Digest

Robin Spiller and Magnus Simren

Gut 2009; 58: i-ii.

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Leading articles:

Elastography for the non-invasive assessment of liver disease: limitations and future developments

Francesco Vizzutti, Umberto Arena, Fabio Marra, and Massimo Pinzani

Gut 2009; 58: 157-160. doi:10.1136/gut.2008.156489

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Editor's quiz:

When gastroenterology meets dermatology

G E Gurvits and J G Robilotti

Gut 2009; 58: 160. doi:10.1136/gut.2008.162610

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A rare diagnosis of pancreatic tumour

C-S Chung, W-C Liao, and H-P Wang

Gut 2009; 58: 188. doi:10.1136/gut.2008.164285

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Very large gastric ulcer with a round lesion

Y Tatsumi, K Inoue, H Kanemasa, A Toma, K Tsukamoto, and Y Kajita

Gut 2009; 58: 232. doi:10.1136/gut.2008.159921

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Commentaries:

Impaired intestinal molecular tightness in the mucosa of irritable bowel syndrome: what are the mediators?

Maria Vicario, Carmen Alonso, and Javier Santos

Gut 2009; 58: 161-162. doi:10.1136/gut.2008.165670

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Chromosomal instability and cancer: not just one CINgle mechanism

C Richard Boland, Natalia L Komarova, and Ajay Goel

Gut 2009; 58: 163-164. doi:10.1136/gut.2008.160143

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Neuroendocrine tumours: a hope and a prayer

Ashley Grossman

Gut 2009; 58: 164-165. doi:10.1136/gut.2008.164640

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Oesophageal disease:

FGF9-induced proliferative response to eosinophilic inflammation in oesophagitis

D J Mulder, I Pacheco, D J Hurlbut, N Mak, G T Furuta, R J MacLeod, and C J Justinich

Gut 2009; 58: 166-173.
Published Online First: 31 October 2008. doi:10.1136/gut.2008.157628

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The effect of metabolic risk factors on the natural course of gastro-oesophageal reflux disease

Y-C Lee, A M-F Yen, J J Tai, S-H Chang, J-T Lin, H-M Chiu, H-P Wang, M-S Wu, and T H-H Chen

Gut 2009; 58: 174-181.
Published Online First: 20 October 2008. doi:10.1136/gut.2008.162305

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Race, ethnicity, sex and temporal differences in Barrett’s oesophagus diagnosis: a large community-based study, 1994–2006

D A Corley, A Kubo, T R Levin, G Block, L Habel, G Rumore, C Quesenberry, and P Buffler

Gut 2009; 58: 182-188.
Published Online First: 31 October 2008. doi:10.1136/gut.2008.163360

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Coeliac disease:

Aberrant extrathymic T cell receptor gene rearrangement in the small intestinal mucosa: a risk factor for coeliac disease?

A Bas, G Forsberg, V Sjöberg, S Hammarström, O Hernell, and M-L Hammarström

Gut 2009; 58: 189-195.
Published Online First: 25 February 2008. doi:10.1136/gut.2007.125526

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Neurogastroenterology:

Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators

T Piche, G Barbara, P Aubert, S Bruley des Varannes, R Dainese, J L Nano, C Cremon, V Stanghellini, R De Giorgio, J P Galmiche, and M Neunlist

Gut 2009; 58: 196-201.
Published Online First: 29 September 2008. doi:10.1136/gut.2007.140806

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Reciprocal changes in vanilloid (TRPV1) and endocannabinoid (CB1) receptors contribute to visceral hyperalgesia in the water avoidance stressed rat

S Hong, J Fan, E S Kemmerer, S Evans, Y Li, and J W Wiley

Gut 2009; 58: 202-210.
Published Online First: 20 October 2008. doi:10.1136/gut.2008.157594

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Inflammatory bowel disease:

CD4⁺Foxp3⁺ regulatory T cell expansion induced by antigen-driven interaction with intestinal epithelial cells independent of local dendritic cells

A M Westendorf, D Fleissner, L Groebe, S Jung, A D Gruber, W Hansen, and J Buer

Gut 2009; 58: 211-219.
Published Online First: 2 October 2008. doi:10.1136/gut.2008.151720

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Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients

H-J Epple, T Schneider, H Troeger, D Kunkel, K Allers, V Moos, M Amasheh, C Loddenkemper, M Fromm, M Zeitz, and J-D Schulzke

Gut 2009; 58: 220-227.
Published Online First: 20 October 2008. doi:10.1136/gut.2008.150425

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Positive association of genetic variants in the upstream region of NKX2-3 with Crohn’s disease in Japanese patients

K Yamazaki, A Takahashi, M Takazoe, M Kubo, Y Onouchi, A Fujino, N Kamatani, Y Nakamura, and A Hata

Gut 2009; 58: 228-232.
Published Online First: 20 October 2008. doi:10.1136/gut.2007.140764

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Once daily versus three times daily mesalazine granules in active ulcerative colitis: a double-blind, double-dummy, randomised, non-inferiority trial

W Kruis, G Kiudelis, I Rácz, I A Gorelov, J Pokrotnieks, M Horynski, M Batovsky, J Kykal, S Boehm, R Greinwald, R Mueller on behalf of the International Salofalk OD Study Group

Gut 2009; 58: 233-240.
Published Online First: 2 October 2008. doi:10.1136/gut.2008.154302

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Colonic cancer:

Comparison of CT colonography, colonoscopy, sigmoidoscopy and faecal occult blood tests for the detection of advanced adenoma in an average risk population

A Graser, P Stieber, D Nagel, C Schäfer, D Horst, C R Becker, K Nikolaou, A Lottes, S Geisbüsch, H Kramer, A C Wagner, H Diepolder, J Schirra, H J Roth, D Seidel, B Göke, M F Reiser, and F T Kolligs

Gut 2009; 58: 241-248.
Published Online First: 13 October 2008. doi:10.1136/gut.2008.156448

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Human Sgo1 downregulation leads to chromosomal instability in colorectal cancer

M Iwaizumi, K Shinmura, H Mori, H Yamada, M Suzuki, Y Kitayama, H Igarashi, T Nakamura, H Suzuki, Y Watanabe, A Hishida, M Ikuma, and H Sugimura

Gut 2009; 58: 249-260.
Published Online First: 17 July 2008. doi:10.1136/gut.2008.149468

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Editor's quiz: GI snapshot:

ANSWER

Gut 2009; 58: 248. doi:10.1136/gut.2008.164285a

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ANSWER

Gut 2009; 58: 293. doi:10.1136/gut.2008.159921a

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ANSWER

Gut 2009; 58: 310. doi:10.1136/gut.2008.162610a

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Pancreatic disease:

The oral multitarget tumour growth inhibitor, ZK 304709, inhibits growth of pancreatic neuroendocrine tumours in an orthotopic mouse model

A Scholz, K Wagner, M Welzel, F Remlinger, B Wiedenmann, G Siemeister, S Rosewicz, and K M Detjen

Gut 2009; 58: 261-270.
Published Online First: 1 October 2008. doi:10.1136/gut.2007.146415

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Ezrin interacts with cortactin to form podosomal rosettes in pancreatic cancer cells

H M Kocher, J Sandle, T A Mirza, N F Li, and I R Hart

Gut 2009; 58: 271-284.
Published Online First: 13 October 2008. doi:10.1136/gut.2008.159871

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Hepatology:

Vascular endothelial growth factor and angiopoietin-2 play a major role in the pathogenesis of vascular leakage in cirrhotic rats

P Melgar-Lesmes, S Tugues, J Ros, G Fernández-Varo, M Morales-Ruiz, J Rodés, and W Jiménez

Gut 2009; 58: 285-292.
Published Online First: 31 October 2008. doi:10.1136/gut.2008.155028

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JournalScan:

JournalScan

Gut 2009; 58: 294.

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Recent advances in clinical practice:

Management of heartburn not responding to proton pump inhibitors

R Fass and D Sifrim

Gut 2009; 58: 295-309. doi:10.1136/gut.2007.145581

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PostScript:

Rectal cancer surgery: is restoration of intestinal continuity the primary aim?

C R Selvasekar, G David, D J Corless, A U Khan, and J P Slavin

Gut 2009; 58: 311.

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Authors’ response

E Morris, P Quirke, J Thomas, L Fairley, B Cottier, and D Forman

Gut 2009; 58: 311-312.

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Increased ergothioneine tissue concentrations in carriers of the Crohn’s disease risk-associated 503F variant of the organic cation transporter OCTN1

D Taubert, N Jung, T Goeser, and E Schömig

Gut 2009; 58: 312-314. doi:10.1136/gut.2008.164418

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Pegylated interferon -2a plus low-dose ribavirin for the retreatment of dialysis chronic hepatitis C patients who relapsed from prior interferon monotherapy

C-H Liu, C-C Liang, C-J Liu, H-B Tsai, P-H Hung, S-J Hsu, S-I Chen, J-W Lin, M-Y Lai, J-H Chen, P-J Chen, D-S Chen, and J-H Kao

Gut 2009; 58: 314-316. doi:10.1136/gut.2008.165076

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CORRECTION

Gut 2009; 58: 316.

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