Digest:

Digest

Robin Spiller and Magnus Simren

Gut 2009; 58: i-ii.

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Leading articles:

Isotretinoin and intestinal inflammation: what gastroenterologists need to know

Matthew Shale, Gilaad G Kaplan, Remo Panaccione, and Subrata Ghosh

Gut 2009; 58: 737-741. doi:10.1136/gut.2008.170530

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Editor's quiz:

Ileal obstruction in a 73-year-old woman

C-H Tseng, W-L Wang, T-C Lee, T-H Lee, and H-P Wang

Gut 2009; 58: 741. doi:10.1136/gut.2008.164913

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In disguise as an acute flare: an unusual differential diagnosis of Crohn’s disease

J G Albert, F S Gittinger, M Hainz, and C Lübbert

Gut 2009; 58: 742. doi:10.1136/gut.2008.167874

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A case of persistent vomiting

A Pang, P L Chia, B Ang, S A Buhari, and B Y S Chuah

Gut 2009; 58: 750. doi:10.1136/gut.2008.167643

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ANSWER

Gut 2009; 58: 770. doi:10.1136/gut.2008.167643a

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ANSWER

Gut 2009; 58: 804. doi:10.1136/gut.2008.164913a

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A tenacious complete small bowel obstruction

S Di Saverio, G Tugnoli, F Catena, A Biscardi, and F Baldoni

Gut 2009; 58: 812. doi:10.1136/gut.2008.171660

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ANSWER

Gut 2009; 58: 832. doi:10.1136/gut.2008.167874a

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ANSWER

Gut 2009; 58: 891-892. doi:10.1136/gut.2008.171660a

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Commentaries:

Critical role for CD8⁺FoxP3⁺ regulatory T cells in colon cancer immune response in humans

Iradj Sobhani and Sabine Le Gouvello

Gut 2009; 58: 743-744. doi:10.1136/gut.2008.175521

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Role of hydrogen sulfide in visceral nociception

Michael Schemann and David Grundy

Gut 2009; 58: 744-747. doi:10.1136/gut.2008.167858

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Selective targeting of activated T cells in chronic intestinal inflammation

Benno Weigmann and Markus F Neurath

Gut 2009; 58: 747-748. doi:10.1136/gut.2008.170183

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Variations in trypsinogen expression may influence the protective effect of the p.G191R PRSS2 variant in chronic pancreatitis

Frank Ulrich Weiss and Miklós Sahin-Tóth

Gut 2009; 58: 749-750. doi:10.1136/gut.2008.173039

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Neurogastroenterology:

Luminal hydrogen sulfide plays a pronociceptive role in mouse colon

M Matsunami, T Tarui, K Mitani, K Nagasawa, O Fukushima, K Okubo, S Yoshida, M Takemura, and A Kawabata

Gut 2009; 58: 751-761.
Published Online First: 13 October 2008. doi:10.1136/gut.2007.144543

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Hydrogen sulfide as a novel mediator for pancreatic pain in rodents

S Nishimura, O Fukushima, H Ishikura, T Takahashi, M Matsunami, T Tsujiuchi, F Sekiguchi, M Naruse, Y Kamanaka, and A Kawabata

Gut 2009; 58: 762-770.
Published Online First: 6 February 2009. doi:10.1136/gut.2008.151910

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Intestinal inflammation:

Toll-like receptor 2 is critical for induction of Reg3β expression and intestinal clearance of Yersinia pseudotuberculosis

R Dessein, M Gironella, C Vignal, L Peyrin-Biroulet, H Sokol, T Secher, S Lacas-Gervais, J-J Gratadoux, F Lafont, J-C Dagorn, B Ryffel, S Akira, P Langella, G Nùñez, J-C Sirard, J Iovanna, M Simonet, and M Chamaillard

Gut 2009; 58: 771-776.
Published Online First: 27 January 2009. doi:10.1136/gut.2008.168443

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Inflammatory bowel disease:

Transforming growth factor β signalling and matrix metalloproteinases in the mucosa overlying Crohn’s disease strictures

A Di Sabatino, C L Jackson, K M Pickard, M Buckley, L Rovedatti, N A B Leakey, L Picariello, P Cazzola, G Monteleone, F Tonelli, G R Corazza, T T MacDonald, and S L Pender

Gut 2009; 58: 777-789.
Published Online First: 6 February 2009. doi:10.1136/gut.2008.149096

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Therapeutic potency of IL2–caspase 3 targeted treatment in a murine experimental model of inflammatory bowel disease

S Shteingart, M Rapoport, I Grodzovski, O Sabag, M Lichtenstein, R Eavri, and H Lorberboum-Galski

Gut 2009; 58: 790-798.
Published Online First: 31 October 2008. doi:10.1136/gut.2008.153981

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Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis

E A M Festen, P Goyette, R Scott, V Annese, A Zhernakova, J Lian, C Lefèbvre, S R Brant, J H Cho, M S Silverberg, K D Taylor, D J de Jong, P C Stokkers, D Mcgovern, O Palmieri, J-P Achkar, R J Xavier, M J Daly, R H Duerr, C Wijmenga, R K Weersma, and J D Rioux

Gut 2009; 58: 799-804.
Published Online First: 6 February 2009. doi:10.1136/gut.2008.166918

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Colorectal cancer:

Methylenetetrahydrofolate reductase deficiency and low dietary folate reduce tumorigenesis in Apc^min/+ mice

A K Lawrance, L Deng, and R Rozen

Gut 2009; 58: 805-811.
Published Online First: 27 January 2009. doi:10.1136/gut.2007.143107

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Pancreas:

Impact of toll-like receptor 4 on the severity of acute pancreatitis and pancreatitis-associated lung injury in mice

R Sharif, R Dawra, K Wasiluk, P Phillips, V Dudeja, E Kurt-Jones, R Finberg, and A Saluja

Gut 2009; 58: 813-819.
Published Online First: 6 February 2009. doi:10.1136/gut.2008.170423

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A loss-of-function p.G191R variant in the anionic trypsinogen (PRSS2) gene in Japanese patients with pancreatic disorders

K Kume, A Masamune, Y Takagi, K Kikuta, T Watanabe, K Satoh, A Satoh, M Hirota, S Hamada, and T Shimosegawa

Gut 2009; 58: 820-824.
Published Online First: 3 December 2008. doi:10.1136/gut.2008.151688

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Hepatology:

Serum proteomic profiling of obese patients: correlation with liver pathology and evolution after bariatric surgery

V Trak-Smayra, D Dargere, R Noun, M Albuquerque, C Yaghi, M-H Gannagé-Yared, P Bedossa, and V Paradis

Gut 2009; 58: 825-832.
Published Online First: 10 April 2008. doi:10.1136/gut.2007.140087

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Plasma proteasome level is a reliable early marker of malignant transformation of liver cirrhosis

L Henry, T Lavabre-Bertrand, L Vercambre, J Ramos, S Carillo, I Guiraud, P Pouderoux, M Bismuth, J-C Valats, C Demattei, Y Duny, I Chaze, N Funakoshi, J P Bureau, J-P Daurès, and P Blanc

Gut 2009; 58: 833-838.
Published Online First: 6 February 2009. doi:10.1136/gut.2008.157016

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Visceral fat accumulation is an independent risk factor for hepatocellular carcinoma recurrence after curative treatment in patients with suspected NASH

T Ohki, R Tateishi, S Shiina, E Goto, T Sato, H Nakagawa, R Masuzaki, T Goto, K Hamamura, F Kanai, H Yoshida, T Kawabe, and M Omata

Gut 2009; 58: 839-844.
Published Online First: 27 January 2009. doi:10.1136/gut.2008.164053

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JournalScan:

JournalScan

Gut 2009; 58: 845.

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Recent advances in basic science:

Gene expression and hepatitis C virus infection

T Asselah, I Bièche, A Sabbagh, P Bedossa, R Moreau, D Valla, M Vidaud, and P Marcellin

Gut 2009; 58: 846-858.
Published Online First: 11 December 2008. doi:10.1136/gut.2008.166348

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Recent advances in clinical practice:

Monitoring disease activity by stool analyses: from occult blood to molecular markers of intestinal inflammation and damage

D Foell, H Wittkowski, and J Roth

Gut 2009; 58: 859-868.
Published Online First: 9 January 2009. doi:10.1136/gut.2008.170019

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Guidelines:

Antibiotic prophylaxis in gastrointestinal endoscopy

M C Allison, J A T Sandoe, R Tighe, I A Simpson, R J Hall, T S J Elliott prepared on behalf of the Endoscopy Committee of the British Society of Gastroenterology

Gut 2009; 58: 869-880. doi:10.1136/gut.2007.136580

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PostScript:

The G191R variant in the PRSS2 gene does not play a role in protection against tropical calcific pancreatitis

S Mahurkar, S Bhaskar, D N Reddy, G V Rao, S P Singh, V Thomas, and G R Chandak

Gut 2009; 58: 881-882. doi:10.1136/gut.2008.170753

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Decreased Paneth cell defensin expression in ileal Crohn’s disease is independent of inflammation, but linked to the NOD2 1007fs genotype

C L Bevins, E F Stange, and J Wehkamp

Gut 2009; 58: 882-883.

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Authors' reply

L A Simms, J D Doecke, and G L Radford-Smith

Gut 2009; 58: 883-884.

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Clarification

J Wehkamp, C L Bevins, and E F Stange

Gut 2009; 58: 884.

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Association and differential role of PRSS1 and SPINK1 mutation in early-onset and late-onset idiopathic chronic pancreatitis in Chinese subjects

Y-T Chang, S-C Wei, P-C L, Y-W Tien, I-S Jan, Y-N Su, J-M Wong, and M-C Chang

Gut 2009; 58: 885. doi:10.1136/gut.2007.129916

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Is it true that coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa

D Bernardo, J A Garrote, I Nadal, A J León, C Calvo, L Fernández-Salazar, A Blanco-Quirós, Y Sanz, and E Arranz

Gut 2009; 58: 886-887. doi:10.1136/gut.2008.167296

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Data selection flaw

R J L F Loffeld

Gut 2009; 58: 887.

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Authors’ response

M W Lutgens, B Oldenburg, and F P Vleggaar

Gut 2009; 58: 887.

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Needle-track seeding following biopsy of liver lesions in the diagnosis of hepatocellular cancer: a systematic review and meta-analysis

A L Young and J P A Lodge

Gut 2009; 58: 887-888.

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A possible link between TIMP-1 induction and response to infliximab

S Derer, G H Waetzig, D Seegert, S Nikolaus, S Schreiber, and P Rosenstiel

Gut 2009; 58: 888.

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Authors’ response

J M H Van den Brande, D W Hommes, and M P Peppelenbosch

Gut 2009; 58: 888-889.

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Incidence and prevalence rates in Budd–Chiari syndrome

R Rajani and S Almer

Gut 2009; 58: 889.

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Development of ductal adenocarcinoma during follow-up of branch-duct IPMNs

S Crippa, R Salvia, and C Bassi

Gut 2009; 58: 889-890.

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