Digest:

Digest

Gut 2009; 58: i-ii. doi:10.1136/gut.2009.200840

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Editorials:

The year in Gut 2009

Robin Spiller

Gut 2009; 58: 1569-1570. doi:10.1136/gut.2009.200246

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Leader:

Biomarkers in IBS: when will they replace symptoms for diagnosis and management?

Giovanni Barbara and Vincenzo Stanghellini

Gut 2009; 58: 1571-1575. doi:10.1136/gut.2008.169672

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Editor's quiz:

"Too much, too soon"

B Husein, J Iqbal, A Mohammed, and C Shorrock

Gut 2009; 58: 1575. doi:10.1136/gut.2008.175174

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An unusual cause of obscure gastrointestinal bleeding

C-M Tai, H-P Wang, J-C Hwang, T-C Lee, C-T Lee, and J-T Lin

Gut 2009; 58: 1605. doi:10.1136/gut.2009.179341

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A patient with new onset of thoracic pain, dyspnoea and weight loss

G Lohr, C Luft, and K Lenz

Gut 2009; 58: 1653. doi:10.1136/gut.2009.178111

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An unusual case of gastric erosions

D K Jothimani, U Zanetto, R J Owen, A J Lawson, and P G Wilson

Gut 2009; 58: 1669. doi:10.1136/gut.2008.176065

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Commentaries:

Adiponectin and JNK: metabolic/inflammatory pathways affecting gastrointestinal carcinogenesis

Herbert Tilg and Arthur Kaser

Gut 2009; 58: 1576-1577. doi:10.1136/gut.2009.190959

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Ulcerative colitis: is it in the diet?

Franck Carbonnel and Marie Christine Boutron

Gut 2009; 58: 1577-1579. doi:10.1136/gut.2009.190561

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HIV/hepatitis C co-infection and hepatic fibrosis: looking beyond HIV-associated immune suppression; the contribution of hepatic steatosis and insulin resistance

Sanjay Bhagani

Gut 2009; 58: 1579-1581. doi:10.1136/gut.2009.184473

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Selective inhibition of NF-B in Kupffer cells: good, but not for everything

Fabio Marra

Gut 2009; 58: 1581-1582. doi:10.1136/gut.2009.183400

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Oesophagus:

Association of adiponectin multimers with Barrett’s oesophagus

J H Rubenstein, J Y Kao, R D Madanick, M Zhang, M Wang, M B Spacek, J L Donovan, S D Bright, and N J Shaheen

Gut 2009; 58: 1583-1589.
Published Online First: 30 June 2009. doi:10.1136/gut.2008.171553

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Small intestine:

Role of dietary fibres, intestinal hypermotility and leukotrienes in the pathogenesis of NSAID-induced small intestinal ulcers in cats

H Satoh, S Shiotani, N Otsuka, K Hatao, and S Nishimura

Gut 2009; 58: 1590-1596.
Published Online First: 5 December 2008. doi:10.1136/gut.2008.156596

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Gliadin-primed CD4+CD45RBlowCD25– T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic mice

T L Freitag, S Rietdijk, Y Junker, Y Popov, A K Bhan, C P Kelly, C Terhorst, and D Schuppan

Gut 2009; 58: 1597-1605.
Published Online First: 10 August 2009. doi:10.1136/gut.2009.186361

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Inflammatory bowel disease:

Linoleic acid, a dietary n-6 polyunsaturated fatty acid, and the aetiology of ulcerative colitis: a nested case–control study within a European prospective cohort study

The IBD in EPIC Study Investigators

Gut 2009; 58: 1606-1611.
Published Online First: 23 July 2009. doi:10.1136/gut.2008.169078

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Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitis

I Arijs, K Li, G Toedter, R Quintens, L Van Lommel, K Van Steen, P Leemans, G De Hertogh, K Lemaire, M Ferrante, F Schnitzler, L Thorrez, K Ma, X-Y R Song, C Marano, G Van Assche, S Vermeire, K Geboes, F Schuit, F Baribaud, and P Rutgeerts

Gut 2009; 58: 1612-1619.
Published Online First: 20 August 2009. doi:10.1136/gut.2009.178665

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Identification of GP2, the major zymogen granule membrane glycoprotein, as the autoantigen of pancreatic antibodies in Crohn’s disease

D Roggenbuck, G Hausdorf, L Martinez-Gamboa, D Reinhold, T Büttner, P R Jungblut, T Porstmann, M W Laass, J Henker, C Büning, E Feist, and K Conrad

Gut 2009; 58: 1620-1628.
Published Online First: 22 June 2009. doi:10.1136/gut.2008.162495

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Differential regulation of interleukin 17 and interferon production in inflammatory bowel disease

L Rovedatti, T Kudo, P Biancheri, M Sarra, C H Knowles, D S Rampton, G R Corazza, G Monteleone, A Di Sabatino, and T T MacDonald

Gut 2009; 58: 1629-1636.
Published Online First: 8 September 2009. doi:10.1136/gut.2009.182170

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Colorectal cancer:

Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary conditions

H Endo, K Hosono, T Fujisawa, H Takahashi, M Sugiyama, K Yoneda, Y Nozaki, K Fujita, M Yoneda, M Inamori, K Wada, H Nakagama, and A Nakajima

Gut 2009; 58: 1637-1643.
Published Online First: 30 June 2009. doi:10.1136/gut.2009.183624

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Hepatology:

New aspects of an anti-tumour drug: sorafenib efficiently inhibits HCV replication

K Himmelsbach, D Sauter, T F Baumert, L Ludwig, H E Blum, and E Hildt

Gut 2009; 58: 1644-1653.
Published Online First: 25 August 2009. doi:10.1136/gut.2009.182212

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Insulin resistance is associated with liver stiffness in HIV/HCV co-infected patients

N Merchante, A Rivero, I de los Santos-Gil, D Merino, M Márquez, M Á López-Ruz, J Rodríguez-Baño, J del Valle, Á Camacho, J Sanz-Sanz, J Macías, I Pérez-Camacho, J Gómez-Mateos, A Moro, and J A Pineda

Gut 2009; 58: 1654-1660.
Published Online First: 21 July 2009. doi:10.1136/gut.2009.179085

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Insulin resistance and geographical origin: major predictors of liver fibrosis and response to peginterferon and ribavirin in HCV-4

R Moucari, M-P Ripault, M Martinot-Peignoux, H Voitot, A-C Cardoso, C Stern, N Boyer, S Maylin, M-H Nicolas-Chanoine, M Vidaud, D Valla, P Bedossa, and P Marcellin

Gut 2009; 58: 1662-1669.
Published Online First: 10 August 2009. doi:10.1136/gut.2009.185074

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A novel technique for selective NF-B inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia–reperfusion

F Hoffmann, G Sass, J Zillies, S Zahler, G Tiegs, A Hartkorn, S Fuchs, J Wagner, G Winter, C Coester, A L Gerbes, and A M Vollmar

Gut 2009; 58: 1670-1678.
Published Online First: 25 May 2009. doi:10.1136/gut.2008.165647

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JournalScan:

JournalScan

Guru Aithal

Gut 2009; 58: 1679. doi:10.1136/gut.2009.199307

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Recent advances in basic science:

Recent advances in autoimmune pancreatitis

D H Park, M-H Kim, and S T Chari

Gut 2009; 58: 1680-1689.
Published Online First: 24 February 2009. doi:10.1136/gut.2008.155853

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Recent advances in clinical practice:

Artificial and bioartificial liver devices: present and future

B Carpentier, A Gautier, and C Legallais

Gut 2009; 58: 1690-1702. doi:10.1136/gut.2008.175380

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PostScript:

Long-term safety of Infliximab for the treatment of inflammatory bowel disease: does blocking TNF reduce colitis-associated colorectal carcinogenesis?

L Biancone, C Petruzziello, E Calabrese, F Zorzi, P Naccarato, S Onali, and F Pallone

Gut 2009; 58: 1703. doi:10.1136/gut.2008.176461

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Discordant practice and limited histopathological assessment in gastrointestinal neuromuscular disease

J E Martin, T W Hester, H Aslam, S Sinha, and C H Knowles

Gut 2009; 58: 1703-1705. doi:10.1136/gut.2009.184572

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Interleukin 2 targeted therapy in inflammatory bowel disease

S Yarkoni, Y Sagiv, A Kaminitz, and N Askenasy

Gut 2009; 58: 1705-1706. doi:10.1136/gut.2008.175182

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Haemoglobin and non-alcoholic fatty liver disease: further evidence from a population-based study

L Xu, C-f Xu, C-h Yu, M Miao, and Y-m Li

Gut 2009; 58: 1706-1707. doi:10.1136/gut.2009.186668

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