Abstract
Using the open-field activity of the hooded rat as a model of overall activity, the dose-response and time-action effects of doses of Δ 9-THC which did not adversely affect spontaneous activity or behavior on appetitively motivated tasks were studied. Subjects received two exposures to an open field one week apart. Prior to the first exposure subjects were treated with small doses of Tween 80-water. At 30 min or 3 h prior to the second exposure subjects were treated with Tween or Δ 9-THC in doses which ranged from 0.5–5 mg/kg. Results indicated that Δ 9-THC affected various indices of open-field activity such as grooming, sniffing and ambulation differently depending on the time after injection. Rearing and defecation were affected similarly by THC independent of post-injection intervals.
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References
Abel, E. L.: Effects of the marihuana-homologue, pyrahexyl, on open-field behavior in the rat. J. Pharm. Pharmacol. 22, 785 (1970).
Bindra, D., Spinner, N.: Response to different degrees of novelty: the incidence of various activities. J. exp. Anal. Behav. 1, 341–350 (1958).
Garriott, J. L., King, L. J., Forney, R. B., Hughes, F. W.: Effect of some tetrahydrocannabinoids on hexobarbital sleeping-time and amphetamine induced hyperactivity in mice. Life Sci. 6, 2119–2128 (1967).
Grunfeld, T., Edery, H.: Psychopharmacological activity of the active constituents of hashish and some related cannabinoids. Psychopharmacologia (Berl.) 14, 200–210 (1969).
Hall, C. S.: Emotional behavior in the rat: I. Defecation and urination as measures of individual differences in emotionality. J. comp. Psychol. 18, 385–403 (1934).
Kršiak, M., Steinberg, H., Stolerman, I. D.: Uses and limitations of photocell activity cages for assessing effects of drugs. Psychopharmacologia (Berl.) 17, 258–274 (1970).
Masur, J., Marty, R. M. W., Carlini, E. A.: Effects of acute and chronic administration of cannabis sativa and (-)Δ 9-trans-tetrahydrocannabinol on the behavior of rats in an open field. Psychopharmacologia (Berl.) 19, 388–397 (1971).
Moreton, J. E., Davis, M. W.: Effects of Δ 9-tetrahydrocannabinol on locomotor activity and on phases of sleep. Pharmacologist 12, 258 (1970).
Nadel, L.: Dorsal and ventral hippocampal lesions and behavior. Physiol. Behav. 3, 891–900 (1968).
Newbury, E., Hull, L. D.: Electronic and time sampling measurement of general activity. Percept. and Motor Skills 30, 831–837 (1970).
Siegel, S.: Nonparametric statistics of the behavioral sciences. New York: McGraw-Hill 1956.
Streng, J.: Open-field behavior in four inbred mouse strains. Canad. J. Psychol. 25, 62–68 (1971).
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This research was supported by USPHS Grant No. R01-MH18392-01. The Δ 9-THC was supplied by Dr. John A. Scigliano, NIMH, Chevy Chase, Maryland. The authors wish to thank Dr. Patrick Deluca for assistance in the solvent studies.
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Drew, W.G., Miller, L.L. & Wikler, A. Effect of Δ9-THC on the open-field activity of the rat. Psychopharmacologia 23, 289–299 (1972). https://doi.org/10.1007/BF00404134
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DOI: https://doi.org/10.1007/BF00404134