Skip to main content
SpringerLink
Log in

Association of Visceral Fat Accumulation and Adiponectin Levels with Colorectal Neoplasia

  • Original Article
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

Purpose There are few studies addressing the association between measured values of visceral fat accumulation (VFA), adiponectin, and colorectal neoplasia. Our purpose is to investigate the association of VFA and serum adiponectin levels with colorectal adenoma and carcinoma patients. For this purpose, 54 patients with colorectal adenoma and carcinoma, diagnosed by colonoscopic evaluation, and 50 healthy control subjects were included. Patients were subjected to measurement of VFA and adiponectin level and calculation of insulin resistance. Results Patients with colorectal carcinoma had lower plasma adiponectin levels compared with controls. VFA level did not differ between patients and controls. Adiponectin level was found to be uncorrelated with VFA in the colorectal cancer and adenoma group. No correlation was found between insulin resistance and plasma adiponectin level and VFA. Conclusion Our findings suggest that decreased plasma adiponectin level may be a factor involved in the development of colon cancer or a secondary effect of the metabolic derangements in colorectal cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. MacInnis RJ, English DR, Hopper JL, Gertig DM, Haydon M, Giles GG. Body size and composition and colon cancer risk in women. Int J Cancer. 2006;118:1496–1500. doi:10.1002/ijc.21508.

    Article  PubMed  CAS  Google Scholar 

  2. Pischon T, Lahmann PH, Boeing H, et al. Body size and risk of colon and rectal cancer in the European prospective investigation into cancer and nutrition (EPIC). Natl Cancer Inst. 2006;98(13):920–931.

    Article  PubMed  Google Scholar 

  3. MacInnis RJ, English DR, Haydon AM, Hopper JL, Gertig DM, Giles GG. Body size and composition and risk of rectal cancer (Australia). Cancer Causes Control. 2006;17:1291–1297. doi:10.1007/s10552-006-0074-y.

    Article  PubMed  Google Scholar 

  4. Schoen RE, Tangen CM, Kuller LH, et al. Increased blood glucose and insulin, body size, and indent colorectal cancer. J Natl Cancer Inst. 1999;91:1147–1154. doi:10.1093/jnci/91.13.1147.

    Article  PubMed  CAS  Google Scholar 

  5. Fujioka S, Matsuzawa Y, Tokunaga K, Tarui S. Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism. 1987;36:54–59. doi:10.1016/0026-0495(87)90063-1.

    Article  PubMed  CAS  Google Scholar 

  6. Shuman WP, Morris LL, Leonetti DL, et al. Abnormal body fat distribution detected by computed tomography in diabetic men. Invest Radiol. 1986;21:483–487. doi:10.1097/00004424-198606000-00007.

    Article  PubMed  CAS  Google Scholar 

  7. Seidell JC, Oosterlee A, Thijssen MA, et al. Assessment of intra-abdominal and subcutaneous abdominal fat: relation between anthropometry and computed tomography. Am J Clin Nutr. 1987;45:7–13.

    PubMed  CAS  Google Scholar 

  8. Hotta K, Funahashi T, Arita Y, et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol. 2000;20:1595–1599.

    PubMed  CAS  Google Scholar 

  9. Kumada M, Kihara S, Sumitsuji S, et al. Osaka CAD Study Group. Coronary artery disease. Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol. 2003;23:85–89. doi:10.1161/01.ATV.0000048856.22331.50.

  10. Pajvani UB, Du X, Combs TP, et al. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivity. J Biol Chem. 2003;278:9073–9085. doi:10.1074/jbc.M207198200.

    Article  PubMed  CAS  Google Scholar 

  11. Pajvani UB, Hawkins M, Combs TP, et al. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem. 2004;279:12152–12162. doi:10.1074/jbc.M311113200.

    Article  PubMed  CAS  Google Scholar 

  12. Maeda N, Shimomura I, Kishida K, et al. Diet induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med. 2002;8:731–737. doi:10.1038/nm724.

    Article  PubMed  CAS  Google Scholar 

  13. Yamauchi T, Kamon J, Minokoshi Y, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med. 2002;8:1288–1295. doi:10.1038/nm788.

    Article  PubMed  CAS  Google Scholar 

  14. Zietz B, Herfarth H, Paul G, et al. Adiponectin represents an independent cardiovascular risk factor predicting serum HDL-cholesterol levels in type 2 diabetes. FEBS Lett. 2003;19:103–104. doi:10.1016/S0014-5793(03)00568-4.

    Article  CAS  Google Scholar 

  15. Thamer C, Haap M, Bachmann O, et al. Serum adiponectin levels predict the effect of short-term dietary inter ventions on insulin sensitivity in humans. Diabetologia. 2004;47:1303–1305. doi:10.1007/s00125-004-1430-7.

    Article  PubMed  CAS  Google Scholar 

  16. Dal Maso L, Augustın LSA, Karalıs A, et al. Circulating adiponectin and endometrial cancer risk. J Clin Endocrinol Metab. 2004;89(3):1160–1163. doi:10.1210/jc.2003-031716.

    Article  PubMed  CAS  Google Scholar 

  17. Miyoshi Y, Funahashi T, Kihara S, et al. Association of serum adiponectin levels with breast cancer risk. Clin Cancer Res. 2003;15:5699–5704.

    Google Scholar 

  18. Brakenhielm E, Veitonmaki N, Cao R, et al. Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc Natl Acad Sci USA. 2004;101:2476–2481. doi:10.1073/pnas.0308671100.

    Article  PubMed  CAS  Google Scholar 

  19. Yokota T, Oritani K, Takahashi I, et al. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood. 2000;96:1723–1732.

    PubMed  CAS  Google Scholar 

  20. Nieves DJ, Cnop M, Retzlaff B, et al. The atherogenic lipoprotein profile associated with obesity and insulin resistance is largely attributable to intra-abdominal fat. Diabetes. 2003;52:172–179. doi:10.2337/diabetes.52.1.172.

    Article  PubMed  CAS  Google Scholar 

  21. Fujita K, Nishizawa H, Funahashi T, Shimomura I, Shimabukuro M. Systemic oxidative stress is associated with visceral fat accumulation and the metabolic syndrome. Circ J. 2006;70:1437–1442. doi:10.1253/circj.70.1437.

    Article  PubMed  CAS  Google Scholar 

  22. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 1998;395:763–770. doi:10.1038/27376.

    Article  PubMed  CAS  Google Scholar 

  23. Matsuzawa Y, Funahashi T, Kihara S, Shimomura I. Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol. 2004;24:29–33. doi:10.1161/01.ATV.0000099786.99623.EF.

    Article  PubMed  CAS  Google Scholar 

  24. Ouchi N, Kihara S, Funahashi T, et al. Reciprocal association of C-reactive protein with adiponectin in blood streamand adipose tissue. Circulation. 2003;107:671. doi:10.1161/01.CIR.0000055188.83694.B3.

    Article  PubMed  CAS  Google Scholar 

  25. Engeli S, Feldpausch M, Gorzelniak K, et al. Association between adiponectin and mediators of inflammation in obese women. Diabetes. 2003;52:942–947. doi:10.2337/diabetes.52.4.942.

    Article  PubMed  CAS  Google Scholar 

  26. Otake S, Takeda H, Suzuki Y, et al. Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma: evidence for participation of insulin resistance. Clin Cancer Res. 2005;11:3642–3646. doi:10.1158/1078-0432.CCR-04-1868.

    Article  PubMed  CAS  Google Scholar 

  27. The Expert Committee. Report of the Expert Committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 1997;20:11833–11197.

    Google Scholar 

  28. Bonora E, Targher G, Alberiche M, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care. 2000;23:57–63. doi:10.2337/diacare.23.1.57.

    Article  PubMed  CAS  Google Scholar 

  29. Petridou E, Mantzoros C, Dessypris N, et al. Plasma adiponectin concentrations in relation to endometrial cancer: a case–control study in Greece. J Clin Endocrinol Metab. 2003;88(3):993–997. doi:10.1210/jc.2002-021209.

    Article  PubMed  CAS  Google Scholar 

  30. Wei EK, Giovannucci E, Fuchs CS, Willett WC, Mantzoros CS. Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study. J Natl Cancer Inst. 2005;97:1688–1694.

    PubMed  CAS  Google Scholar 

  31. Michalakis K, Catherine J, Williams L, et al. Serum adiponectin concentrations and tissue expression of adiponectin receptors are reduced in patients with prostate cancer: a case control study. Cancer Epidemiol Biomarkers Prev. 2007;16(2). doi:10.1158/1055-9965.EPI-06-0621.

  32. Larsson B, Svardsudd K, Welin L, Wilhelmsen L, Bjorntorp P, Tibblin G. Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913. Br Med J (Clin Res Ed). 1984;288:1401–1404.

    CAS  Google Scholar 

  33. Kissebah AH, Vydelingum N, Murray R, et al. Relation of body fat distribution to metabolic complications of obesity. J Clin Endocrinol Metab. 1982;54:254–260.

    Article  PubMed  CAS  Google Scholar 

  34. Folsom AR, Kaye SA, Sellers TA, et al. Body fat distribution and 5-year risk of death in older women [published erratum appears in JAMA. 1993;269:1254].

  35. Morimoto LM, White E, Chen Z, et al. Obesity, body size, and risk of postmenopausal breast cancer:the Women’s Health Initiative (United States). Cancer Causes Control. 2002;13:741–751. doi:10.1023/A:1020239211145.

    Article  PubMed  Google Scholar 

  36. Von Hafe P, Pina F, Pe’rez A, Tavares M, Barros H. Visceral fat accumulation as a risk factor for prostate cancer. Obes Res. 2004;12:1930–1935. doi:10.1038/oby.2004.242.

    Article  Google Scholar 

  37. Mantzoros C, Petridou E, Dessypris N, et al. Adiponectin and breast cancer risk. J Clin Endocrinol Metab. 2004;89:1102–1107. doi:10.1210/jc.2003-031804.

    Article  PubMed  CAS  Google Scholar 

  38. Lee HL, Son BK, Lee OY, et al. Abdominal obesity, insulin resistance, and the risk of colonic adenoma. Korean J Gastroenterol. 2007;49(3):147–151.

    PubMed  CAS  Google Scholar 

  39. Nishii T, Kono S, Abe H, et al. Glucose intolerance, plasma insulin levels, and colon adenomas in Japanese. Jpn J Cancer Res. 2001;92:836–840.

    PubMed  CAS  Google Scholar 

Download references

Acknowledgments

This work is supported by the Scientific Research Fund of Fatih University under project number P53010714.

Author information

Authors and Affiliations

  1. Department of Gastroenterology, Fatih University Medical School, Ankara, Turkey

    Elife Erarslan & Cansel Turkay

  2. Kızlarpınarı caddesi, 69 Sokak. No:13/15, Keçiören, Ankara, Turkey

    Elife Erarslan

  3. Department of Radiology, Fatih University Medical School, Ankara, Turkey

    Aslý Koktener

  4. Department of Clinic Biochemistry, Fatih University Medical School, Ankara, Turkey

    Cemile Koca

  5. Department of Internal Medicine, Fatih University Medical School, Ankara, Turkey

    Burak Uz & Nuket Bavbek

Authors
  1. Elife Erarslan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Cansel Turkay
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Aslý Koktener
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Cemile Koca
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Burak Uz
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Nuket Bavbek
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Elife Erarslan.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Erarslan, E., Turkay, C., Koktener, A. et al. Association of Visceral Fat Accumulation and Adiponectin Levels with Colorectal Neoplasia. Dig Dis Sci 54, 862–868 (2009). https://doi.org/10.1007/s10620-008-0440-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10620-008-0440-6

Keywords

Search

Navigation