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Whole-Body Insulin Sensitivity Index Is a Highly Specific Predictive Marker for Virological Response to Peginterferon Plus Ribavirin Therapy in Chronic Hepatitis C Patients with Genotype 1b and High Viral Load

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Abstract

Insulin resistance is a candidate predictive factor for virological response to peginterferon plus ribavirin (PEG/RBV) therapy in chronic hepatitis C patients. We examined whether indices of insulin resistance could serve as a predictor of sustained virological response (SVR). Fifty-one patients with genotype 1b and high viral load who received PEG/RBV therapy for 48 weeks were included. Homeostasis model assessment of insulin resistance (HOMA-IR) and whole-body insulin sensitivity index (WBISI) calculated from the 75-g oral glucose tolerance test and serum levels of soluble tumor necrosis factor receptor 2 (sTFNR2) were evaluated before therapy. Patients who achieved SVR had significantly lower HOMA-IR and sTNFR2 levels and a higher WBISI compared with non-SVR patients. The positive predictive value for SVR was 0.653 for a HOMA-IR of <2 and 0.846 for a WBISI of 6 or higher. WBISI may serve as a highly specific predictor for SVR in PEG/RBV therapy.

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Authors and Affiliations

  1. Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan

    Toshihiko Mizuta, Yasunori Kawaguchi, Yuichiro Eguchi, Hirokazu Takahashi, Keisuke Ario, Takumi Akiyama, Noriko Oza, Taiga Otsuka, Takuya Kuwashiro, Toru Yoshimura, Akitaka Hisatomi & Iwata Ozaki

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  1. Toshihiko Mizuta
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  2. Yasunori Kawaguchi
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  3. Yuichiro Eguchi
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Correspondence to Toshihiko Mizuta.

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Mizuta, T., Kawaguchi, Y., Eguchi, Y. et al. Whole-Body Insulin Sensitivity Index Is a Highly Specific Predictive Marker for Virological Response to Peginterferon Plus Ribavirin Therapy in Chronic Hepatitis C Patients with Genotype 1b and High Viral Load. Dig Dis Sci 55, 183–189 (2010). https://doi.org/10.1007/s10620-008-0691-2

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