Phenomenon of nitrate tolerance
References (98)
- et al.
Effects of long term oral administration of isosorbide dinitrate on the antiagninal response to nitroglycerin: absence of nitrate cross tolerance and self tolerance shown by exercise testing
Am J Cardiol
(1978) - et al.
Activation of guanylate cyclase from rat liver and other tissues by sodium azide
J Biol Chem
(1975) - et al.
The effects of nitroglycerin on cyclic nucleotides in the coronary artery in vivo
Life Sci
(1980) - et al.
Possible involvement of S-nitrosothiols in the activation of gunaylate cyclase by nitrous compounds
FEBS Lett
(1980) - et al.
Nitroglycerin and nitrate esters
Am J Med
(1978) - et al.
Effects of nitroglycerin at therapeutic doses on platelet aggregation in unstable angina and acute myocardial infarction
Am J Cardiol
(1990) - et al.
Induction and circumvention of nitrate tolerance applying different dosage intervals
Am J Med
(1987) - et al.
Transdermal isosorbide dinitrate in angina pectoris: effects of acute and sustained therapy
Am J Cardiol
(1984) - et al.
Usefulness of twice daily isosorbide 5′ mononitrate in preventing development of tolerance in angina pectoris
Am J Cardiol
(1987) - et al.
Transdermal nitroglycerin in angina pectoris: efficacy of intermittent application
J Am Coll Cardiol
(1987)
Transdermal nitroglycerin in angina pectoris
Am J Cardiol
Isosorbide dinitrate and glyceryl trinitrate: demonstration of cross tolerance in the capacitance vessels
Am J Cardiol
Hemodynamic resistance to intravenous nitroglycerin in severe congestive heart failure and restored response after diuresis
Am J Cardiol
Dissociation of cysteine and glutathione levels for nitroglycerin-induced relaxation
Eur J Pharmacol
Failure of captopril to prevent nitrate tolerance in congestive heart failure secondary to coronary artery disease
Am J Cardiol
intermittent transdermal nitroglycerin therapy in the treatment of chronic stable angina
J Am Coll Cardiol
Long term efficacy of continuous and intermittent use of transdermal nitroglycerin in stable angina pectoris
Am J Cardiol
Transdermal nitroglycerin reduces the frequency of angina attacks but fails to prevent silent ischemia
J Am Coll Cardiol
Induction and circumvention of nitrate tolerance applying different dosing intervals
Am J Med
Dissociation of exercise tolerance and total myocardial ischemic burden in chronic stable angina
Am J Cardiol
Oral anti-anginal nitrates should be indicated only for single, not chronic, use in absence of long-term data, FDA cardio-renal adyisory CMTE concludes
FDA Reports [The Pink Sheet]
Nitroglycerin as a remedy for angina pectoris
Lancet
The effects of nitroglycerin on those engaged in its manufacture
JAMA
The cause, relief and prevention of headaches rising from contact with dynamite
N Engl J Med
Remarkable tolerance to nitroglycerin
Philadelphia Polyclinic
The rate of elimination of glyceryl trinitrate from the blood stream after intravenous administration in dogs
J Pharmacol Exp Ther
Nitrate toleration
J Pharmacol Exp Ther
Acute coronary occlusion and myocardial infarction
Sustained effects of nitroglycerin ointment in patients with angina pectoris
Circulation
Tolerance towards glyceryl trinitrate (trinitrin) in dogs
Arch Int Pharmacodyn
Tolerance towards glyceryl trinitrate (trinitrin) in rabbits
Arch Int Pharmacodyn
Tolerance to the vascular effects of glyceryl trinitrate
J Pharmacol Exp Ther
Organic nitrates: tolerance at the level of the vascular smooth muscle
Arch Int Pharmacodyn
Metabolism of ethylene glycol dinitrate (ethylene dinitrate) in the rat following repeated administration
Br J Ind Med
Cyclic guanosine monophosphate as a mediator of vasodilation
J Clin Invest
Stimulation of gunaylate cyclase activity by sodium nitroprusside, nitroglycerin, and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine
J Cyclic Nucleotide Res
Calcium-independent modulation of cyclic GMP and activation of guanylate cyclase by nitrosamines
Science
Effects of stimulant and relaxant drugs on tension and cyclic nucleotide levels in canine femoral artery
Mol Pharmacol
Relationship between cyclic guanosine 3′,5′-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric acid: effects of methylene blue and methemoglobin
J Pharmacol Exp Ther
Characterization of protein inhibitors of guanasine cyclase activation from rat and bovine lung
J Biol Chem
Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates
J Pharmacol Exp Ther
Endothelium dependent relaxation in rat aorta may be mediated through cGMP dependent protein phosphorylation
Nature
Endothelium dependent and nitrovasodilator induced activation of cyclic GMP-dependent protein kinase in rat aorta
J Cyclic Nucleotide Prot Phosph Res
Endothelium dependent and nitrovasodilator-induced relaxation of vascular smooth muscle: role of cyclic GMP
J Cyclic Nucleotide Prot Phosph Res
Endothelium dependent vasodilator and nitrovasodilator induced relaxation may be mediated through cyclic GMP formation and cGMP dependent protein phosphorylation
Trans Assoc Am Phys
Late phase of nitroglycerin-induced coronary vasodilation blunted by inhibition of prostaglandin systems
Circulation
Cytosolic-free calcium transients in cultured vascular smooth muscle cells: microflurometric measurements
Science
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
Nature
Cited by (73)
Tailored therapy for aggressive dilatation of systemic veins and arteries may result in improved long-term Fontan circulation
2015, Journal of Thoracic and Cardiovascular SurgeryCitation Excerpt :Several important issues deserve further discussion to establish the efficacy and safety of the proposed tailored therapy. Adult patients on nitrates, including isosorbide dinitrate, may develop drug tolerance.8 Although we did not observe this effect in the children who underwent Fontan surgery in this study, after at least 1 year of administration, further studies with longer follow-up data are needed to address this issue.
Nitrate therapy for heart failure. Benefits and strategies to overcome tolerance
2013, JACC: Heart FailureCitation Excerpt :Continuous nitrate exposure leads to a depletion of sulfhydryl, limiting its vasodilatory capabilities (37). Interestingly, plasma nitrate concentrations are higher with short-term than with long-term therapy, even at the same dose (37,40). This combination of decreased functionality and increased inactivity leads to reversal of the physiologic benefits of nitrate and to the development of tolerance (21,26,37).
Exploiting cGMP-based therapies for the prevention of left ventricular hypertrophy: NO• and beyond
2009, Pharmacology and TherapeuticsPreserved endothelial function after long-term eccentric isosorbide mononitrate despite moderate nitrate tolerance
2003, Journal of the American College of CardiologyReduction of organic nitrates catalysed by xanthine oxidoreductase under anaerobic conditions
2001, Biochimica et Biophysica Acta - General Subjects