Elsevier

Brain Research

Volume 322, Issue 2, 26 November 1984, Pages 316-321
Brain Research

Bilateral midbrain transections block the behavioral effects of cholecystokinin on feeding and exploration in rats

https://doi.org/10.1016/0006-8993(84)90124-0Get rights and content

Abstract

The mechanism by which peripherally administered cholecystokinin (CCK) reduces feeding and exploration involves a sensory feedback pathway from the gastrointestinal regions, via the vagus nerve7,22,31 through the nucleus tractus solitarius (NTS)9. Bilateral dorsal midbrain transections rostral to the NTS abolish the ability of CCK to reduce food consumption, decrease exploratory approaches, and increase pauses of behavioral inactivity, as compared to these actions of CCK in normal and sham-lesioned control rats, suggesting that ascending NTS fibers are a necessary component in this feedback system.

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