Effects of antiinflammatory and immunosuppressive drugs on pregnancy and fertility
References (294)
Aspirin-induced cleft lip and other malformations in mice
Lancet
(1965)- et al.
Goldenhar's syndrome and phocomelia: Case report and etiologic considerations
Am J Ophthalmol
(1971) - et al.
Influence of acetylsalicylic acid, an inhibitor of prostaglandin synthesis, on the duration of human gestation and labour
Lancet
(1973) - et al.
Fetal effects of regular salicylate ingestion in pregnancy
Lancet
(1975) - et al.
Aspirin and congenital malformations
Lancet
(1976) - et al.
Morphologic analysis of the pulmonary vascular bed in infants exposed in utero to prostaglandin synthetase inhibitors
J Pediatr
(1978) - et al.
Prostaglandin synthesis in rat embryo tissue: The effect of non-steroidal antiinflammatory drugs in vivo and ex vivo
Prostaglandins
(1984) - et al.
Reproduction studies on sodium meclofenamate in comparison to aspirin and phenylbutazone
Toxicol Appl Pharmacol
(1969) - et al.
Effects of aspirin and acetaminophen on fetal and placental growth in rats
J Pharm Sci
(1977) - et al.
Indomethacin: Studies of absorption and placental transfer
Am J Obstet Gynecol
(1977)
Indomethacin—Placental transfer, cytotoxicity, and teratology in the rat
Am J Obstet Gynecol
Fetal and neonatal effects of indomethacin used as a tocolytic agent
Am J Obstet Gynecol
Neonatal outcome after indomethacin treatment for preterm labor
Am J Obstet Gynecol
The inhibition of premature labor with indomethacin
Am J Obstet Gynecol
Indomethacin and the fetal renal nonfunction syndrome
Eur J Obstet Gynecol Reprod Biol
Anti-fertility effect of non-steroidal anti-inflammatory drugs
Jpn J Pharmacol
Morphologic analysis of the pulmonary vascular bed in infants exposed in utero to prostaglandin synthetase inhibitors
J Pediatr
Effect on neonate of maternal treatment with indomethacin
J Pediatr
The effects of a number of non-steroidal anti-inflammatory compounds on parturition in the rat
Prostaglandins
Differential inhibition of fetal vascular prostacyclin and platelet thromboxane synthesis by nonsteroidal anti-inflammatory drugs in humans
Prostaglandins
Inhibition of ovulation by indomethacin in rats
Prostaglandins Leukotrienes Med
Perinatal use of indomethacin
Lancet
Naproxen levels in preterm infants after maternal treatment
Lancet
Effect on the fetus of indomethacin given to suppress labour
Lancet
Inhibitors of prostaglandin synthesis and fetal development
Lancet
Cortisone and pregnancy: An experimental and clinical study of the effects of cortisone on gestation
Am J Obstet Gynecol
Cortisone therapy in early pregnancy: relation to cleft palate
Lancet
Outcome for the foetus of mothers receiving prednisolone during pregnancy
Lancet
Pregnancy in inflammatory bowel disease: Effect of sulfasalazine and corticosteroids on fetal outcome
Gastroenterology
Urinary tetrabydrocortisone and tetrahydrocortisol in infants born of mothers treated with corticosteroids during pregnancy
J Pediatr
Treatment of hyperemesis gravidarum with cortisone: I. Fetal results
Am J Obstet Gynecol
Effect of adrenocorticoids during pregnancy
Lancet
The transplacental passage of prednisone and prednisolone in pregnancy near term
J Pediatr
Statistical Methods for Rates and Proportions
Measurement of observer agreement for categorical data
Biometrics
Foundations of Epidemiology
Congenital malformation surveillance, January, 1981–December 1983
Influence of maternal drug metabolism on the fetal toxicity induced by acetylsalicylic acid
J Toxicol Sci
Effect of acetylsalicylic acid on foetal rats
J Pharm Pharmacol
Toxic effects of salicylate on the foetus and mother
J Pathol Bacteriol
Development of aspirin hydrolase in fetal, newborn and adult tissues
Arch Surg
Aspirin: Teratogenic evaluation in the dog
Teratology
Salicylate-induced fetal death and malformations in two mouse strains
Acta Paediatr Scand
Experimental production of congenital malformations in rats by salicylate poisoning
Am J Pathol
The possible teratogenic effect of salicylates on the developing fetus: Summaries of eight suggestive cases
Clin Pediatr
Intrauterine salicylate intoxication in a newborn
Clin Pediatr
Associations between drugs administered during pregnancy and congenital abnormalities of the fetus
Br Med J
Salicylate-induced foetal damage late in pregnancy: An experimental study in mice
Acta Paediatr Scand
Maternal effects of regular salicylate ingestion in pregnancy
Lancet
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Management of hidradenitis suppurativa in pregnancy
2017, Journal of the American Academy of DermatologyCitation Excerpt :Metformin is excreted minimally into the breast milk and has not been shown to adversely affect breastfed infants.61 Overall, there is weak evidence supporting use of oral glucocorticoids,4 colchicine,3 cyclosporine,4 and methotrexate4 in HS (Tables IV and V).7,8,12,19,20,28,34,54-80 The risks associated with in utero exposure of these compounds outweigh potential benefits.
Clinical Teratology
2013, Emery and Rimoin's Principles and Practice of Medical GeneticsFemale patients suffering from inflammatory bowel diseases are treated less frequently with immunosuppressive medication and have a higher disease activity. A subgroup analysis of a large multi-centre, prospective, internet-based study
2011, Journal of Crohn's and ColitisCitation Excerpt :However, an age-related analysis (women age 18–42 vs. > 42 years) did not reveal any difference in the treatment of women in either CD or UC between both age groups. A therapy with AZA/6-MP, the most commonly used immunosuppressant in IBD, is generally considered to be of low risk during pregnancy.29–31 However, the relative contraindication for peri-conceptional use of thiopurines is still mentioned by the manufacturer in the patient information sheet.
Antimalarials and SLE
2011, Systemic Lupus ErythematosusThe second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Special situations
2010, Journal of Crohn's and ColitisCitation Excerpt :Most of the experience with AZA and MP in pregnancy comes from the transplant and rheumatology literature. AZA is considered safe in these populations, with no consistent reports of abnormalities of fertility, prematurity, or congenital defects.303–305 [ EL3b, RG B] The FDA rating (D) is, however, based on anecdotal reports of high abortion rates.306,307 [
Antimalarials and SLE
2010, Systemic Lupus Erythematosus, Fifth Edition
- 1
From the Division of Molecular and Clinical Rheumatology, Department of Medicine, the Johns Hopkins University School of Medicine and Hospital, Baltimore.