Gastroenterology

Gastroenterology

Volume 117, Issue 3, September 1999, Pages 740-741
Gastroenterology

Selected Summaries
Angiotensin II receptor antagonists in the pharmacological therapy of portal hypertension: A caution

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Abstract

GASTROENTEROLOGY 1999;117:740-741

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Comment

Various aspects of this study deserve comment, the first one being the remarkable effect on portal pressure attained with losartan. The mean reduction in HVPG of approximately 45% is the most pronounced pharmacological effect on portal hypertension described so far in cirrhotic patients. Before this study, the greatest reduction in HVPG had been 36%, which was reported in an early study of long-term oral administration of propranolol in cirrhotic patients (Hepatology 1982;2:523-527). Subsequent

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