Elsevier

Journal of Hepatology

Volume 27, Issue 4, October 1997, Pages 756-765
Journal of Hepatology

Treatment of hepatocellular carcinoma in patients with cirrhosis

https://doi.org/10.1016/S0168-8278(97)80095-5Get rights and content

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      The incidence of hepatocellular carcinoma (HCC), a tumor usually associated with liver cirrhosis or chronic infection with hepatitis B or C viruses, [1,2] is seeing sustained growth in Europe, Japan and USA [3,4]. Treatment for this cancer remains difficult; tumor resection or liver transplantation cannot be proposed to most patients because of their underlying liver disease or extension of the tumor at the time of diagnosis [5–8]. Gene therapy may constitute an attractive therapeutic alternative for HCC.

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      The severity of liver disease and the characteristics of the neoplasm are the main prognostic factors, and have been included in the traditional (5) and more recently proposed (6–9) prognostic classification systems. It has been suggested that both the natural history and the presentation of HCC at diagnosis may depend on the cause of the underlying chronic liver disease (10). Hepatitis B virus (HBV), hepatitis C virus (HCV), and alcohol intake have been definitely recognized as the main causes of HCC in developed countries (11, 12) and are responsible for most cases of cirrhosis (13, 14) and HCC (15–17) in Italy.

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