Abstract
The aim of this study was to determine the nationwide incidence of collagenous and lymphocytic colitis in Iceland and the location of histopathological changes in the large bowel. All pathology reports of patients diagnosed with or suspected of having collagenous colitis or lymphocytic colitis in the period 1995–1999 were identified. All pathology samples were reevaluated using strict diagnostic criteria. After reevaluation 125 patients fulfilled our diagnostic criteria, 71 as collagenous colitis and 54 as lymphocytic colitis. The mean annual incidence for collagenous colitis was 5.2/100,000 inhabitants, and the mean age at diagnosis was 66.1 years. The mean annual incidence for lymphocytic colitis was 4.0/100,000 inhabitants, the mean age at diagnosis was 68.7 years. Both diseases more commonly involved the colon than the rectum. The incidence of collagenous colitis and lymphocytic colitis is high in Iceland. The mean annual incidence of collagenous colitis is much higher in Iceland than hitherto reported elsewhere.
Similar content being viewed by others
REFERENCES
Lindström CG: “Collagenous colitis” with watery diarrhoea--a new entity? Pathol Eurp 11:87–89, 1976
Read NW, Krejs GJ, Read MG, Santa Ana CA, Morawski SG, Fordtran JS: Chronic diarrhea of unknown origin. Gastroenterology 78:264–271, 1980
Lazenby A, Yardley J, Giardiello FM, Jessurun J, Bayless T: Lymphocytic (microscopic) colitis. A comparative histopathologic study, with particular reference to collagenous colitis. Hum Pathol 20:18–28, 1989
Levison DA, Lazenby AJ, Yardley JH: Microscopic colitis cases revisited. Gastroenterology 105:1594–1596, 1993
Bohr J, Tysk C, Eriksson S, Jårnerot G: Collagenous colitis in Örebro, Sweden, an epidemiological study. Gut 37:394–397, 1995
Fernández-Bañares F, Salas A, Forné M, Esteve M, Espinós J, Viver JM: Incidence of collagenous and lymphocytic colitis: A 5-year population-based study. Am J Gastroenterol 94:418–423, 1999
Baert F, Wouters K, D'Haens G, Hoang P, Naegels S, D'Heygere F, Holvoet J, Louis E, Devos M, Geboes K: Lymphocytic colitis: A distinct clinical entity? A clinicopathological confrontation of lymphocytic and collagenous colitis. Gut 45:375–381, 1999
Bogomoletz WV: Collagenous, microscopic and lymphocytic colitis. An evolving concept. Virchows Arch 424:573–579, 1994
Shurberg JL, McCoy KL, Yardley JH, Travers RD, Giardiello FM, Lazenby AJ: Collagenous colitis seen in 1320 patients with chronic diarrhea in a community practice of gastroenterology from 1976–1986. Gastroenterology 94:A426, 1988
Lazenby AJ, Yardley JH, Giardiello FM, Bayless TM: Pitfalls in the diagnosis of collagenous colitis: Experience with 75 cases from a registry of collagenous colitis at the Johns Hopkins Hospital. Hum Pathol 21:905–910, 1990
Bogomoletz WV, Fléjou JF: Newly recognized forms of colitis: Collagenous colitis, microscopic (lymphocytic) colitis, and lymphoid follicular proctitis. Semin Diagn Pathol 8:178–189, 1991
Zins BJ, Sandborn WJ, Tremaine WJ: Collagenous and lym-phocytic colitis: Subject review and therapeutic alternatives. Am J Gastroenterol 90:1394–1400, 1995
Smith DA, Germolec DR: Introduction to immunology and autoimmunity. Environ Health Perspect 107(suppl 5):661–665, 1999
Bohr J, Tysk C, Yang P, Danielsson D, Järnerot G: Autoantibodies and immunoglobulins in collagenous colitis. Gut 39:73–76, 1996
Giardiello FM, Lazenby AJ, Yardley JH, Bias WB, Johnson J, Alianiello RG, Bedine MS, Bayless TM: Increased HLA A1 and diminished HLA A3 in lymphocytic colitis compared to controls and patients with collagenous colitis. Dig Dis Sci 37:496–499, 1992
Tanaka M, Mazzoleni G, Riddell RH: Distribution of collagenous colitis: Utility of flexible sigmoidoscopy. Gut 33:65–70, 1992
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Agnarsdottir, M., Gunnlaugsson, O., Orvar, K.B. et al. Collagenous and Lymphocytic Colitis in Iceland. Dig Dis Sci 47, 1122–1128 (2002). https://doi.org/10.1023/A:1015058611858
Issue Date:
DOI: https://doi.org/10.1023/A:1015058611858