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Prospective Evaluation of Intestinal Metaplasia and Dysplasia Within the Cardia of Patients with Barrett's Esophagus

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Abstract

The prevalence of cardia versus noncardiagastric intestinal metaplasia in patients with Barrett'sesophagus was assessed prospectively. Four-quadrantbiopsies were obtained from the cardia from 119consecutive patients with Barrett's esophagus and 64control patients. Gastric surveillance biopsies wereobtained in 108 of the Barrett's patients and 58 controlpatients. There was a significantly greater prevalence of cardia intestinal metaplasia inshort-segment Barrett's (10.2%), but not traditionalBarrett's (3.3%), compared to control patients (0%) (P= 0.009). Dysplastic changes were significantly morefrequent in the metaplastic epithelium within theesophagus than in the cardia (P < 0.0001). Asignificantly greater prevalence of noncardia intestinalmetaplasia compared to cardia intestinal metaplasia wasfound in each of the three groups of patients;however, the prevalence of noncardia intestinalmetaplasia between short-segment, traditional, andcontrol patients was not significantly different. Cardiaintestinal metaplasia was an infrequent finding inpatients with Barrett's esophagus and appears to developindependently from that in the remainder of thestomach.

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Weston, A.P., Krmpotich, P.T., Cherian, R. et al. Prospective Evaluation of Intestinal Metaplasia and Dysplasia Within the Cardia of Patients with Barrett's Esophagus. Dig Dis Sci 42, 597–602 (1997). https://doi.org/10.1023/A:1018811512939

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