Abstract
Intestinal inflammation may influenceintraluminal pH. Profiles of the gastrointestinal pHwere evaluated in 15 patients with active Crohn'sdisease of the ileocecal area. In addition, fivepatients with moderate (1) or severe (4) ulcerative colitiswere studied. Fifteen healthy subjects served ascontrols. Intraluminal pH of the different parts of thegastrointestinal tract was measured by a free-floating pH-sensitive telemetering capsule. A metalsphere was attached to the capsule for exactlocalization by a metal detector. Physiological patternsof pH were maintained throughout the gastrointestinaltract including the inflamed segments. Median pH inthe terminal ileum of the patients with Crohn's diseasewas 7.5 vs 7.7 and in the rectum in ulcerative colitis7.8 vs 7.2 in the controls. In conclusion, intraluminal pH is not decreased by inflammatory changes inCrohn's disease and ulcerative colitis, allowingeudragit-coated pH-controlled-release formulations ofmesalazine to dissolve in diseased areas also.
Similar content being viewed by others
REFERENCES
Fallingborg J, Christensen LA, Jacobsen BA, Rasmussen SN: Very low intraluminal colonic pH in patients with active ulcerative colitis. Dig Dis Sci 38:1989–1993, 1993
Sasaki Y, Hada R, Nakajima H, Fukuda S, Munakata A: Improve d localizing me thod of radiopill in measurement of entire gastrointestinal pH profiles: Colonic luminal pH in normal subjects and patients with Crohn's disease. Am J Gastroenterol 92:114–118, 1997
Best WR, Becktel JM, Singleton JW, Kern F: Development of a Crohn's disease activity index. National cooperative Crohn's disease study. Gastroenterology 70:439–444, 1976
Raimondo AH, Evans DF, Rogers J, Silk DBA: Gastrointestinal pH-profiles in ulce rative colitis. Gastroenterology 102:A681, 1992
Truelove S, Witts L: Cortisone in ulcerative colitis. File report on therapeutic trial. Br Med J 2:1041–1048, 1955
Evans DF, Pye G, Bramley R, Clark AG, Dyson TJ, Hardcastle JD: Measurements of gastrointestinal pH-profiles in normal ambulant human subjects. Gut 29:1035–1041, 1988
Ewe K, Press AG, Dederer W: Gastrointestinal transit of indigestible solids measured by metal detector EAS II. Eur J Clin Invest19:291–297, 1989
Fallingborg J, Christensen LA, Ingeman-Nielsen M, Jacobsen BA, Abildgaard K, Rasmussen HH: pH-profile and regional transit times of the normal gut measured by a radiotelemetry device. Aliment Pharmacol Ther 3:605–613, 1989
Pye G, Evans DF, Ledingham S, Hardcastle JD: Gastrointestinal intraluminal pH in normal subjects and those with colorectal adenoma or carcinoma. Gut 31:1355–1357, 1990
Zimmermann T, Leitold M: The influence of food intake on gastrointestinal pH and gastric emptying time. Experience with two radiotelemetering methods (Heidelberg pH capsule system and Flexilog 1010). Int J Clin Pharmacol Ther Toxicol 30:477–478, 1992
Lauritsen K, Laursen LS, Burkhave K, Rask-Madsen J: Effects of topical 5-aminosalicylic acid and prednisolone on prostaglandine E2 and leukotriene B4 levels determined by equilibrium in vivo dialysis of rectum in relapsing ulcerative colitis. Gastroenterology 91:837–844, 1986
Stenson WF: Leukotrien B4 in inflammatory bowel disease. Can J Gastroenterol 7:182–186, 1993
Vernia P, Caprilli R, Latella G, Barbetti F, Magliocca FM, Cittadini M: Fecal lactate and ulcerative colitis. Gastroenterology 95:1564–1568, 1988
Roediger W EW: The colonic epithelium in ulcerative colitis: An energy deficiency syndrome? Lancet 2:712–715, 1980
van der Wiel-Konstantje JAA, Winkler KC: The fecal flora in ulcerative colitis. J Med Microbiol 8:491–501, 1975
Breuer R, Schilli R, Dum K, Gnaediger A, Pernicky S: Fecal fluid composition in Crohn's disease of the colon (CDS) differs from that in ulcerative colitis (CUC). Gastroe nterology 83:1025–1028, 1982
Caprilli R, Frieri G, Latella G, Vernia P, Santoro ML: Fecal excre tion of bicarbonate in ulcerative colitis. Digestion 35:136–142, 1986
Meldrum JS, Watson BW, Riddle HC, Bown LR, Sladen GE: pH profile of gut measured by radioteleme try capsule. Br Med J 2:104–106, 1972
Vernia P, Gnaedinger A, Hauck W, Breuer RI: Organic anions and the diarrhoea of inflammatory bowel disease. Dig Dis Sci 93:1353–1358, 1988
Lucas ML, Cooper BT, Lei FH: Acid microclimate in coeliac and Crohn's disease: A model for folate malabsorption. Gut 19:735–742, 1978
Press AG, Hauptmann IA, Hauptmann L, Fuchs B, Fuchs M, Ewe K, Ramadori G: Gastrointestinal pH profiles in patients with inflammatory bowel disease. Aliment Pharmacol Ther 12:673–678, 1998
Rights and permissions
About this article
Cite this article
Ewe, K., Schwartz, S., Petersen, S. et al. Inflammation Does Not Decrease Intraluminal pH in Chronic Inflammatory Bowel Disease. Dig Dis Sci 44, 1434–1439 (1999). https://doi.org/10.1023/A:1026664105112
Issue Date:
DOI: https://doi.org/10.1023/A:1026664105112