Autoimmune processes that destroy insulin-producing cells in the pancreas cause type 1 diabetes. To prevent the disease, autoreactive immune cells need to be suppressed or eliminated without deleterious side effects. Results from a phase 2 clinical trial take steps in this direction.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Katie Ris
References
The Canadian-European Randomized Control Trial Group. Diabetes 37, 1574–1582 (1988).
Rother, K.I. & Harlan, D.M. J. Clin. Invest. 114, 877–883 (2004).
Herold, K.C. et al. N. Engl. J. Med. 346, 1692–1698 (2002).
Chatenoud, L. et al. N. Engl. J. Med. 352, 2598–2608 (2005).
Sutherland, D.E. et al. Trans. Assoc. Am. Physicians 97, 80–87 (1984).
Chatenoud, L., Thervet, E., Primo, J. & Bach, J.F. Proc. Natl. Acad. Sci. USA 91, 123–127 (1994).
Herold, K.C. et al. Diabetes 54, 1763–1769 (2005).
The Diabetes Control and Complications Trial Research Group. Ann. Intern. Med. 128, 517–523 (1998).
Swinnen, L.J. et al. N. Engl. J. Med. 323, 1723–1728 (1990).
Smith, J.A., Tso, J.Y., Clark, M.R., Cole, M.S. & Bluestone, J.A. J. Exp. Med. 185, 1413–1422 (1997).
Smith, J.A., Tang, Q. & Bluestone, J.A. J. Immunol. 160, 4841–4849 (1998).
Walker, M.R. et al. J. Clin. Invest. 112, 1437–1443 (2003).
Homann, D. et al. Immunity 11, 463–472 (1999).
Skyler, J.S. et al. Diabetes Care 28, 1068–1076 (2005).
Nakayama, M. et al. Nature 435, 220–223 (2005).
von Herrath, M.G. & Harrison, L.C. Nat. Rev. Immunol. 3, 223–232 (2003).
Harlan, D.M. Endocrinology 145, 463–466 (2004).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Harlan, D., von Herrath, M. Immune intervention with anti-CD3 in diabetes. Nat Med 11, 716–718 (2005). https://doi.org/10.1038/nm0705-716
Issue Date:
DOI: https://doi.org/10.1038/nm0705-716
This article is cited by
-
The accelerator hypothesis: a review of the evidence for insulin resistance as the basis for type I as well as type II diabetes
International Journal of Obesity (2009)
