Regular Article
Interaction of non-alcoholic fatty liver disease with other liver diseases

https://doi.org/10.1053/bega.2002.0329Get rights and content

Abstract

Obesity-related steatosis is an increasingly common histological finding in liver biopsies and may co-exist with other chronic liver diseases. Although non-alcoholic fatty liver disease (NAFLD) without true steatohepatitis is generally a benign condition, when another liver disease is present, steatosis may exacerbate the liver damage. In this review, we discuss the interaction of obesity-related steatosis with chronic hepatitis C, alcoholic liver disease, disorders of hepatic iron storage and drug-induced liver disease. The role of weight reduction in minimizing liver injury in patients with chronic hepatitis C is discussed. Finally, we discuss the problems associated with orthotopic liver transplantation for patients with NAFLD.

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    All correspondence to: Dr Elizabeth E. Powell, Princess Alexandra Hospital, Ipswich Rd, Woolloongabba, Brisbane, Queensland 4102, Australia. Tel: +61 7 3240 2035; Fax: +61 7 3240 2337; E-mail: [email protected]

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