Gastrin secretion from primary cultures of rabbit antral G cells: Stimulation by inflammatory cytokines
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Gastrin attenuates sepsis-induced myocardial dysfunction by down-regulation of TLR4 expression in macrophages
2023, Acta Pharmaceutica Sinica BGenetic host factors in Helicobacter pylori-induced carcinogenesis: Emerging new paradigms
2018, Biochimica et Biophysica Acta - Reviews on CancerCitation Excerpt :Both infection with H. pylori or injection with IL1β causes inhibition of Shh signaling which precedes the disappearance of parietal cells and development of gastric atrophy [95]. Furthermore, IL1β stimulates gastrin production of G-cells [96], which may contribute to oncogenic signaling (as described above). Thirdly, gastric-restricted overexpression of IL1β in mouse models rapidly results in gastric inflammation, dysplasia and cancer by mobilizing myeloid-derived suppressor cells through IL1R-NFκB signaling [97].
Epinecidin-1 antimicrobial activity: In vitro membrane lysis and In vivo efficacy against Helicobacter pylori infection in a mouse model
2015, BiomaterialsCitation Excerpt :IL-17 induces the secretion of IL-8, which attracts neutrophils, thereby promoting inflammation [54]. TNF-a, together with Il-1β, induces gastrin, suggesting a role for these cytokines in H. pylori-induced hypergastrinemia and inflammatory responses [55–58]. IL-6 promotes Th17 cell growth and differentiation during H. pylori infection [59].
Alterations of rat stomach endocrine cells under renovascular hypertension
2014, Advances in Medical SciencesCitation Excerpt :A similar increase in the number of gastrin-containing cells was observed in a study concerning rats with spontaneous hypertension [1]. Given the enhanced secretion of proinflammatory mediators in hypertension state and the stimulatory effect of various inflammatory cytokines on gastrin secretion, the above findings can be explained by involvement of inflammatory processes in the regulation of the activity of G-cells [23–26]. Clinical observations confirm that patients with inflammatory bowel disease have significantly elevated gastrin serum level [25].
Immunology of Helicobacter pylori: Insights Into the Failure of the Immune Response and Perspectives on Vaccine Studies
2007, GastroenterologyCitation Excerpt :In developing countries, hypochlorhydria associated with the initial H pylori infection in infants may play a key role in the acquisition of other diarrheal pathogens.138,139 Whereas pro-inflammatory cytokines have a negative effect on parietal cells, in contrast, gastrin secretion from cultured G cells is stimulated by a range of cytokines, including interferon-γ,140,141 IL-1β, TNF-α, and IL-8.142,143 As H pylori strains with the cag PAI promote enhanced mucosal chemokine and cytokine responses in infected patients,59,134,144 an important question is whether there are strain variations in gastrin responses.
Abomasal contents of parasitised sheep contain an inhibitor of gastrin secretion in vitro
2006, Research in Veterinary Science