Alimentary TractPrimary gastric B-Cell lymphoma: Results of a prospective multicenter study☆,☆☆,★
Section snippets
Design
Patients were enrolled at 163 clinical centers in Germany and 13 in Austria. They were accepted for inclusion in the study only if a central histologic review (carried out by A.G. and H.-K. M.-H.) confirmed the diagnosis of primary gastric B-cell lymphoma. The study was approved by the ethics committees of the universities of Würzburg and Vienna. All patients gave written informed consent.
Patients
From March 1993 through March 1996, 266 adult patients with newly diagnosed primary gastric B-cell lymphoma
Clinical features
A total of 266 patients had a diagnosis of primary gastric B-cell lymphoma. Their clinical characteristics are summarized in Table 1.The vast majority of both low-grade and high-grade lymphoma proved to be localized (n = 237; Figure 1), presenting in stage EI/EII in 91% and 88%, respectively (P > 0.05). However, confinement to mucosa and submucosa (stage EI1) was more common in low-grade lymphoma (62%) than in those of high malignancy (13%; P < 0.001). Twenty-eight patients were found to have
Discussion
It has become clear in recent years that primary gastric B-cell lymphoma has a special place among malignant non-Hodgkin's lymphomas, constituting approximately 70% of primary extranodal lymphomas of gastrointestinal origin, because of the tumor's histomorphologic and molecular-genetic characteristics, cell-biologic properties, and clinical behavior, as reflected in the newly formulated REAL classification of malignant lymphoma.12 To our knowledge, this series of primary gastric lymphoma is the
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Address requests for reprints to: Wolfgang Fischbach, M.D., Medizinische Klinik II, Klinikum Aschaffenburg, Am Hasenkopf, D-63739 Aschaffenburg, Germany. Fax: (49) 6021-323031.
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Supported by a grant from the German Cancer Research Fund (Deutsche Krebshilfe, Bonn).
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Dedicated to the memory of Thadda ̈us Radaszkiewicz.