Clinical ResearchHelicobacter pylori eradication does not exacerbate reflux symptoms in gastroesophageal reflux disease☆,☆☆,★,★★
Section snippets
Materials and methods
This was a double blind, single dummy, parallel group randomized trial performed by 2 centers (Leeds and Rotherham) in the United Kingdom between July 1995 and August 1998. Patients over the age of 17 years were considered for recruitment if they had recurrent heartburn for at least 1 year as a dominant complaint and at least moderate symptoms for a minimum of 2 days each week for the previous 2 weeks. Subjects with grade A esophagitis or a normal endoscopy were enrolled. Exclusion criteria
Results
Two hundred fifty-one patients were recruited to the study; 190 were H. pylori positive and 61 were H. pylori negative. The H. pylori–positive cases were randomized to antibiotics (n = 93) or placebo antibiotics (n = 97). The baseline characteristics were similar between the 2 groups (Table 1).Variable Placebo group (n = 93) Antibiotic group (n = 85) H. pylori–negative group (n = 54) No. of males (%)
Discussion
This is the first randomized controlled trial to evaluate the effect of H. pylori eradication on reflux symptoms and esophagitis in GERD patients. There was an 83% relapse rate in GERD symptoms at 12 months in the antibiotic and placebo groups. This relapse rate is consistent with the previous literature14 and was also seen in the H. pylori–negative controls. These data suggest that H. pylori infection does not have a clinically important impact on relapse rates in Los Angeles grade A
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Cited by (212)
Houston Consensus Conference on Testing for Helicobacter pylori Infection in the United States
2018, Clinical Gastroenterology and HepatologyCitation Excerpt :If endoscopy is done for any reason such as to evaluate heartburn symptoms, it would be prudent to include gastric biopsy to exclude H pylori infection. Treatment of H pylori in patients with GERD does not alter the course or treatment of that disease.1,31 Gastric B cell lymphoma (also known as MALT lymphoma) and gastric cancer are both etiologically related to H pylori infection.32
The effect of helicobacter pylori eradication therapy on the development of gastroesophageal reflux disease
2015, American Journal of the Medical SciencesEffects of Helicobacter pylori eradication on esophageal motility, esophageal acid exposure, and gastroesophageal reflux disease symptoms
2023, Frontiers in Cellular and Infection MicrobiologyDisease trends after Helicobacter pylori eradication based on Japanese nationwide claims and the health check-up database
2023, World Journal of Gastroenterology
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Address requests for reprints to: Paul Moayyedi, Ph.D., FRCP, Gastroenterology Unit, City Hospital NHS Trust, Dudley Road, Winson Green, Birmingham, B18 7QH England. e-mail: [email protected]; fax: (44) 121-414-6571.
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Supported by a research grant from AstraZeneca.
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Dr. Moayyedi is currently funded by a UK Medical Research Council Training Fellowship in Health Services Research.
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Dr. Brown is an employee of AstraZeneca.