Clinical-alimentary tractMeta-analysis of the relationship between cagA seropositivity and gastric cancer
Section snippets
Justification for the meta-analysis
A computerized literature search was performed in the Medline and PubMed databases for relevant systematic reviews, published in all languages from 1990 to July 2003, using the following MeSH terms: meta-analysis, stomach neoplasms, Helicobacter pylori. The following text words also were searched: meta-analysis, systematic review, overview, gastric or stomach cancer or carcinoma or adenocarcinoma, pylori and cagA. A total of 29 potentially relevant citations were identified. Using the
Results
The literature search generated 228 potentially relevant citations. Screening of citation titles and abstracts identified 24 studies for full article review.6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34 Eight of these studies subsequently were excluded: no serologic testing for H. pylori infection,24, 25, 30 no age-matched controls,26, 31 no raw data,32 and duplicate publications.33, 34
Further search of meeting abstracts identified 4 studies that met
Discussion
We have shown previously through a meta-analysis of epidemiologic studies that H. pylori infection increases the risk for gastric cancer 1.9-fold overall.3 The results have been confirmed by others using a similar analytical approach.4, 41, 42 More recent studies also have suggested that patients infected with cagA-positive strains of H. pylori are at significantly higher risk for developing gastric cancer than those carrying cagA-negative strains.9, 10, 12, 16, 17, 23 However, it is unclear
References (45)
- et al.
Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer
Gastroenterology
(1998) - et al.
Association between infections with CagA-positive or -negative strains of Helicobacter pylori and risk for gastric cancer in young adults. Research Group on Prevention of Gastric Carcinoma among Young Adults
Am J Gastroenterol
(1999) - et al.
Helicobacter pylori in gastric cancer estimated by cagA immunoblot as a marker of past infection
Gastroenterology
(2001) - et al.
Guidelines for reading case-control studies
J Chron Dis
(1987) - et al.
The interrelationship between Helicobacter pylori vacuolating cytotoxin and gastric carcinoma
Am J Gastroenterol
(1998) - et al.
Association of Helicobacter pylori infection with gastric carcinomaa meta-analysis
Am J Gastroenterol
(1999) Human gastric carcinogenesisa multistep and multifactorial process—first American cancer society award lecture on cancer epidemiology and prevention
Cancer Res
(1992)Schistosomes, liver flukes and Helicobacter pylori IARC monographs on the evaluation of carcinogenic risks to humans. Volume 61
(1994)Gastric cancer and Helicobacter pyloria combined analysis of 12 case control studies nested within prospective cohorts
Gut
(2001)- et al.
Helicobacter pylori infection and the development of gastric cancer
N Engl J Med
(2001)
Helicobacter pylori strain types and risk of gastric cancera case-control study
Cancer Epidemiol Biomarkers Prev
Serum antibodies against Helicobacter pylori proteins VacA and CagA are associated with increased risk for gastric adenocarcinoma
Dig Dis Sci
Antibody against Helicobacter pylori CagA and VacA and the risk for gastric cancer
J Clin Pathol
Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection
Gut
Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach
Cancer Res
Individual and joint contribution of family history and Helicobacter pylori infection to the risk of gastric carcinoma
Cancer
An inverse relation between cagA+ strains of Helicobacter pylori infection and risk of esophageal and gastric cardia adenocarcinoma
Cancer Res
Helicobacter pylori seropositivity and subsite-specific gastric cancer risks in Linxian, China
J Natl Cancer Inst
cagA-positive Helicobacter pylori and risk for developing gastric carcinoma in Brazil
Int J Cancer
CagA seropositivity associated with development of gastric cancer in a Japanese population
Clin Pathol
Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group
JAMA
Heterogeneity in meta-analysis of data from epidemiologic studiesa commentary
Am J Epidemiol
Cited by (476)
New Rapid Helicobacter Pylori Blood Test Based on Dual Detection of FliD and CagA Antibodies for On-Site Testing
2023, Clinical Gastroenterology and HepatologyPartners in crime: The Lewis Y antigen and fucosyltransferase IV in Helicobacter pylori-induced gastric cancer
2022, Pharmacology and TherapeuticsCitation Excerpt :According to Western et al., the East-Asian cagA positive strain appears to be more closely associated with gastric cancer mortality worldwide (Huang, Zheng, Sumanac, Irvine, & Hunt, 2003). The gastric cancer prevalence in East Asian countries may be affected by the endemic circulation of H. pylori populations having more virulent East-Asian CagA proteins(Huang et al., 2003). CagA disturbs the signaling pathways and cell-cell interactions that contribute to tumor development(Björkholm et al., 2002).
Helicobacter pylori CagA-mediated ether lipid biosynthesis promotes ferroptosis susceptibility in gastric cancer
2024, Experimental and Molecular MedicineHistorical and Molecular Perspectives on the Presence of Helicobacter pylori in Latin America: A Niche to Improve Gastric Cancer Risk Assessment
2024, International Journal of Molecular Sciences
- 1
J. Q. H. is currently at the Clinical Trials Centre and Department of Gastroenterology, Queen Mary Hospital, University of Hong Kong, China (e-mail: [email protected]).