Gastroenterology

Gastroenterology

Volume 135, Issue 4, October 2008, Pages 1420-1422
Gastroenterology

Selected Summary
Step-Up and Top-Down Approaches to the Treatment of Crohn's Disease: Early May Already Be Too Late

https://doi.org/10.1053/j.gastro.2008.08.017Get rights and content

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This study is particularly relevant because it is the first study to investigate differences between treatment regimens for intervention in CD. However, several aspects of the trial should be taken into account. Even though the primary objective of the study was reached (remission without corticosteroids and without bowel resection at weeks 26 and 52), the study design is such that long-term, definitive conclusions cannot be drawn.

First, this was an unblinded randomized trial. Unblinding was

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    2010, Clinical Gastroenterology and Hepatology
  • Low-Dose Maintenance Therapy With Infliximab Prevents Postsurgical Recurrence of Crohn's Disease

    2010, Clinical Gastroenterology and Hepatology
    Citation Excerpt :

    One could speculate that in the postsurgical setting Crohn's disease may be much more responsive to medical therapy because of the relatively short natural history and the absence of complications. In addition, early phases of disease may be driven by cytokines (eg, TNF-α) different from those of late phases (reviewed by Peyrin-Biroulet et al27). Our study does not clarify whether treatment with more than 3 infusions at the lower doses of infliximab (1 and 2 mg/kg bw) would have shown efficacy in restoring mucosal integrity.

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