Chest
ORIGINAL RESEARCHLUNG CANCERSignificance of Multiple Carcinoid Tumors and Tumorlets in Surgical Lung Specimens: Analysis of 28 Patients
Section snippets
Study Group
The Mayo Clinic pathology database was searched for patients with a diagnosis of carcinoid tumor or tumorlet who underwent either surgical lung biopsy or lung resection between January 1, 1987 and December 31, 2000. Only patients with two or more carcinoid tumors and/or tumorlets were included in the final study group. The study was approved by the Mayo Foundation Institutional Review Board.
Clinical Data
Medical records were reviewed and the following data were recorded: age at surgery, gender, smoking
Results
Twenty-eight of 294 patients (9.5%) seen at the Mayo Clinic between 1987 and 2000 with a diagnosis of carcinoid tumor or tumorlet had two or more lesions. Twenty-six patients (93%) were women. Mean age at diagnosis was 65 years (range, 45 to 84 years). Thirteen patients (44%) were past or current smokers, with average exposures of 24 pack-years (range, 2 to 90 pack-years) [Table 1]. Patients were classified into three groups based on preoperative clinical and radiologic findings (Table 2).
Discussion
Multiple nodules mimicking pulmonary metastases is the most common setting in which multiple carcinoid tumors and tumorlets are discovered in surgical lung specimens. Darvishian and colleagues16 recently described 12 women who presented with multiple lung nodules 1 month to > 13 years after diagnosis of various types of malignant breast neoplasms. Their experience augments a previous report17 of a 63-year-old woman discovered to have multiple tumorlets after surgery for presumed metastatic
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2022, Practical Pulmonary Pathology: A Diagnostic ApproachLung carcinoid tumors with Diffuse Idiopathic Pulmonary NeuroEndocrine Cell Hyperplasia (DIPNECH) exhibit pejorative pathological features
2021, Lung CancerCitation Excerpt :Despite the absence of significant influence of DIPNECH on overall survival (OS), probably due to the relative low number of patients and event occurrence (death), we surprisingly found statistically higher amount of atypical carcinoid histology. This striking result is rather unexpected, as it was usually assumed, in previous series of comparable size, that carcinoid tumors associated with DIPNECH syndrome were preferentially typical and peripheral [22,2,7]. To our knowledge, it is the first study to report a higher AC/TC ratio in a well characterized series of DIPNECH patients.
This work performed at the Mayo Clinic, Rochester, MN.
The authors have no personal or financial conflicts of interest relative to the content of this article.