Antigen processing and presentation by intestinal epithelial cells - polarity and complexity

R M Hershberg; L F Mayer

doi:10.1016/s0167-5699(99)01575-3

Antigen processing and presentation by intestinal epithelial cells - polarity and complexity

Immunol Today. 2000 Mar;21(3):123-8. doi: 10.1016/s0167-5699(99)01575-3.

Authors

R M Hershberg¹, L F Mayer

Affiliation

¹ Divisions of Gastroenterology and Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

PMID: 10689299
DOI: 10.1016/s0167-5699(99)01575-3

Abstract

The mechanisms by which gut-associated lymphoid tissue (GALT) maintains a balance between oral tolerance and active immune response in the face of exposure to high antigen concentrations remains a central question in mucosal immunity. Here, Robert Hershberg and colleagues discuss the evidence that human intestinal epithelial cells function as antigen-presenting cells (APCs) capable of regulating T-cell responses in the intestinal mucosa

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Antigen Presentation*
CD4-Positive T-Lymphocytes / immunology
CD8-Positive T-Lymphocytes / immunology
Cell Polarity
Epithelial Cells / cytology
Epithelial Cells / immunology
Histocompatibility Antigens Class II / metabolism
Humans
Intestinal Mucosa / cytology*
Intestinal Mucosa / immunology*
Models, Biological

Substances

Histocompatibility Antigens Class II