Proinflammatory and antitumor properties of interleukin-18 in the gastrointestinal tract

Immunol Lett. 2000 Dec 1;75(1):9-14. doi: 10.1016/s0165-2478(00)00285-6.

Abstract

Interleukin-18 (IL-18) plays a central role in the immune response by acting on Th1 cell differentiation, cell-mediated cytotoxicity and inflammation. The role of IL-18 in cancers and inflammatory diseases is discussed in the light of our investigations on IL-18 synthesis in normal colonic mucosa, colonic cancer and Crohn's disease (CD).

Publication types

  • Review

MeSH terms

  • Colonic Neoplasms / immunology*
  • Colonic Neoplasms / pathology
  • Crohn Disease / immunology*
  • Crohn Disease / pathology
  • Humans
  • Inflammation* / immunology
  • Inflammation* / physiopathology
  • Interleukin-18 / biosynthesis*
  • Interleukin-18 / chemistry
  • Interleukin-18 / physiology*
  • Intestinal Mucosa / immunology*
  • Intestinal Mucosa / metabolism

Substances

  • Interleukin-18