Frequency of protein Z deficiency in patients with ischaemic stroke

Lancet. 2001 Mar 24;357(9260):933-4. doi: 10.1016/S0140-6736(00)04218-5.

Abstract

Prothrombotic phenotype has been described in protein-Z deficient mice, but the thrombotic risk associated with protein Z deficiency in human beings is unknown. We saw a protein Z plasma concentration deficiency of about 20% in 169 patients, from two hospitals, who had ischaemic stroke, whereas the frequency in 88 controls was about 5%. We saw no increase in the frequency of protein Z deficiency in 56 patients with venous thrombophilia. However, why protein Z deficiency was only observed in arterial thrombosis remains unknown.

Publication types

  • Letter
  • Multicenter Study

MeSH terms

  • Adult
  • Blood Proteins / deficiency*
  • Brain Infarction / blood*
  • Case-Control Studies
  • Female
  • Humans
  • Male
  • Venous Thrombosis / blood

Substances

  • Blood Proteins
  • plasma protein Z