Peptide YY secretion in morbidly obese patients before and after vertical banded gastroplasty

Obes Surg. 2002 Jun;12(3):324-7. doi: 10.1381/096089202321088084.

Abstract

Background: The Peptide YY (PYY) secretion pattern was assessed in morbidly obese (MO) patients before and after vertical banded gastroplasty (VBG).

Methods: 12 MO patients (10 women, 2 men) age 29-62 years, BMI 50.7 +/- 9.6 kg/m2, treated with a VBG were studied. Before surgery, blood samples were taken in basal conditions of fasting and 10, 15, 20, 30 and 60 min after the ingestion of a semiliquid test meal. This was repeated in the same patients 6 and 12 months after VBG. Blood samples were also taken from 6 healthy non-obese subjects as controls. PYY plasma concentration was measured by radioimmunoassay with I125.

Results: There were statistically significant differences between the preoperative PYY concentration in MO patients compared to controls. After a VBG, PYY concentration varied significantly compared to the preoperative levels. There was no significant difference between the PYY concentrations in the MO patients after VBG and the controls.

Conclusion: PYY concentration is lower in MO patients compared with non-obese. After VBG, PYY concentration gradually rises to the control levels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Body Mass Index
  • Female
  • Gastroplasty*
  • Humans
  • Male
  • Middle Aged
  • Obesity, Morbid / blood*
  • Obesity, Morbid / physiopathology
  • Obesity, Morbid / surgery*
  • Peptide YY / blood*
  • Peptide YY / metabolism*
  • Postoperative Period
  • Radioimmunoassay
  • Time Factors
  • Weight Loss / physiology

Substances

  • Peptide YY