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16105889,8757311,17660501,17919493,15498035,21227898,17570210,10510366,24252355,11824970,17965065,22108452,12492197,15819704,14993881,15306590,8417116,9521083,9550432,9394814,20440074,12517728,19505427,15880760,15893691,15840100,19086962,17852866,17690575,9973456,15087281,12949719,19444812,17030898,6345034,15238086,16251219,21525383,12838506,18403953,8383717,17900510,16797478,8929454,16766368,16952544,15207783,12153510,15040892,18178611,16099792,12355447,16618789,16451356,11563881,16981178,18360280,19766898,17100768,12494899,8495492,8345182,16293554,14581351,20061410,15522309,18023521,15162447,16102972,21843037,16889669,17368439,19109405,15247173,15331352,24680481,17194481,16083712,17570212,15770395,17996686,15876458,17324400,8912881,11213913,11982596,17032244,12117872,10384110,16510232,21945121,17560924,20166880,10792370,15753533,15183117,17369189,16406844,16674942,17076671,14704635,10570276,16105891,9498757,18024205,17241869,16480433,8563891,10441181,16699371,18188563,16867258,16775121,24125165,9883316,12605119,15671076,21813181,8453675,15810648,22385244,9580314,6425398,15063634,16936808,24060758,15860047,9732937,22760007,14610485,15302846,30778350,19925828,15847059,15086390,11333141,24361466,11464215,11554784,15172447,7769137,12751031,19958311,21946835,11078608,14579144,11511560,8677934,15652945,15128357,25925912,15591503,8021503,15467375,2820630,19080539,12529260,6187670,21928282,11479841,7583927,26216888,15357948,14982519,1512047,20406675,15969670,10445542,15981202,23058476,9038663,1899066,12231473,15762887,26342013,15896666,3159529,9659158,15557426,8409399,10704255,10049518,15968631,14698958,11827101,10775611,10657649,14720442,15492848,9082782,19966577,11788557,7509727,15808880,15590396,22753943,25678452,15770700,7634347,20426926,25000355,15246257,8932856,16023664,16926423,16211344,26529008,19489126,8507887,12442331,15626485,12891535,11781069,15563925,25950701,20230693,23588237,9619371,11279543,15030577,25966995,8548833,28893865,7959194,15151217,15953012,7502812,15622622,15693142,16101938,1319169,8557762,21364874,14726965,20007908,18064301,19708002,20052669,8537046,11922699,15271377,2473955,7606794,30542112,12198691,9867107,12444123,24586509,24229607,11845442,19159826,15282384,14607751,9758721,3920052,6687894,16161453,9510158,15958071,15928580,34861219,12524401,8789893,21506495,30448772,28049849,15016123,15344961,15765404,12727474,15606624,12818278,11531945,15634220,15375608,30923521,14592943,11012771,9659157,10741862,21420224,19996326,8200036,20690180,1829988,11864520,12472679,22777117,11040186,28797042,15654836,15003190,17202336,16048555,26001928,8578684,10219772,23890451,10219845,3105419,12105753,22364936,21288140,15307878,11709515,29884699,9721152,10193412,15637563,22569303,16178891,15289013,15925846,23384903,22705105,16095159,15889264,14981818,33133101,23578511,16234025,16087364,10755257,21938511,20188102,15190609,23690672,12850811,15996156,26297765,8252812,12840152,15194532,10963198,18948814,18435801,26541753,8367483,11341354,24325470,25784526,7615276,11232696,9779965,15749732,15683853,27936497,16060678,10725717,22235998,15182558,22785229,32098623,10447719,3260750,12542829,25447031,18395083,10444257,29559123,17215438,9824341,19805228,18403617,9547996,15884052,17100778,31214623,11531944,15048716,11113073,9250156,11197245,10823523,28654841,19277450,1500733,7429109,26590104,12381533,8453630,9098000,19553528,15541043,1655957,15517613,16002563,12020125,7638572,9434789,17511808,20130691,15916904,1452072,11770044,11982595,23868021,20496807,8244450,8898418,20963699,15885978,30417482,11171837,18821940,1398233,14655147,14617758,2428733,15048152,8809149,11171836,23966426,34257288,15324937,25387079,11986981,17211143,11908704,12229967,15942146,12697412,26309093,11117579,9721154,8982119,10535869,22660791,15357941,15542358,9516640,28174758,7549027,11454791,18512248,12508148,10859218,10989975,21078084,8040334,25902790,20028208,11592072,31622625,17309826,7295059,19735687,28737923,11418660,9508518,15882974,15742460,18258633,12351940,20554485,12792732,22824744,9329125,18540964,8714075,8002034,2947761,29782465,11587736,31123714,27930541,11785680,11380685,23571506,15735428,12851869,10930314,24971453,25590266,16215678,23232296,12827002,12477758,19614867,11985518,26317573,26633478,15925845,10998137,9743616,10601053,21693286,7502814,9203943,27794069,10594681,24238999,15932503,15240735,25948052,21056912,6611297,12008929,26753888,16034145,19821081,23867612,25987506,8669535,14502322,10494405,10582765,12567076,15608660,26304964,10691913,3500240,9834271,26046663,8932779,9530144,23735749,12410804,4685135,27389465,28934294,6606036,9403529,23453631,376409,9846913,11529933,15154017,26742578,34001523,1835480,31505020,19174326,15541040,18472843,22981349,25198673,14987222,9475337,8972749,15976182,20818265,15897920,36219249,25062848,34117105,23998605,29674648,3176334,19250280,30013452,3721290,32165203,27612641,24122227,21109548,8347467,20346253,24358364,19787822,24058482,2935927,9893358,21374439,12914760,12433361,8803609,7342169,15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Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease.

Di Sabatino A, Ciccocioppo R, Cupelli F, Cinque B, Millimaggi D, Clarkson MM, Paulli M, Cifone MG, Corazza GR. Di Sabatino A, et al. Gut. 2006 Apr;55(4):469-77. doi: 10.1136/gut.2005.068684. Epub 2005 Aug 16. Gut. 2006. PMID: 16105889 Free PMC article.

Intraepithelial lymphocytes in human gut have lytic potential and a cytokine profile that suggest T helper 1 and cytotoxic functions.

Lundqvist C, Melgar S, Yeung MM, Hammarström S, Hammarström ML. Lundqvist C, et al. J Immunol. 1996 Sep 1;157(5):1926-34. J Immunol. 1996. PMID: 8757311

Concomitant increase of IL-10 and pro-inflammatory cytokines in intraepithelial lymphocyte subsets in celiac disease.

Forsberg G, Hernell O, Hammarström S, Hammarström ML. Forsberg G, et al. Int Immunol. 2007 Aug;19(8):993-1001. doi: 10.1093/intimm/dxm077. Epub 2007 Jul 28. Int Immunol. 2007. PMID: 17660501

Evidence for the role of interferon-alfa production by dendritic cells in the Th1 response in celiac disease.

Di Sabatino A, Pickard KM, Gordon JN, Salvati V, Mazzarella G, Beattie RM, Vossenkaemper A, Rovedatti L, Leakey NA, Croft NM, Troncone R, Corazza GR, Stagg AJ, Monteleone G, MacDonald TT. Di Sabatino A, et al. Gastroenterology. 2007 Oct;133(4):1175-87. doi: 10.1053/j.gastro.2007.08.018. Epub 2007 Aug 14. Gastroenterology. 2007. PMID: 17919493

Interleukin-12 up-regulates perforin- and Fas-mediated lymphokine-activated killer activity by intestinal intraepithelial lymphocytes.

Ebert EC. Ebert EC. Clin Exp Immunol. 2004 Nov;138(2):259-65. doi: 10.1111/j.1365-2249.2004.02614.x. Clin Exp Immunol. 2004. PMID: 15498035 Free PMC article.

The increased expression of IL-23 in inflammatory bowel disease promotes intraepithelial and lamina propria lymphocyte inflammatory responses and cytotoxicity.

Liu Z, Yadav PK, Xu X, Su J, Chen C, Tang M, Lin H, Yu J, Qian J, Yang PC, Wang X. Liu Z, et al. J Leukoc Biol. 2011 Apr;89(4):597-606. doi: 10.1189/jlb.0810456. Epub 2011 Jan 7. J Leukoc Biol. 2011. PMID: 21227898

CD4+NKG2D+ T cells in Crohn's disease mediate inflammatory and cytotoxic responses through MICA interactions.

Allez M, Tieng V, Nakazawa A, Treton X, Pacault V, Dulphy N, Caillat-Zucman S, Paul P, Gornet JM, Douay C, Ravet S, Tamouza R, Charron D, Lémann M, Mayer L, Toubert A. Allez M, et al. Gastroenterology. 2007 Jun;132(7):2346-58. doi: 10.1053/j.gastro.2007.03.025. Epub 2007 Mar 16. Gastroenterology. 2007. PMID: 17570210

A soluble factor produced by lamina propria mononuclear cells is required for TNF-alpha enhancement of IFN-gamma production by T cells.

Prehn JL, Landers CJ, Targan SR. Prehn JL, et al. J Immunol. 1999 Oct 15;163(8):4277-83. J Immunol. 1999. PMID: 10510366

Dendritic cells promote expansion and survival of aberrant TCR-negative intraepithelial lymphocyte lines from refractory celiac disease type II patients.

Schmitz F, Tjon JM, van Bergen J, Koning F. Schmitz F, et al. Mol Immunol. 2014 Mar;58(1):10-6. doi: 10.1016/j.molimm.2013.10.014. Epub 2013 Nov 16. Mol Immunol. 2014. PMID: 24252355

Effects of dexamethasone on lymphocyte proliferation and cytokine production in rheumatoid arthritis.

De A, Blotta HM, Mamoni RL, Louzada P, Bertolo MB, Foss NT, Moreira AC, Castro M. De A, et al. J Rheumatol. 2002 Jan;29(1):46-51. J Rheumatol. 2002. PMID: 11824970

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