Abstract
Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal inflammation and may open new avenues for development of therapeutic strategies in IBD.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Genetic Predisposition to Disease
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Humans
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Inflammatory Bowel Diseases / genetics*
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Inflammatory Bowel Diseases / immunology
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Inflammatory Bowel Diseases / therapy
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Interleukin-12 / genetics
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Interleukin-23 / genetics*
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Interleukin-23 / immunology
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Mice
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Receptors, Interleukin / genetics
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Receptors, Interleukin / immunology
Substances
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IL23R protein, human
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Interleukin-23
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Receptors, Interleukin
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Interleukin-12