Abstract
NKp46+CD3- natural killer lymphocytes isolated from blood, lymphoid organs, lung, liver and uterus can produce granule-dependent cytotoxicity and interferon-gamma. Here we identify in dermis, gut lamina propria and cryptopatches distinct populations of NKp46+CD3- cells with a diminished capacity to degranulate and produce interferon-gamma. In the gut, expression of the transcription factor RORgammat, which is involved in the development of lymphoid tissue-inducer cells, defined a previously unknown subset of NKp46+CD3- lymphocytes. Unlike RORgammat- lamina propria and dermis natural killer cells, gut RORgammat+NKp46+ cells produced interleukin 22. Our data show that lymphoid tissue-inducer cells and natural killer cells shared unanticipated similarities and emphasize the heterogeneity of NKp46+CD3- cells in innate immunity, lymphoid organization and local tissue repair.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
CD3 Complex / metabolism
-
Cell Division
-
Dermis / immunology*
-
Humans
-
Interferon-gamma / biosynthesis
-
Interleukin-22
-
Interleukins / biosynthesis
-
Intestinal Mucosa / immunology*
-
Lymphocyte Activation / genetics
-
Mice
-
Mice, Inbred C57BL
-
Mice, Mutant Strains
-
Natural Cytotoxicity Triggering Receptor 1 / immunology
-
Natural Killer T-Cells / immunology*
-
Nuclear Receptor Subfamily 1, Group F, Member 3
-
Peyer's Patches / immunology
-
Receptors, Retinoic Acid / genetics
-
Receptors, Retinoic Acid / physiology*
-
Receptors, Thyroid Hormone / genetics
-
Receptors, Thyroid Hormone / physiology*
-
Transcription Factors / genetics
-
Transcription Factors / physiology*
Substances
-
CD3 Complex
-
Interleukins
-
NCR1 protein, human
-
Natural Cytotoxicity Triggering Receptor 1
-
Nuclear Receptor Subfamily 1, Group F, Member 3
-
RORC protein, human
-
Receptors, Retinoic Acid
-
Receptors, Thyroid Hormone
-
Rorc protein, mouse
-
Transcription Factors
-
Interferon-gamma