Marching cohort of Helicobacter pylori infection over two decades (1988-2007): combined effects of secular trend and population migration

Epidemiol Infect. 2011 Apr;139(4):572-80. doi: 10.1017/S095026881000110X. Epub 2010 Jun 7.

Abstract

The prevalence of Helicobacter pylori infection is decreasing in developed countries. In this study we included 22,612 patients in whom a first culture of gastric biopsy (routinely performed in our medical centres) yielded an interpretable result over a 20-year period (1988-2007) in Brussels. The effects of patients' age, gender and ethnic background were analysed. The overall proportion of H. pylori-infected patients was 37·7%, with a progressive decline over time (P<10(-5)). A gender effect was observed in adults. The lowest infection rate was observed in Western European patients (n=11,238) with respectively 36·2% and 15·2% infected subjects in 1988 and 2007, compared to 71·7% and 40% in North African patients (n=3200) (P<10(-5)). However, no trend of decline was observed over time in North African children aged ≤9 years. These data show the effects of time, age and ethnicity on the prevalence of H. pylori infection, and its complex heterogeneity in the same cosmopolitan urban area.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Belgium / epidemiology
  • Biopsy
  • Child
  • Child, Preschool
  • Cohort Studies
  • Emigration and Immigration
  • Ethnicity
  • Female
  • Gastric Mucosa / microbiology
  • Helicobacter Infections / epidemiology*
  • Helicobacter pylori / isolation & purification*
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged
  • Prevalence
  • Risk Factors
  • Young Adult