RT Journal Article
SR Electronic
T1 European consensus conference on faecal microbiota transplantation in clinical practice
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP gutjnl-2016-313017
DO 10.1136/gutjnl-2016-313017
A1 Giovanni Cammarota
A1 Gianluca Ianiro
A1 Herbert Tilg
A1 Mirjana Rajilić-Stojanović
A1 Patrizia Kump
A1 Reetta Satokari
A1 Harry Sokol
A1 Perttu Arkkila
A1 Cristina Pintus
A1 Ailsa Hart
A1 Jonathan Segal
A1 Marina Aloi
A1 Luca Masucci
A1 Antonio Molinaro
A1 Franco Scaldaferri
A1 Giovanni Gasbarrini
A1 Antonio Lopez-Sanroman
A1 Alexander Link
A1 Pieter de Groot
A1 Willem M de Vos
A1 Christoph Högenauer
A1 Peter Malfertheiner
A1 Eero Mattila
A1 Tomica Milosavljević
A1 Max Nieuwdorp
A1 Maurizio Sanguinetti
A1 Magnus Simren
A1 Antonio Gasbarrini
YR 2017
UL http://gut.bmj.com/content/early/2017/01/13/gutjnl-2016-313017.abstract
AB Faecal microbiota transplantation (FMT) is an important therapeutic option for Clostridium difficile infection. Promising findings suggest that FMT may play a role also in the management of other disorders associated with the alteration of gut microbiota. Although the health community is assessing FMT with renewed interest and patients are becoming more aware, there are technical and logistical issues in establishing such a non-standardised treatment into the clinical practice with safety and proper governance. In view of this, an evidence-based recommendation is needed to drive the practical implementation of FMT. In this European Consensus Conference, 28 experts from 10 countries collaborated, in separate working groups and through an evidence-based process, to provide statements on the following key issues: FMT indications; donor selection; preparation of faecal material; clinical management and faecal delivery and basic requirements for implementing an FMT centre. Statements developed by each working group were evaluated and voted by all members, first through an electronic Delphi process, and then in a plenary consensus conference. The recommendations were released according to best available evidence, in order to act as guidance for physicians who plan to implement FMT, aiming at supporting the broad availability of the procedure, discussing other issues relevant to FMT and promoting future clinical research in the area of gut microbiota manipulation. This consensus report strongly recommends the implementation of FMT centres for the treatment of C. difficile infection as well as traces the guidelines of technicality, regulatory, administrative and laboratory requirements.