TY - JOUR T1 - Several aspects in study design need further consideration JF - Gut JO - Gut DO - 10.1136/gutjnl-2017-315692 SP - gutjnl-2017-315692 AU - Cheng-Bei Zhou AU - Jing-Yuan Fang Y1 - 2018/01/12 UR - http://gut.bmj.com/content/early/2018/01/11/gutjnl-2017-315692.abstract N2 - We read with interest the work by Cheung et al1 describing that patients with prior Helicobacter pylori eradication therapy receiving long-term proton pump inhibitors (PPIs) therapy are still at enhanced risk of gastric cancer development, particularly for non-cardia cancer. As the current consensus report stated, long-term treatment with PPIs in H. pylori-positive patients accelerates the process of loss of specialised glands, leading to atrophic gastritis. Hence, it is recommended that eradication of H. pylori heals gastritis in patients … ER -