TY - JOUR T1 - Surveillance of premalignant gastric lesions: a multicentre prospective cohort study from low incidence regions JF - Gut JO - Gut DO - 10.1136/gutjnl-2017-314498 SP - gutjnl-2017-314498 AU - Wouter J den Hollander AU - I Lisanne Holster AU - Caroline M den Hoed AU - Lisette G Capelle AU - Tjon J Tang AU - Marie-Paule Anten AU - Ingrid Prytz-Berset AU - Ellen M Witteman AU - Frank ter Borg AU - Gijsbert den Hartog AU - Marco J Bruno AU - Maikel Petrus Peppelenbosch AU - Wilco Lesterhuis AU - Michael Doukas AU - Ernst J Kuipers AU - Manon C W Spaander Y1 - 2018/06/06 UR - http://gut.bmj.com/content/early/2018/06/06/gutjnl-2017-314498.abstract N2 - Objective International guidelines recommend endoscopic surveillance of premalignant gastric lesions. However, the diagnostic yield and preventive effect require further study. We therefore aimed to assess the incidence of neoplastic progression and to assess the ability of various tests to identify patients most at risk for progression.Design Patients from the Netherlands and Norway with a previous diagnosis of atrophic gastritis (AG), intestinal metaplasia (IM) or dysplasia were offered endoscopic surveillance. All histological specimens were assessed according to the updated Sydney classification and the operative link on gastric intestinal metaplasia (OLGIM) system. In addition, we measured serum pepsinogens (PG) and gastrin-17.Results 279 (mean age 57.9 years, SD 11.4, male/female 137/142) patients were included and underwent at least one surveillance endoscopy during follow-up. The mean follow-up time was 57 months (SD 36). Four subjects (1.4%) were diagnosed with high-grade adenoma/dysplasia or invasive neoplasia (ie, gastric cancer) during follow-up. Two of these patients were successfully treated with endoscopic submucosal dissection, while the other two underwent a total gastrectomy. Compared with patients with extended AG/IM (PGI/II≤3 and/or OGLIM stage III–IV), patients with limited AG/IM (PG I/II>3 and OLGIM stage 0–II) did not develop high-grade adenoma/dysplasia or invasive neoplasia during follow-up (p=0.02).Conclusion In a low gastric cancer incidence area, a surveillance programme can detect gastric cancer at an early curable stage with an overall risk of neoplastic progression of 0.3% per year. Use of serological markers in endoscopic surveillance programmes may improve risk stratification. ER -