Faecal SCFA concentrations before and during treatment (μmol/g wet weight)
| Baseline | Active | Difference | 95% CI | p Value | ||||
| Acetic acid7-150 | ||||||||
| Wheat bran | 72.9 | (41.5) | 81.0 | (25.7) | 8.1 | −14.8 to 31.1 | 0.460 | |
| Senna | 63.9 | (32.5) | 138.2 | (56.4) | 74.3 | 37.1 to 111.5 | >0.001 | |
| Loperamide | 79.8 | (39.2) | 51.6 | (31.6) | -28.2 | −57.5 to 1.1 | 0.057 | |
| Propionic acid† | ||||||||
| Wheat bran | 24.0 | (14.2 to 34.7) | 21.9 | (14.6 to 28.7) | 3.4 | −14.4 to 4.9 | 0.890 | |
| Senna | 18.4 | (13.6 to 29.9) | 40.3 | (22.5 to 59.8) | 18.6 | 4.6 to 33.1 | 0.025 | |
| Loperamide | 27.2 | (18.9 to 37.3) | 16.6 | (9.3 to 30.4) | -4.3 | −16.1 to −1.1 | 0.018 | |
| Butyric acid† | ||||||||
| Wheat bran | 69.0 | (21.8 to 128.6) | 79.4 | (32.8 to 102.3) | 0.0 | −35.4 to 27.6 | 1.000 | |
| Senna | 16.6 | (5.0 to 24.2) | 59.1 | (29.2 to 82.4) | 38.9 | 15.5 to 65.0 | 0.006 | |
| Loperamide | 24.8 | (17.9 to 45.9) | 6.0 | (0.0 to 37.0) | -11.8 | −23.3 to −0.8 | 0.032 | |
| Total SCFA† | ||||||||
| Wheat bran | 95.0 | (64.5 to 167.5) | 113.0 | (90.5 to 149.5) | 11.8 | −24.0 to 34.5 | 0.750 | |
| Senna | 111.0 | (72.5 to 161.0) | 202.0 | (162.0 to 226.5) | 76.0 | 26.5 to 120.5 | 0.005 | |
| Loperamide | 152.0 | (86.0 to 197.0) | 82.0 | (65.0 to 130.0) | -28.0 | −101.0 to −1.5 | 0.045 | |
↵7-150 Results expressed as mean (SD); †expressed as median (interquartile range).