Cholesterol and bile acid metabolism in control subjects and patients with an ileoanal anastomosis
| Parameter | Controls (n=15) | Patients without pouchitis history (n=18) | Patients with pouchitis history (n=6) |
| Cholesterol (mg/kg/day) | |||
| Absorption (%) | 47.0 (1.6) | 36.0 (2.3)** | 36.0 (2.7)** |
| Faecal elimination as neutral steroids | |||
| Dietary | 2.6 (0.2) | 2.9 (0.1) | 2.8 (0.2) |
| Endogenous | 6.9 (1.0) | 5.3 (0.6) | 5.5 (1.0) |
| Total | 9.8 (0.8) | 8.2 (0.6) | 8.3 (1.2) |
| Intestinal influx | |||
| Dietary | 4.8 (0.4) | 4.6 (0.2) | 4.5 (0.4) |
| Endogenous | 13.0 (1.8) | 8.2 (0.8)5-150 | 8.7 (1.8) |
| Total | 17.9 (1.7) | 12.8 (0.9)5-150 | 13.2 (2.2) |
| Absorption | |||
| Dietary | 2.3 (0.3) | 1.7 (0.1) | 1.6 (0.2) |
| Endogenous | 6.1 (0.9) | 3.1 (0.4)** | 3.2 (0.9)5-150 |
| Total | 8.5 (0.9) | 4.6 (0.5)*** | 4.8 (1.0)5-150 |
| Synthesis | 10.3 (1.2) | 12.2 (1.4) | 15.9 (2.2)5-150 |
| Bile acids (mg/kg/day) | |||
| Faecal elimination | 5.7 (0.4) | 9.6 (1.3)** | 12.0 (1.8)** |
| Biliary output | 121.4 (16.3) | 58.0 (8.4)** | 81.5 (29.8) |
| Reabsorption (%) | 94.1 (0.9) | 81.6 (2.7)*** | 77.4 (4.8)** |
Results expressed as mean (SEM).
↵5-150 p < 0.05, **p < 0.01, ***p < 0.001 versus control values.