Table 2

Plasma concentrations of gastrointestinal hormones (in pg/ml) before and after administration of sumatriptan in seven healthy volunteers

Variable Control Sumatriptan p Value
Median motilin concentration309 (38)317 (42)NS
Peak motilin concentration393 (46)403 (49)NS
Median motilin concentration during MMC cycle326 (42)316 (44)NS
Motilin concentration associated with phase 3376 (32)* 213 (23)0.009
Median somatostatin concentration7.5 (0.9)5.6 (0.9)0.005
Median somatostatin concentration during MMC cycle6.8 (2.2)5.3 (1.7)0.04
  • Results are expressed as median (SEM). Median hormone concentrations before and after sumatriptan were calculated from respectively 14.3 (1.4) and 11.1 (1.0) samples per subject. The median hormone concentrations during the MMC cycle before and after sumatriptan were calculated from respectively 7.1 (0.8) and 6.4 (1.8) samples per subject. *Significantly different from the motilin level during the MMC cycle before sumatriptan.